• Aided efficient advancement of drug candidates from discovery to clinical trial execution by collaborating with the discovery and development functions to provide strategic biological, biomarker and clinical guidance• Contribute to authorship of non-clinical pharmacology study reports, invention disclosures, sections of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents• Developed, established and managed collaborations with key external researchers including academic and industry partnerships to support the Syros’ product development strategy via external research• Designed, managed, analyzed, interpreted, and reported studies aimed at informing pharmacodynamic biomarkers, predictive biomarkers, and mechanisms of action for drugs in various phases of development

• Designed, managed, analyzed, interpreted, and reported pharmacology studies to facilitate the proof-of-concept of novel ideas and translation to the clinic.• Presented study plans and results to team and senior management.• Work collaboratively with project teams• Proposed new research ideas• Identified and selected CROs to conduct in vitro and in vivo pharmacology studies.• Engaged with KOLs, interact with external collaborators and managed CROs

I led a team of scientists responsible for discovery and development of drug candidates and providing support to existing programs. My role involved direct contribution to the scientific research as an individual contributor and as a management leader.Select Results:• Led programs developing new therapies from the initial project planning through preclinical studies• Nurtured and developed a team via mentoring, training and hiring • Evaluated new research opportunities, oversaw experiments aimed to identify new drug candidates and support IND packages • Mentored research scientists in laboratory practices, including study design, protocol generation, data analyses and report writing• Developed assays for drug candidate characterization • Contributed new ideas and proof-of-concept studies to enable the initiation of new projects• Supported development of intellectual property • Communicated results across the company (departmental, executive and board of director meetings)• Prepared and monitored departmental budget Served on program teams for projects currently in clinic• Engaged with KOLs and interact with external collaborators• Coordinated timing, priority and personnel for individual studies • Established milestones to meet company goal -- proposed departmental and individual goals which aligned with company goals & oversaw performance reviews• Collaborated closely with chemistry, ADME, clinical and project management teams• Contributed to patent applications, investigator brochures, and clinical protocols• Promoted from Senior Scientist I to Senior Scientist II in 2011• Promoted from Senior Scientist II to Senior Scientist III in 2015• Promoted from Senior Scientist III to Associate Director in 2016• Served as biological safety officer, safety committee chair, and IACUC member

- wrote research proposals that were awarded funding by National Institute of Health- designed, executed and analyzed experiments which characterized role of Notch signaling and chromatin remodeling during avian retinal regeneration- worked as part of collaborative team that investigated retinal neuron regeneration in mouse models- supervised rotation graduate students- presented and actively participated in Developmental Neurobiology Journal Club- presented results as a poster at Northwest Developmental Biology Conference- prepared manuscripts for publication- technical skills used include but not limited to: immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation, microscopy (Nomarski, epiflourscence, confocal), cell transfection, reporter gene analysis, quantitative RT/PCR, SDS/PAGE, Western blotting. immortalized and primary cell culture, in vivo experience with chickens and mice, intraocular injections, retinal dissections