Jenny Holt Email & Phone Number

San Francisco, California, Us

San Francisco, California, Us

Emeryville, California, Us

Management of gene therapy product development across multiple functional areas. Leading a team of 10 Project Managers and development of PMO.

Emeryville, California, Us

Management of AAV Gene Therapy program in retina. Includes management of the internal retina program as well as alliances with partners. Experience in product development, program management, regulatory, and rare disease.Management of AAV Gene Therapy program pushing development from R&D through clinical. Hands-on and cross-functional experience including Alliance Management, Program Management, Preclinical In-Vivo Studies, Clinical Operations, Clinical Science, and Regulatory. Program manager of two programs into the clinic in Ophthalmology space.

Co-Founder and advisor. Program management, translational, regulatory.

Basel, Baselstadt, Ch

Cancer Biology Department focused on development of new and novel small molecule cancer drugs based on genetics of cancer cells.Core Team member of resistance group- developing models to study and anticipate cancer resistance to small molecular inhibitors.Study of Cell Cycle and DNA Damage and Repair.

Us

• Molecular Biology – restriction digests, ligations, generation of plasmid preps.• PCR, ELISA, Western blots, Southern Blots.• Cell culture and virology.• Transfection and generation of purified adenovirus.• Bioselection: random mutagenesis of Ad5 virus to develop enhanced potency in cancer cells.

South San Francisco, Ca, Us

• Generated Onyx-proprietary virus through mutagenesis and selection.• Molecular biology techniques: PCR, site-directed mutagenesis, generation of new restriction sites, insertion and deletion of genes, screening and amplification of new plasmids for transfection into live virus.• Sequence confirmation of virus.• Large scale prep and purification.• Cytopathic effect evaluation of newly generated virus.• Valued team member who trained new employees.

San Francisco, California, Us

Investigated use of gene therapy in atherosclerotic arteries.• Managed and maintained the Core Sequencing Facility.• Ran automated sequence and oligonucleotide synthesizer.• Provided consultation and training in sequencing to colleagues.• Efficiency gained through streamlining core facility provided time for professional development in gene therapy lab.• Developed cloning skills and generation and purification of adenovirus.• Experience with animal work including tagging mice and assisting in surgery on rabbits.