Hye In Kim Email & Phone Number

New York, New York, US

New York, New York, US

Integrative Biology team within Internal Medicine Research Unit

Tarrytown, New York, US

• Advisors: Cris Van Hout, PhD & Alan Shuldiner, MD
• Characterized the exome architecture of a founder population and performed ExWAS to find candidate genes and variants that are associated with metabolic disorders [Published at AJHG, Reviewer's choice abstract at ASHG.
• Developed and implemented a novel bioinformatic and statistical pipeline for genome-wide screen of parent-of-origin specific effects on EHR-derived clinical traits in DiscovEHR and UKBB studies [Published at HGG.
• Performed statistical genetics modeling in diverse populations including UKBB, DiscovEHR, and founder populations with focus on cardiometabolic traits.
• Provided human genetics evidence for the evaluation of an existing target.
• Designed and performed functional experiments using in vitro and in vivo models in collaboration with therapeutic focus area groups to validate the phenotypic impacts of a candidate gene identified from ExWAS.

Philadelphia, PA, US

• Thesis: Interrogating the molecular mechanisms of genetic association at the SLC22A1 locusAdvisor: Dan Rader, MD
• Dissected independent genetic association signals at a metabolite QTL by conditional analysis and haplotype association test.
• Prioritized coding variants in strong LD with GWAS sentinel variants as candidate causal variants and demonstrated their functional impacts on protein function in vitro.
• Identified a putative splice variant with allele-specific expression in human liver RNA-seq data and validated its effect on splicing by CRISPR knock-in in cells.
• Demonstrated a novel function of the candidate effector gene using metabolomics and functional genomics approaches in cell and mouse models.
• Employed Mendelian randomization method to test the causal effect of serum metabolites on T2D.

Phd Candidate, Cell And Molecular Biology / Genetics

Bachelor Of Science (B.S.), Biology