Scientific and Operational Manager (PhD, MSc) with more than 35 years of experience in the Biotech/Biopharmaceutical industry.Guy has been involved in several domains of the biomanufacturing process: from the Molecular Biology, diverse expression systems (mainly mammalian/CHO cells but also microbial, yeasts, recombinant vaccinia viruses, transgenic animals and plants), USP/production using SUB/SSB up to 2,000-L scale, DSP/purification (affinity capture development, chromatographic steps, viral inactivation, nanofiltration, formulation development, etc.), Fill&Finish, QC (IPC, IPT, batch release, stability studies, HCP removal and testing, viral clearance study), up to the GLP/GMP validation and preparation of the dossiers for regulatory agencies (EMA, FDA)Mainly by leading operational interactions with external CROs/CMOs, Dr de Martynoff has worked at every development step of the biomanufacturing process for 10+ pharmaceutical candidates, from the feasibility studies up to the clinical batch production (BDS, DP). Guy has also accumulated expertise in the (pre)clinical environment as study monitor (dedicated ELISA, in vitro biopotency testing, PK, PD, biodistribution/tumor models, ADA, etc.).During his professional pathway, he has been directly involved in the development of more than 180 recombinant proteins: viral proteins for diagnostic or vaccines (HCV, HPV), cytokines/immunocytokines, clotting factors, antibodies (full-length and bispecific IgG, nanobodies, radio-immunoconjugates, ADC).