Heiko Blaser, Phd, Mba Email & Phone Number

Toronto, Ontario, Canada

Medical Leadership and Responsible Therapeutic Areas: HAE, Immunology, Rare Hematology, Rare Genetics/Metabolic, Transplant/CMV, and AATD1. Leadership, Coaching & Management:Leading and Coaching a team of (6), Associate Medical Directors, Medical Advisors and Medical Science Liaisons to develop and execute the Medical Strategy in Rare Diseases at Takeda Canada that resulted in numerous successful product launches2. Strategic Planning and Tactical Execution:-> 6+ years of experience in Medical Affairs covering and/or leading the medical activities in therapeutic areas such as Post-Transplant Infectious Disease Management, Rare Bleeding Disorders, Rare Lysosomal Storage Diseases, Oncology, Hereditary Angioedema, Primary and Secondary Immunodeficiencies and Alpha-1 Antitrypsin Deficiency-> Leading the Medical Strategy that supported the Regulatory and Access process to successfully launch various products within the Takeda portfolio (e.g. LIVTENCITY, GLASSIA, HYQVIA, VONVENDI, ALUNBRIG, NINLARO). Life-cycle management of products such as TAKZHYRO, ADYNOVATE, OBIZUR, REPLAGAL, and VPRIV3. Communication and Presentation:25+ years of experience in communicating scientific information to medical experts and communities at international conferences, health regulatory body in Canada, health technology assessment entities, public and private payers, and patient organizations that led to access of various innovative medicines for Canadian patients

Toronto, Ontario, Canada

Toronto, Canada Area

Medical Lead of Rare Hematology for Takeda Canada Inc. in Canada.

Ontario, Canada

+ Leading the development and implementation of the Strategic Brand Plan and local customer initiatives in line with the Brand Strategy to maximize brand performance.+ Drives market and competitor research – application of central segmentation in local context and competitive insights.+ Directing generation and analysis of data to seek out opportunities including life cycle management to support recommendations for strategic direction based on demand and market dynamics.+ Partnering with the Oncology KAM team/ Sales force to provide strategic direction in the development of training material and programs; ensure coherence of key messages and gather customer insights. Partners with key internal departments (Sales, Marketing, Medical, PSP, HR, IT, Regulatory, Supply Chain, Takeda International) by taking a leadership role in the communication and liaison between all departments at Takeda.+ Leading and taking ownership for key financial tasks for the brand including the development of annual budgets, operating plan, market sales forecasts, quarterly updates, etc.+ Develops and maintains strong external team relationships (Agency, Specialists and their associations, Advisory groups, PAAB) by taking a leadership role in the communication and liaison between all pertinent external customers.

Oakville, Canada

I was responsible for covering the provinces of Ontario, Manitoba and Newfoundland in Canada acting as a Medical/Science Liaison between Takeda's Medical Affairs Team and healthcare professionals who improve patients lives.Disease focus: malignant hematology, specifically Multiple MyelomaFor more information, please refer to my attached resume.

Toronto, Canada Area

Team leader of 5 direct reports: cancer research on the discovery of novel therapeutics targets.• Manage a team of scientists (direct reports) and lead the design/development of projects with the goal of identifying novel potential therapeutic avenues in Oncology.• Control and manage project scope and budget to meet deadlines in a timely manner.• Employ scientific/medical knowledge that I acquired in the field of Oncology in 6+ years to consult with clinicians, experts in drug-development and bioinformatics to discuss putative novel therapeutic targets and their clinical relevance on patient prognosis.• Work with a cross-functional team to file patent applications in the US that incorporate novel discoveries found by my research team.• Collaborate with industry partners to develop tools that my team applies for cancer research.• Established professional collaborations with oncologists and pathologists to conduct research studies based on clinical/medical data.• Present and discuss research findings at meetings with internal and external experts in the field of Oncology and Drug Development/Discovery.• In-depth analysis of putative new therapeutic targets using cancer microarray datasets with clinical annotation such as cbioportal, oncomine and PrognoScan.• Study the role of novel genes in tumorigenesis and metastasis in vivo using human cancer xenograft models.

