Amy Griffiths Email & Phone Number

Burlington, Vermont

At Green Mountain Antibodies, I oversee our product line of monoclonal antibodies to blood coagulation proteins.

In the laboratory of Dr. Philip Fay, I was involved in projects examining the role of coagulation Factor VIII and its various partners, including thrombin, Factor IXa, and Factor X. I utilized mammalian and insect expression systems and a site-directed mutagenesis approach to determine specific intra- and inter-molecular interactions of Factor VIII through surface plasmon resonance, mass spectrometry, and kinetic approaches. Collaboration with team members as well as independent project work lead to a number of publications, and presentation at an American Society of Hematology meeting. I also served as laboratory manager, responsible for maintenance of the lab, training of staff, and safety.

While at Penn State, I conducted an independent research project to assess the role of iron-sulfur clusters in various proteins, utilizing techniques including cloning, mutagenesis, expression in E. coli, anaerobic protein purification, and characterization with a focus on spectroscopy. In addition, I instructed undergraduate laboratories in Elementary Biochemistry and Protein Purification and Enzymology.

Master'S Degree, Biochemistry

Bachelor'S Degree, Chemistry

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