Our research is focused on the mechanisms of cellular dynamics, cross-talk and networks, including the characterization of specific cell membrane-material interactions, to identify new targets that will guide the engineering of translational nanotechnology-based systems for drug delivery, imaging and immunotherapy in specific clinically relevant situations (cancer, inflammation, genetic diseases). Novel formulation procedures are currently being adapted to microfluidic technics to support the continuous control of those methodologies aiming at translational nanomedicines. I am focused on the development of multivalent nanotechnology-based systems to modulate the recognition, capture, processing and presentation of cancer antigens by dendritic cells. It includes the in vitro and in vivo studies of the anti-tumor effects induced by the combination of these nanovaccines with nanotherapeutics designed to modulate the function and activation of other key cells within tumor site, such as T cells, myeloid-derived cells and tumor cells.