Human antibody engineering and the use of human antibodies in discovery research and in the treatment of emergent infectious diseases.

Using HIV-I platform for vaccine development against infectious diseases such as H1N1, H5N1, HIV, and Hepatitis C. Developing gene therapy approaches against HIV.

Human genetics: investigation of the genetic etiology of congenital diaphragmatic hernia (CDH) in humans using 100K SNP chip. Zayed et al. Am J Med Genet A. 2010 Apr;152A(4):916-23.A maternally inherited chromosome 18q22.1 deletion in a male with late-presenting diaphragmatic hernia and microphthalmia-evaluation of DSEL as a candidate gene for the diaphragmatic defect.Department of Pediatrics, Division of Genetics, University of California, San Francisco, California 94143-0748, USA.

Human gene therapyZayed et al. Mol Ther. 2007 Jul;15(7):1273-9. Epub 2007 Apr 24.Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery.Zayed et. al. Hum Gene Ther. 2006 Feb;17(2):158-66.In vitro functional correction of the mutation responsible for murine severe combined immune deficiency by small fragment homologous replacement.