AREAS OF RESPONSIBILITYEnsuring that ERAs of LEO Pharma pharmaceuticals are complying with authorities' requirement worldwide; EMA, FDA, FASS, etc. Management of GLP and OECD studies at CROs.Ensuring that API manufacturing effluents are minimized and comply with authority guidelines and limits. Performing desktop and on-site audits of CDMOs and suppliers of APIs and raw materials. Focus: Sustainability and compliance with environmental law and the work… Show more AREAS OF RESPONSIBILITYEnsuring that ERAs of LEO Pharma pharmaceuticals are complying with authorities' requirement worldwide; EMA, FDA, FASS, etc. Management of GLP and OECD studies at CROs.Ensuring that API manufacturing effluents are minimized and comply with authority guidelines and limits. Performing desktop and on-site audits of CDMOs and suppliers of APIs and raw materials. Focus: Sustainability and compliance with environmental law and the work environment.Investigating the circular economy aspects of the production. Supporting colleagues in the dialogue with the Danish authorities about environmental license to operate.Supporting colleagues in compliance with REACH, CLP and GHS, including safety data sheets, as well as transport of dangerous goods on road and by air.Representing LEO Pharma in the EFPIA PIE Task Force. Show less

AREAS OF RESPONSIBILITYEnsure that environmental risk assessments of LEO Pharma pharmaceuticals are in accordance with current legislation, worldwide, as well as supporting colleagues in the dialogue with the Danish authorities about environmental licence to operate.Supporting colleagues in compliance with REACH, CLP and GHS, including safety data sheets, as well as transport of dangerous goods on road and by air.Performing desktop evaluation and on-site inspection of… Show more AREAS OF RESPONSIBILITYEnsure that environmental risk assessments of LEO Pharma pharmaceuticals are in accordance with current legislation, worldwide, as well as supporting colleagues in the dialogue with the Danish authorities about environmental licence to operate.Supporting colleagues in compliance with REACH, CLP and GHS, including safety data sheets, as well as transport of dangerous goods on road and by air.Performing desktop evaluation and on-site inspection of suppliers of APIs and raw materials with respect to compliance with environmental law and the work environment.Representing LEO Pharma in the EFPIA Pharmaceuticals in the Environment Task Force. Show less

Censor on BSc and MSc projects within environmental chemistry.

Representing LEO Pharma in this inter association (EFPIA, MfE and AESGP) task force on Pharmaceuticals in the Environment (PIE).

o As the only pharmacist at work I am as such the responsible at the pharmacyo The amount of customers varies depending on the day, but especially depending on the time of day. All shifts have their stressed time periods and I am therefore used to working in a high-paste environment – also with answering phone calls from doctors and customers with questions and concerns of various types o The main issues at the shifts are of course treatment of acutely occurred pains… Show more o As the only pharmacist at work I am as such the responsible at the pharmacyo The amount of customers varies depending on the day, but especially depending on the time of day. All shifts have their stressed time periods and I am therefore used to working in a high-paste environment – also with answering phone calls from doctors and customers with questions and concerns of various types o The main issues at the shifts are of course treatment of acutely occurred pains, infections, coughing and colds, wounds and bruises, but besides that, customers also come to pick up medicine for their chronic diseaseso I have therefore maintained and broadened my knowledge of drugs on the Danish market, despite the natural focus on pain, infections etc on the shiftso It is a prerequisite for me that the customer is sufficiently informed in order to use the medicine and to be in compliance with the treatmento I am an experienced user of Pharmanet Show less

RESEARCHAs a senior researcher at DTU Environment I gained a broad and deep experience within urban pollution. During a number of years I worked with 1) mapping the pollution pressure from urbane releases, 2) characterising the sources to pollution in the urban space, 3) potential recycling of urban water, 4) options for reducing urban releases, and 5) designed measuring campaigns using traditional and passive sampling.Latest I compiled and analysed ecotox data from nine… Show more RESEARCHAs a senior researcher at DTU Environment I gained a broad and deep experience within urban pollution. During a number of years I worked with 1) mapping the pollution pressure from urbane releases, 2) characterising the sources to pollution in the urban space, 3) potential recycling of urban water, 4) options for reducing urban releases, and 5) designed measuring campaigns using traditional and passive sampling.Latest I compiled and analysed ecotox data from nine nanomaterials published in hundreds of scientific articles, aiming at deriving safe environmental levels. To assess the reliability of the data, an approach with specific emphasis on evaluation of ecotox data for nanomaterials for regular purposes was developed.During the majority of my university career I have been engaged in environmental risk assessment of chemicals, e.g. pharmaceuticals, nanomaterials as well as traditional pollutants.I also regularly performed peer review of scientific articles and have been member of about 10 PhD thesis assessment committees.TEACHING AND DISSEMINATION On top of my research I have supervised students (through PhD level) in formulating a project, performing experiments, analysing and interpreting data and writing the thesis. Using various didactic methods, my teaching of graduate students focused on environmental and human health risk assessment of chemicals as well as applied environmental analytical chemistry and water pollution. As an integral part of my work I am experienced in presenting results and conclusions at at more than 15 international conferences and have published more than 25 papers in peer reviewed scientific journals, including writing rebuttal letters. Show less

Worked with Prof Peter Vanrollegem on the fate of micropollutants in stormwater and stormwater treatments ponds within the EU funded project ScorePP coordinated by Prof Peter Steen Mikkelsen (DTU ENV)

As a pharmacist at a medium sized pharmacy in Elsinore my primary task was to handle customers, including information about and guidance in the use of medicals. Furthermore I was responsible for the internal information and education.