The Campbell Family Institute For Breast Cancer Research, Toronto, Canada Area

Cancer Research Scientist: Lead researcher on the discovery of novel genes involved in cancer development/progression.• Collaborated with pathologists at Toronto General Hospital using a human breast cancer tissue array to correlate specific protein expression levels to tumor grade and subtype.• Presented research findings at international conferences and discussed potential future therapeutic directions with peer-scientists, clinicians and industry experts.• Published research data in peer-reviewed scientific/medical journals and wrote grant applications that secured funding for multi-stage research projects.• Utilized a cDNA ORF library comprised of 4000 transmembrane proteins to screen for genes that promote tumor growth in lungs and lymph-nodes.• Developed/engineered new cancer cell lines from primary mouse mammary tumor tissues that were used for drug target discovery.• Studied the inhibition of cancer cell derived lung metastasis by gene-specific knockdowns of 100+ different kinases and cytoskeletal regulators.• Studied the molecular mechanisms important for cancer cell migration, invasion, proliferation and survival/cell death.

Muenster, Germany

Molecular Biologist: Led research on the discovery of molecular mechanisms involved in primordial germ cell (PGC) chemotaxis, migration and invasion downstream of CXCL12/CXCR4 signaling.• Prepared/edited/published original research findings in high impact peer-reviewed journals and organized funding.• Presented research findings at international conferences (poster presentations) that led to scientific collaborations.• Invited Speaker on the 9th DGZ Young Scientists Meeting on “Signaling cascades in Development and Disease”. Muenster, Germany.

Goettingen, Germany

Molecular Biologist: Led research on the discovery of molecular mechanisms involved in primordial germ cell (PGC) chemotaxis. • Prepared/edited/published original research findings in high impact peer-reviewed journals and organized funding from the Roche Research Foundation.• Presented research findings at international conferences (oral and poster presentations).• Discovered novel PGC specific markers and developed transgenic animals to trace PGC development and chemotaxis in a living organism by live confocal microscopy.• Studied the involvement of E-cadherin, myosin, MLCK, the Rho-GTPase family, calcium and GPCR (CXCL12-CXCR4) signaling in the process of PGC chemotaxis and polarization in vivo.

Zurich, Switzerland

Worked in the lab of Dr. Igor Stagljar.• Exploited the Yeast-2-Hybrid system (Y2H) to study novel protein-protein interactions of the Bloom-helicase (BLM) important for DNA mismatch repair.• Performed yeast (Saccharomyces cerevisiae) tetrad dissection for molecular genetics to produce strains with new genetic combinations or mutations.• Prepared technical documentation such as experimental outlines, reports, laboratory protocols, and analytical method SOPs.

Winterthur Area, Switzerland

Biochemical Engineer candidate: Collaborative R&D work for a pharmaceutical company.• Collaborated with Lonza Ltd to improve the bio-transformation process for the production of (S)-piperazine-2-carboxylic acid, which is used for the synthesis of the HIV protease inhibitor Crixivan.• Established/implemented scale-up bacteria cultures (Klebsiella terrigena) in 20L bioreactors in the department of Chemical and Biochemical Engineering.• Applied innovative scientific methods and used them to optimize the bio-catalytic procedure to increase yield and improve quality of the chemical end product.

Zürich Area, Switzerland

In-bound and out-bound transportation/delivery logistics of international airfreight for costumer-airlines such as: Swiss, Lufthansa, Singapore Airlines, American Airlines, United, British Airways, Air France, KML, Continental Airlines, DHL, etc.Business areas – Contract Logistics, Freight Logistics, Port Logistics and Public Transport

Basel Area, Switzerland

Lab technician: Pre-clinical R&D on small molecule inhibitors against HIV.• Worked on a team of senior scientists to pilot plant scale up the production/manufacturing of pharmaceutical drugs in the therapy area of acquired immunodeficiency syndrome.• Produced accurate scientific data in compliance with company policies, ensured that Pharma Rx Reporting guidelines, SOP and GMP were implemented and followed.• Reported daily progress and results to project manager on routine matters to achieve projects goals/scope and meet deadlines.

Master Of Business Administration (Mba), Business Administration And Management, General

Phd, Molecular Biology, Summa Cum Laude

Doctorate - Doctor of Philosophy - Ph.D. - Molecular Biology - Georg-August- Universität Göttingen - Completed Thesis Title: Molecular.

Bachelor'S - Bsc. In Chemistry, Molecular Biology And Analytical Chemistry

Bachelor's - BSc. in Chemistry - Molecular Biology and Analytical Chemistry - Maastricht University - Completed Thesis Title: Survey.

Bachelor'S - Bsc. In Chemistry, Organic Chemistry

Bachelor's - BSc. in Chemistry - Chemistry, Biotechnology - Zurich University of Applied Sciences (ZHAW) - Completed Thesis Title.

Apprenticeship, Lab-Chemist/Technician, Chemistry

Ciba/Novartis Work Description: Apprenticeship as a technician in Chemistry done in CIBA (Novartis). Research in Chemistry, anti-HIV small.