Greg Falls, Phd, Dabt

Greg Falls, Phd, Dabt Email and Phone Number

Senior Director, Toxicology at SpringWorks Therapeutics @ SpringWorks Therapeutics
Greg Falls, Phd, Dabt's Location
Raleigh-Durham-Chapel Hill Area, United States, United States
Greg Falls, Phd, Dabt's Contact Details

Greg Falls, Phd, Dabt personal email

n/a

Greg Falls, Phd, Dabt phone numbers

About Greg Falls, Phd, Dabt

Greg Falls, Phd, Dabt is a Senior Director, Toxicology at SpringWorks Therapeutics at SpringWorks Therapeutics. He possess expertise in toxicology, drug development, drug discovery, biomarkers, in vivo and 45 more skills.

Greg Falls, Phd, Dabt's Current Company Details
SpringWorks Therapeutics

Springworks Therapeutics

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Senior Director, Toxicology at SpringWorks Therapeutics
Greg Falls, Phd, Dabt Work Experience Details
  • Springworks Therapeutics
    Senior Director, Toxicology
    Springworks Therapeutics Apr 2022 - Present
    Stamford, Connecticut, Us
    SpringWorks Therapeutics is a clinical-stage biopharmaceutical company that identifies and advances promising science and pioneers efficient pathways for drug development for patients with severe rare diseases and cancer.
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  • Precision Biosciences, Inc.
    Senior Director, Head Of Translational Drug Development
    Precision Biosciences, Inc. Oct 2019 - Apr 2022
    Durham, North Carolina, Us
    Lead a team of development Program Leaders (PLs) and nonclinical scientists; Oversee and/or conduct studies in transgenic models and MTD, PK, biodistribution, and toxicity studies in NHPs.Partner with Business Development, external collaborators, and serve on Joint Steering Committees.Ex vivo gene-editing program support including allogeneic CAR-T led to 4 successful IND filings in a little over 3 years.In vivo gene-editing program support with AAV and LNP transgene delivery in transgenic models and NHPs.Responsible for nonclinical safety sections of regulatory documents including briefing books (e.g., INTERACT, preIND) and filings (e.g., IND).IND-enabling efficacy, PK, biodistribution, and GLP safety studies.Nonclinical program representation supporting liver, skeletal muscle, or ocular targets in addition to nondisclosed targets.
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  • Precision Biosciences, Inc.
    Director, Head Of Immunotoxicology
    Precision Biosciences, Inc. Aug 2018 - Oct 2019
    Durham, North Carolina, Us
    Nonclinical Lead for allogeneic CAR T programs conducting IND-enabling tumor model efficacy and GvHD studies.Qualify and oversee research and GLP CROs for program-specific studies.
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  • Rai Services Company
    Senior Toxicologist, Scientific And Regulatory Affairs
    Rai Services Company Dec 2015 - Aug 2018
    Nonclinical and Regulatory support for Niconovum in the development of combination drug/medical devices and Kentucky Bioprocessing in vaccine development.
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  • Glaxosmithkline
    Manager, Investigative Tox & Path
    Glaxosmithkline Jun 2003 - 2015
    Brentford, Middlesex, Gb
    Safety Assessment Project Leader for Anti-Viral, Endocrine, and Metabolic Disease ProgramsDesigned and managed preclinical safety assessment (i.e., toxicology, metabolism, and toxicokinetic), pharmacology (i.e., primary and secondary activities), and genotoxicity studies to support progression for lead optimization, candidate selection, and IND filings. • Conducted target organ toxicity studies in animal models• Developed novel in vitro and in vivo screening tools for cardiotoxicity and hepatotoxicity• Designed gene silencing (siRNA), cKO, and whole body KO studies to elucidate mechanisms of skeletal- and cardio-myopathy, and hepatotoxicity Discovery and Molecular Toxicologist/Principal InvestigatorDesigned investigative studies to predict and/or address toxicity; method development;Laser-capture microdissection; Affymetrix Genechip® arrays, Illumina microarrays; TaqMan analysis (CardioTaq, HepatoTaq); microRNA analysis (tissue and circulating); and bioinformatic/pathway analysis (Ingenuity, ArrayStudio) for toxicogenomic studies• Key contributor in global public-private partnerships (Health Environmental Sciences Institute, C-Path Preclinical Safety Testing Consortium) and academic collaborations (Harvard Stem Cell Institute, Duke University, NCSU Veterinary School)• Developed a TaqMan Low Density Array (TLDA), CardioTaq, to identify predictive biomarkers; CardioTaq implemented to reduce compound attrition. • Scientific expertise in toxicogenomics, cardiotoxicity, and hepatotoxicitySA Representative for Corporate Due Diligence Teams• Prepared scientific documentation for full due diligence reviews for joint venture and/or acquisition evaluation covering diverse drug targets (diabetes, depression, hepatitis, muscle-wasting) and technologies (aptamers, organ-on-a-chip)Early Safety Prediction Toxicologist• Authored numerous reports to address potential toxic liabilities for new drug targets (lit. review, corporate intelligence, and bioinformatics).
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  • Bristol-Myers Squibb
    Senior Research Investigator
    Bristol-Myers Squibb Sep 2001 - Jan 2003
    Lawrence Township, Nj, Us
    Bristol-Myers Squibb PRI, Preclinical Candidate Optimization, Discovery Toxicology (Wilmington, DE)Senior Research Investigator in Discovery ToxicologyProject Leader/Study Director• Programs included obesity and metabolic diseases• Proposed and conducted mechanistic studies to support discovery (e.g., in vitro/in vivo studies for parietal cell necrosis, phospholipidosis) and development programs including hepatic gene expression studies and mechanistic studies for thyroid toxicity Principal Investigator • Built and managed molecular biology and toxicogenomics lab which utilized Affymetrix Genechip® arrays, real-time PCR, data analysis software, etc.; initiated collaboration with Gene Logic• Directed/performed metabonomic and microarray studies for the Consortium on Metabonomic Toxicology (COMET) and the International Life Sciences Institute (ILSI), respectively
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  • Dupont
    Senior Research Scientist
    Dupont 1999 - 2001
    Wilmington, De, Us
    DuPont Pharmaceuticals Company, Safety Assessment (Newark, DE)Senior Research Scientist in Discovery ToxicologyProject Team Leader• Safety Assessment representative for the selective estrogen receptor modulator(SERM) project team• Designed and conducted over 40 preclinical safety and mechanistic studies to support IND regulatory filings• Prepared documents including Technical Basis of Nomination, Candidate Development Plan, and Clinical Investigator’s BrochureStudy Director/Monitor• Designed and directed preclinical safety studies of discovery/development compounds (anti-viral, anti-inflammatory, anti-cancer, central nervous system, and cardiovascular agents)• Responsible for data analysis/interpretation, reporting of study results (GLP and non-GLP studies)• Directed technical staff; monitored studies performed by contract research organizations
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  • Duke University
    Post-Doctoral Fellow
    Duke University 1996 - 1999
    Durham, North Carolina, Us
    Duke University Medical Center, Dept. of Rad. Oncology (Durham, NC) 1996-1999Postdoctoral Research FellowMolecular Genetics and Carcinogenesis• Investigated genomic imprinting in cancer, mechanisms of IGF2R loss in Wilms’ Tumor• Developed screen for novel imprinted genes, identified potential cancer genes• Performed in vivo tumorigenesis studies, in vitro studies• Transgenic models for IGF2R functionality (Cre-loxP knockout)
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  • Icf International
    Scientist
    Icf International May 1990 - May 1991
    Reston, Virginia, Us
    Environmental auditing/consulting; formerly known as K.S. Crump Division of Clement International Corporation
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Greg Falls, Phd, Dabt Skills

