Preclinical and Translational Pharmacokinetics / Pharmacodynamics subject matter expert and project team representative driving novel biopharmaceutical drug candidates (antibodies, ADCs, gene therapies) to the clinic

My investment philosophy: Invest in amazing teams and get out of their way. I’m not arrogant enough to think I can do your job better than you!

• Providing biotechnology industry insight into scientific, regulatory, and strategic risk for investment decisions• Performed scientific due diligence on a biotech with clinical and pre-clinical drug candidates for a Chicago- and NYC-based boutique investment bank

Pharmacokinetics (PK) Sciences, Translational Medicine, NIBR• Served as bioanalytical scientific expert on project teams for pre-clinical low molecular weight drug candidate programs• Conducted bioanalytical assays support for preclinical drug development in GLP/GCP research lab and served as Expert Scientific Monitor for outsourced PK and TK studies• Provided ADME and bioanalytical subject matter expertise to project teams in for pipeline programs from preclinical through phase III clinical trials• Evaluation of novel technologies in LC-MS and near-patient testing in translational medicine• Served on cross-functional workstreams for digital development, communications, and outsourcing strategy

Laboratory of Ben O'Shaughnessy, Department of Chemical Engineeringwith dual appointment as Laboratory Associate at Yale University (Tom Pollard and Erdem Karatekin Labs) Modeling actomyosin and cell membrane mechanics in cell division• Mathematical modeling and simulation• Identified unique role of multiple myosin motor isoforms in cytokinesis force generation • Developed novel applications of confocal microscopy and micropipette manipulation for measuring sub cellular force and dynamics• Liaised as collaboration lead among three laboratories in diverse fields (cell biology, biophysics, theoretical biology) across Columbia and Yale Universities

Laboratory of Frederick R. Maxfield, Department of BiochemistryFluorescence microscopy and biochemistry of immunological cell mechanisms of atherosclerosis• Established role of Toll-like Receptor (TLR4)-dependent Akt/PI3K cell signaling pathways in macrophage cytoskeletal response to pro-atherosclerotic cholesterol-rich particles using inhibitor treatments, knockout cell lines, and siRNA knockdown• In vitro biochemical and cell based assays for macrophage foam cell signaling• High-throughput automated confocal microscopy-based cellular assay and workflow for quantitative readout of subcellular actin levels and trafficking in primary macrophages and cell lines• Mammalian tissue culture work (J774 macrophages, HEK293) and transfection in primary bone-marrow derived hematopoietic cell cultures

Dissertation research in the laboratory of Enrique M. De La Cruz, Department of Molecular Biophysics & BiochemistryKinetics and enzymology of molecular motors (actin, myosin) and GTPases in cell trafficking• Kinetic and thermodynamic analysis • Biochemistry and molecular biology• Protein purification and biochemical characterization • Co-developer of a novel myosin V-specific pharmacological inhibitor• Cell culture, Sf9/baculovirus expression system