I studied the in vivo expression of mRNA of peptide transporters 1 and 2 in the rat under the influence of epidermal growth factor. Tissue samples were collected and RNA extracted. The extracted RNA was amplified and quantified using polymerase chain reaction and gel electrophoresis, respectively.

I used HPLC-UV to quantify parent compound and to obtain purity profiles of tablets under stability testing. LC-MS-MS was used to elucidate the structure of degradation products. The experiments were conducted in order to develop a method to predict the stability of drug compounds in tablets on a long-term basis, by studying the influence of oxygen pressure, temperature and humidity as a function of time.Publication: Holten Lützhøft HC, Foged C, Rasmussen SR, Lehmann S, Olsen H. 2004. J… Show more I used HPLC-UV to quantify parent compound and to obtain purity profiles of tablets under stability testing. LC-MS-MS was used to elucidate the structure of degradation products. The experiments were conducted in order to develop a method to predict the stability of drug compounds in tablets on a long-term basis, by studying the influence of oxygen pressure, temperature and humidity as a function of time.Publication: Holten Lützhøft HC, Foged C, Rasmussen SR, Lehmann S, Olsen H. 2004. J Pharm Sci, 93, 1142-1153. Show less

In the EU 5th Framework Programme project “Environmental Risk Assessment of Veterinary Medicines in Slurry (ERAVMIS)” I worked on developing analytical methods to quantify antimicrobials present in slurry, soil, groundwater and surface water using SPE and LC-UV/fluorescence and LC-MS-MS. I also acted as a co-supervisor of a PhD student. The work resulted in two publications: Blackwell PA, Lützhøft HCH, Ma HP, Halling-Sorensen B, Boxall A, Kay P. 2004. J Chromatogr A, 1045, 111-117 and… Show more In the EU 5th Framework Programme project “Environmental Risk Assessment of Veterinary Medicines in Slurry (ERAVMIS)” I worked on developing analytical methods to quantify antimicrobials present in slurry, soil, groundwater and surface water using SPE and LC-UV/fluorescence and LC-MS-MS. I also acted as a co-supervisor of a PhD student. The work resulted in two publications: Blackwell PA, Lützhøft HCH, Ma HP, Halling-Sorensen B, Boxall A, Kay P. 2004. J Chromatogr A, 1045, 111-117 and Blackwell PA, Lützhøft HCH, Ma HP, Halling-Sorensen B, Boxall ABA, Kay P. 2004. Talanta, 64, 1058-1064. Show less

Supervisors: Prof Bent Halling-Sørensen and Prof emeritus Sven Erik Jørgensen.Antimicrobials are applied in fish farming to treat and prevent infections among the farmed fish.Investigations have shown that antimicrobials can be found in the environment as a possible result of antimicrobial treatment in fish farms.When antimicrobials are discharged to the evnrionment various processes take place. Biotic and abiotic degradability is often low. Despite their low… Show more Supervisors: Prof Bent Halling-Sørensen and Prof emeritus Sven Erik Jørgensen.Antimicrobials are applied in fish farming to treat and prevent infections among the farmed fish.Investigations have shown that antimicrobials can be found in the environment as a possible result of antimicrobial treatment in fish farms.When antimicrobials are discharged to the evnrionment various processes take place. Biotic and abiotic degradability is often low. Despite their low hydrophobicity some antimicrobials interact with Aldrich humic acids, thus lowering their free concentrations and enhancing their persistence. Laboratory experiments have shown that antimicrobials in low concentrations inhibit the growth of algae; especially cyanobacteria.Based upon specified exposure scenarios most antimicrobials would upon request require more detailed investigations.The study resulted in the Ph.D. thesis: Environmental Risk Assessment of Antimicrobials (ISBN 87-988069-0-4). Show less

Stayed at Dr JLM Hermens’ laboratory at Institute of Risk Assessment Sciences (formerly: RITOX: Research Institute of Toxicology). Worked with development of nd-SPME-HPLC methods to quantify free concentrations of 4-quinolones in aqueous samples containing humic acids to establish pH-dependent distribution coefficients between humic acids and water for three 4-quinolones.Publication: Holten Lützhøft HC, Vaes WHJ, Freidig AP, Halling-Sørensen B, Hermens JLM. 2000. Environ Sci… Show more Stayed at Dr JLM Hermens’ laboratory at Institute of Risk Assessment Sciences (formerly: RITOX: Research Institute of Toxicology). Worked with development of nd-SPME-HPLC methods to quantify free concentrations of 4-quinolones in aqueous samples containing humic acids to establish pH-dependent distribution coefficients between humic acids and water for three 4-quinolones.Publication: Holten Lützhøft HC, Vaes WHJ, Freidig AP, Halling-Sørensen B, Hermens JLM. 2000. Environ Sci Technol, 34, 4989-4994.Additionally the pH-dependent 1-octanol/water distribution coefficients for oxolinic acid were established applying HPLC-UV analysis.Publication: Publikation: Holten Lützhøft HC, Vaes WHJ, Freidig AP, Halling-Sørensen B, Hermens JLM. 2000. Chemosphere, 40, 711-714. Show less