Gregory Miles Email & Phone Number

Santa Clara, Ca, Us

- Manage two bioinformatics teams focused on clinical services projects, developing NGS pipelines, and supporting the Genomics Informatics software portfolio.- Collaborate with Scientists, R&D, marketing, QA, support, and upper management on new initiatives, including the development of clinical sequencing tests and informatics software improvements.- Design and conduct clinical NGS analyses to enhance the identification and classification of genetic variants, including: whole genome/exome (SNV/CNV/SV calling), Single-Cell, RNA-Seq, and Methyl-Seq using open-source tools, statistical analysis, and R/Python scripting/pipeline development.- Develop, implement, and validate scalable analysis pipelines for clinical targeted NGS products.- Provide leadership, guidance, and cross-functional technical expertise across teams.- Develop/lead Agilent VIP program to support high-volume customers.- Identify/resolve critical software issues affecting clinical analysis results, leading to improvements in software R&D/Quality, cost savings, and increased customer satisfaction.- Provide secondary/tertiary bioinformatics expertise and automated solutions to customers and internal stakeholders to support Agilent’s end-to-end (fastq to report) clinical NGS workflow solution.

- Co-developed a microRNA-based liquid biopsy cancer screening diagnostic platform for breast cancer, despite an unsuccessful outcome.- Led strategic planning, including resource allocation, timeline management, and budget oversight.- Developed regulatory planning and reimbursement strategy to ensure requirement compliance.- Formed clinical academic partnerships with two top-tier institutions for preclinical/pilot studies.- Led investor outreach, networking initiatives, experimental execution, and bioinformatics work.

Munich, De

-Analyzed microRNA-sequencing data from patients with Dilated Cardiomyopathy (DCM) patients.-Developed bioinformatics sequencing analysis pipelines towards integrated predictive models for DCM.-Provided variant calling and RNA-Seq expertise to Corporate Technology Research team members.-Conducted statistical analysis of open-source microRNA-seq alignment and read quantification tools by correlating patient samples from cardiovascular disease sequencing and “gold-standard” qRT-PCR experimental platforms using generalized linear models and machine learning.

New Brunswick, Nj, Us

-Led collaborative oncology research teams – biologists, core facilities, clinicians, and bioinformaticians within the Rutgers Cancer Institute of New Jersey (CINJ) network, including Johnson & Johnson, Princeton University, and Rutgers – including grants and journal publications based on analysis of large-scale data from NGS and gene-expression microarray platforms. -Managed functional genomics/NGS programs and provided expert-level bioinformatics research support, including: statistical analysis of NGS and microarray data, machine learning, software and database engineering, QC, data visualization, pathway/network analysis, and genome-wide association (GWAS), as part of a successful NCI Comprehensive Cancer Center designation status renewal, including an “Outstanding” rating for the Cancer Bioinformatics CORE.-Developed an algorithm for prospectively identifying ovarian cancer patients destined to fail standard first-line therapies implemented in a new lab-developed test in the initial stages of a clinical trial.-Led, published and presented key translational research identifying microRNA/mRNA deregulations in ovarian cancer and glioblastoma using a novel algorithm at IBSB2010 in Tokyo, Japan.-Led award-winning collaboration identifying molecular signatures in childhood AML to attain funds (R01 grant) for large scale RNA-Seq profiling study.-Hosted RNA-Seq/Variant calling workshop at 2014 NGS for Cancer Drug Development conference.

Woking, Surrey, Gb

-Provided on-site training to BioBook users within Roche and Wyeth pharmaceuticals.

Hillsborough, Nj, Us

-Developed/tested/debugged DeltaSoft’s ChemCart bioinformatics software (Java, Oracle) package.

Boston, Ma, Us

-Led gene expression microarray time-course analysis research study exploring the response of male mice to feminized patterns of growth hormone.-Provided bioinformatics analysis and expertise for a gene expression microarray study designed to locate sex-specific genes regulated by STAT5A and HNF4α in mice, resulting in two publications.-Performed wet-lab rotation exploring restriction endonuclease and methyl transferase biology under the direction of 1993 Nobel Laureate Dr. Rich Roberts at New England Biolabs.-Presented weekly progress reports at lab meetings and completed all Ph.D-related requirements.

Bethesda, Md, Us

-Designed multiple sclerosis biomarker curation database with TOAD/MYSQL and Java/JSP interface.

Binghamton, Ny, Us

Ph.D, Bioinformatics And Systems Biology

M.S, Bioinformatics And Systems Biology

B.S., Computer Science

B.S., Biological Sciences

High School Diploma