Toxicology Drug Development Drug Discovery Biomarkers In Vivo Life Sciences Glp In Vitro Pharmacology Pharmaceutical Industry Molecular Biology Clinical Development Ind Pharmacokinetics Adme Cro Biotechnology Cell Animal Models Oncology Immunology Drug Metabolism Dmpk Cell Biology Assay Development Biopharmaceuticals Lifesciences Biochemistry Regulatory Submissions Translational Medicine Pharmacodynamics Cell Culture Bioanalysis Vaccines Lead Change Pharmaceuticals Pharmaceutical Development Product Development Hplc Lc Ms Medicinal Chemistry Clinical Trials Infectious Diseases Regulatory Affairs Genomics Pharmaceutics Cancer Real Time Polymerase Chain Reaction Bioinformatics Clinical Research

Greg Falls, Phd, Dabt Education Details

  • North Carolina State University
    North Carolina State University
    Toxicology
  • University Of Louisiana Monroe
    University Of Louisiana Monroe
    Toxicology

Frequently Asked Questions about Greg Falls, Phd, Dabt

What company does Greg Falls, Phd, Dabt work for?

Greg Falls, Phd, Dabt works for Springworks Therapeutics

What is Greg Falls, Phd, Dabt's role at the current company?

Greg Falls, Phd, Dabt's current role is Senior Director, Toxicology at SpringWorks Therapeutics.

What is Greg Falls, Phd, Dabt's email address?

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What schools did Greg Falls, Phd, Dabt attend?

Greg Falls, Phd, Dabt attended North Carolina State University, University Of Louisiana Monroe.

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What skills is Greg Falls, Phd, Dabt known for?

Greg Falls, Phd, Dabt has skills like Toxicology, Drug Development, Drug Discovery, Biomarkers, In Vivo, Life Sciences, Glp, In Vitro, Pharmacology, Pharmaceutical Industry, Molecular Biology, Clinical Development.

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