www.haikalab.com HaikaLab / Translational Immunology Research Program (TRIMM) & iCAN Digital Precision Cancer Medicine Flagship

The Jänne Lab, DFCI/Harvard Medical SchoolI'm developing new targeted therapy strategies to prevent and reverse EGFR inhibitor resistance in lung cancer. This includes therapeutic strategies to directly degrade the EGFR receptor by using the ubiquitin-proteasome pathway, as well as studying new ways to vertically or in parallel block the EGFR survival signaling by using combination strategies. The research utilizes cutting-edge research models, such as 3D-culture platforms and patient-derived xenograft (PDX) models.Technical expertise:- 3D culture methods- Flow cytometry, cell sorting - High-throughput drug screening- Proximity-ligation assays- Confocal microscopy, imaging- Protein assays- Immunology, immuno-oncology- Proteosomal degradation, PROTACs- CRISPR gene editing- Small molecules- Antibody-drug conjugates- In vivo work- Oncology- Data analysis

The Jänne Lab, DFCI/Harvard Medical School

Market feasibility studies, project management, business model analysis, networking, strategy and business planning.

In my thesis work I explored how to use oncogene-induced cell death sensitivity for more effective cancer treatments. Since I worked in close collaboration with both clinicians and pharmaceutical companies, different areas of drug development and translational research became familiar to me during my projects. Alongside research, I have worked as a freelance employee for a startup management company and gained experience in the biotech industry.Technical expertise:- Apoptosis assays- 3D culture, patient samples- In vivo models: PDX, GEMMs- Confocal microscopy- CRISPR gene editing - Immuno-oncology, immunoprofiling- Histochemistry, protein assays- Lentiviral work- Metabolic assays- ChipSeq