Hannah Perrin Email & Phone Number

Morrisville, Nc, Us

Remote

Remote

• Performed variant interpretation according to standard operating procedures using a combination of manual and automated processes focusing on pediatric, ocular, and metabolic diseases and carrier testing • Evaluated scientific literature for clinical and functional evidence to interpret the significance of genetic variation and provided succinct summaries• Trained on gene curation to describe associations between genes and diseases• Skilled with resources to interpret and classify the significance of genetic variation including Alamut, IGV, HGMD, NCBI, gnomAD, ClinVar, and OMIM

Chapel Hill, Nc

Defended February 2022. Generated and analyzed next generation sequencing data for chromatin accessibility and gene expression using a variety of bioinformatic tools. My project identified regulatory mechanisms that contribute to complex human diseases particularly relating to cardiovascular and metabolic traits.Integrative Vascular Biology Training Grant, 3 years Teaching Experience:Guest Lecturer - “Web Based Genetic and Genomic Resources”. 2019.Teaching Assistant - "Quantitative Genetics", "Human Genetics and Genomics", and "Mouse Model Genetics". 2018.North Carolina DNA Day - “DNA Repair”, “Forensics”, and “Personalized Medicine”. 2017, 2018, 2019.Selected Presentations:“Context-dependent chromatin accessibility and gene expression during adipocyte differentiation identifies regulatory mechanisms at cardiometabolic trait GWAS loci” American Society of Human Genetics Poster, Virtual. 2020.“Chromatin accessibility during adipocyte differentiation identifies regulatory elements at cardiometabolic trait GWAS loci” Talk at Integrative Vascular Biology Symposium, UNC. 2019.Papers:“Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci”. PLOS Genetics. 2021. PMID: 34699533.“Genetic effects on liver chromatin accessibility identify disease regulatory variants”. American Journal of Human Genetics. 2021. PMID: 34038741.“Identification of type 2 diabetes loci in 433,540 East Asian individuals”. Nature. 2020. PMID: 32499647.“Adiponectin loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences”. PLOS Genetics. 2020. PMID: 32915782.“Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits”. G3: Genes, Genomics, Genetics. 2019.

Gaithersburg, Md

-Front line supervisor in a high volume CLIA certified lab responsible for lab workflow including PCR, PCR product visualization, PCR product rearrangement, and Sanger sequencing-Directly supervised 5-7 DNA Technicians with responsibilities including training, skill development, competency assessments, and performance evaluations-Assisted in implementation and enforcement of QAQC policies to comply with CAP and CLIA certification-Awarded Special Team Recognition for assistance in implementation of an automated magnetic bead cleanup process which improved sequencing success by ~10%-Awarded for Excellence for producing the highest quantity of successful manual PCR while performing on and leading multiple teams-Workflow improvement projects included: (1) transition of equipment used to stamp plates which saved ~$250 per stock bottle aliquoted, ~$4000 over the following year, (2) upgraded and validated 3730 sequencers and Biomeks to new software versions, and (3) validation of new reagents to produce cleaner product visualization images-Developed, maintained, and enforced Standard Operating Procedures-Developed and implemented appropriate solutions to problems encountered on a daily basis-Developed Excel tools to organize and simplify laboratory tasks including a Master Mix calculator for ~30 validated protocols and a template to plan flexible QIAgility robotic PCR runs-Presented continuing education topics concerning workflow and skill development-Coordinated weekly shift schedules for all department teams-Provided tours of the sequencing lab and overviews of all processes-Researched literature and guides to troubleshoot problems and plan validations-Managed routine maintenance and advanced troubleshooting of a variety of lab equipment Equipment: 3730xl sequencer, Hamilton Micro Lab Star, Biomek NX, Agilent Bravo, QIAxcel, QIAgility, Flash Gel

Patuxent River Naval Base, Patuxent River Md

-Granted four Segal AmeriCorps Education Awards for terms of service in association with The Student Conservation Association-Surveyed bird populations for a variety of species and environments to promote conservation-Helped with additional environmental surveys including mammals, amphibians, insects, and invasive-exotic species surveys-Prepared bird study skins-Collected deer tissue samples for genetic studies of deer populations-Guided tours of a small Natural History Museum-Provided care for a variety of live animals for educational purposes including spiders, turtles, fish, and venomous snakes

St. Mary'S City, Md

-Supervised & trained employees at the St. Mary’s College Library-Implemented changes to improve the accuracy & efficiency of shelving at the library-Assisted patrons in locating research materials

Doctor Of Philosophy (Phd), Genetics, Certificate In Bioinformatics And Computational Biology

Defended February 2022. I generate and analyze next generation sequencing data for chromatin accessibility and gene expression. My project.

Master Of Science (Ms), Biotechnology, Concentration: Bioinformatics, 3.9

Relevant Coursework: Biostatistics, Bioinformatics: Tools for Genome Analysis, and Advanced Practical Computer Concepts for Bioinformatics.

Ba, Biochemistry, Biology, English, Environmental Studies

Obtained a BA in Biochemistry, Biology, and English and a minor in Environmental Studies.