Responsible for developing a portfolio of projects targeting nuclear receptors and designing numerous high content phenotypic screens to identify novel chemical matter. Contributed to redesigning the internal Hit to Lead process. Also have a significant responsibility on a high priority effort to improve external innovation by investigating local academic labs, biotech companies, and venture capital firms to identify technologies or other assets of interest to Sanofi.

I lead the Molecular Genomics Section with responsibilities including supervision and development of ~22 people performing high throughput sequencing, cloning, automation and transcript profiling. For these activities I was appointed as co-lead of an integration team during Sanofi-Aventis merger and subsequently as a global scientific coordinator across 5 sites and 3 countries. Developed novel approach for SAR assays using multiplexed transcriptional readouts and applied successfully to a… Show more I lead the Molecular Genomics Section with responsibilities including supervision and development of ~22 people performing high throughput sequencing, cloning, automation and transcript profiling. For these activities I was appointed as co-lead of an integration team during Sanofi-Aventis merger and subsequently as a global scientific coordinator across 5 sites and 3 countries. Developed novel approach for SAR assays using multiplexed transcriptional readouts and applied successfully to a variety of compound optimization projects. Global project lead for a compound 'deorphaning' project - successfully identified mechanism of action and primary protein target for a novel oncology compound using a wide variety of molecular approaches and data mining. Significant experience in the management of complex, international projects, networking in a large matrix organization, managing budgets, and mentoring of PhD level scientists. Show less

Responsibilities included membership on the management team for the genomics center (~65 people), development of all Laboratory Informatics and Automation applications including data analysis and visualization pipelines. Collaborated with Drug Safety Department in implementing Toxicogenomics approaches to the preclinical evaluation of compounds. Project lead for the creation of a compound reference database based on Affymetrix profiles that was applied to numerous compound mechanism of action… Show more Responsibilities included membership on the management team for the genomics center (~65 people), development of all Laboratory Informatics and Automation applications including data analysis and visualization pipelines. Collaborated with Drug Safety Department in implementing Toxicogenomics approaches to the preclinical evaluation of compounds. Project lead for the creation of a compound reference database based on Affymetrix profiles that was applied to numerous compound mechanism of action studies including compounds targeting kinases and the classification of hits from phenotypic screens. Experience in managing large scale systems development, building and leading project teams, portfolio management and target discovery. Show less

Responsible for laboratory informatics and automation technology development in a cutting edge molecular biology department. Supervised three MS level research associates. Worked on the design of Laboratory Information Management Systems (LIMS) for sequencing workflow, clone management and transcriptional profiling that incorporate both computer and handheld (PDA) device interfaces. Helped implement significant components of the technology transfer agreement between Aventis and Millennium.

Responsible for process automation at CuraGen. Automated high throughput PCR reactions, dye primer and dye terminator sequencing chemistry, and developed numerous custom liquid handling applications using a variety of platforms. Suggested and implemented numerous improvements for key company process including sequencing and quantitative expression analysis.

NIDDKLaboratory of Chemical Physics