Chris Holmes Email & Phone Number

Indiana, United States

Engaged to help businesses develop and refine their growth strategy while leading the enablement of that strategy through capital project delivery and operational handover. Focused in the pharmaceutical industry with a specialization in biologics, including cell and gene therapy.

Bloomington, Indiana, United States

Led global engineering efforts in business unit consisting of six sites in U.S. and EU; sites included analytical services, sterile fill finish (vials, syringe, cartridges, lyophilization), and drug substance manufacturing (MAB, mRNA, LNP, etc.). Identified strategic capital investments needed to support planned strategic growth of Biologics business and provided support to business case development and option evaluation during project gating process. Developed leadership capabilities and ensured succession plans for key leadership positions while serving as a coach and mentor to junior leaders. • Oversaw scope development, estimating, and scheduling commitments as part of building capital project proposals and administered and oversaw master site planning efforts at sites as required. Ensured planning and delivery of capital investments to meet business goals.• Drove site projects and project teams as needed, worked with sites to problem solve and clear roadblocks during execution, and coordinated project governance for sites in network.• Supported operating sites in capital planning, technical reviews on projects, and review, analysis, and recommendations on new technologies and / or service providers.

Baltimore, Maryland Area

Held responsibility for overall strategy and operations for facilities, engineering, EHS, security, and capital projects for all sites in Paragon Gene Therapy business unit of Catalent, supporting multi-stage product development and clinical and commercial manufacturing. Created organizational design and recruited and managed teams (over 70 EE) supporting existing, fully operational properties as well as those in stages of construction and commissioning; teams included maintenance and utilities, metrology, engineering (process, automation, and utility), EHS, security, and capital project execution.• Executed design, startup, and commissioning of new, 210,000-sq.-ft. commercial facility in Baltimore, Maryland.• Held responsibility for over 720,000 sq. ft. of leased and owned space to support cell and gene therapy company.• Worked to secure space and design over 500,000 sq. ft. of space for cell and gene therapy manufacturing.• Developed and oversaw facilities budget ($300M), including staffing, rent, capital projects, utilities, and maintenance.

Rockville, Md

Held responsibility for design, construction, and commissioning of new commercial manufacturing facility. Supervised and directed all of MacroGenics’ operations (Maryland and California) under facilities and engineering function. Oversaw all building capital projects, including design and construction / commissioning / startup of commercial antibody manufacturing facility ($45M) and related management of contractors; managed metrology service to support GMP, GLP, GCP, and business needs. Designed organizational strategy / structure to meet growing needs and execute new steps of the development. • Developed and maintained strategic space plan to manage real estate, including team of 15 employees that handled day-to-day services to keep all buildings running efficiently.• Negotiated and oversaw all facility service agreements company wide.• Ensured compliance with all leasing and permitting requirements and acted as primary business point of contact for landlords, real estate agents, and permitting / zoning agencies.• Developed and managed facilities budget ($10M), including rent, capital projects, utilities, and maintenance.

Performed all aspects of facilities management for USP’s U.S. operations, including preventive / corrective maintenance for all building systems / infrastructure, site security and access control, housekeeping, reception, receiving dock, mail delivery, copying services, managing service agreements, space planning, and lease management. Oversaw operations for multiple buildings and locations containing manufacturing, R&D, and biologic labs, distribution and warehousing operations, large conference center, and office space. Managed staff of 23, annual operating budget in excess of $10M, and annual capital budget of ~$3M.• Managed A&E and general contractors to design and build various site improvements (totally revised distribution operation that was constructed while it continued to operate and meet all operational targets).• Drove cost savings in excess of $1M annually by implementing multifaceted, comprehensive environmental sustainability strategy; development and implementation of strategy received funding from PEPCO and State of Maryland for $800,000, driving project payback to less than two years.

Frederick, Md

Managed all aspects of facilities, engineering, and Environmental, Health and Safety (EHS) for multi-building biotech operation, including cGMP manufacturing, laboratory, multiple large data centers, large distribution hub, chemical and biological labs (both R&D and production), antibody manufacturing, and animal management.• Moved manufacturing and R&D of 150-employee antibody manufacturing operation from California to Maryland, moved oligonucleotide manufacturing operation of 50 employees from Maryland to California, and moved primary / stem cell manufacturing operations from Oregon and North Carolina to Maryland.• Managed team of 10 employees and budgets in excess of $4M annually.

Led all initiatives regarding corporate environmental sustainability; role required strategic development, communication, influencing others to achieve objectives, technical knowledge, and budget management. Focused on eco-efficiency measures and associated cost savings, greenhouse gas management, creating green culture, and regulatory compliance. • Managed corporate climate change strategy. • Supported submittals to maintain listing on Dow Jones Sustainability Index, FTSE4Good financial index, and Maplecroft Climate Innovation Index. • Developed corporate EHS standards and audited sites internationally and throughout U.S. for compliance with these standards.

Managed all EHS aspects for eight Invitrogen operations located primarily in eastern half of North America (Texas, Wisconsin, New York, Connecticut, Maryland, North Carolina, Ontario) and ran global EHS projects, including part of corporate sustainability initiative.• Established corporate EHS Excellence Awards program to identify and acknowledge achievements in EHS for all global operations. • Traveled domestically and internationally to perform audits and manage EHS initiatives.

Bloomington, Indiana, United States

Managed all aspects of EHS for 800-employee contract cGMP pharmaceutical manufacturing operation, which included managing implementation of EHS management systems, industrial hygiene and control banding, and occupational health / nursing and fitness center. Reported to director of engineering and managed staff of six and annual budget more than $1M. • Led site to ISO 14001 certification. • Managed EHS risks, including exposure to active pharmaceutical ingredients, in cGMP environment. • Participated in construction of award-winning parenteral pharmaceutical manufacturing operation (formulation, filling, finishing, and lyophilization).

Bachelor Of Science (B.S.), Environmental Science

Master Of Business Administration (M.B.A.), Business Administration And Management, General