Hope Burks Email & Phone Number

Chicago, Illinois, United States

Tissue Models team co-leadDeveloping engineered skin models and instrumented tissues to monitor and characterize inflammatory processes on a molecular level.

Chicago, Il

Principle Investigator: Kathleen Green-Utilized 3 dimensional epidermal equivalent cultures, transcriptomics and patient tissue staining to identify and characterize a bidirectional paracrine signaling module between keratinocytes and melanoma cells in the epidermal tumor niche responsible for initiation of melanoma intra-epidermal spread.-Analyzed transcriptomics data from 3 rare and understudied acantholytic skin disorders: Darier Disease, Hailey-Hailey Disease and Grover's… Show more Principle Investigator: Kathleen Green-Utilized 3 dimensional epidermal equivalent cultures, transcriptomics and patient tissue staining to identify and characterize a bidirectional paracrine signaling module between keratinocytes and melanoma cells in the epidermal tumor niche responsible for initiation of melanoma intra-epidermal spread.-Analyzed transcriptomics data from 3 rare and understudied acantholytic skin disorders: Darier Disease, Hailey-Hailey Disease and Grover's disease to identify mechanisms of disease manifestation and identify potential therapeutic targets using pathway analysis through GSEA and IPA as well as comparisons with characterized inflammatory signatures in keratinocytes. Show less

New Orleans, La

Principal Investigator: Matthew Burow-Studied the role of HDAC1 and HDAC2 in TNBC progression and metastasis

Principle Investigator: Matthew Burow- Characterized the role of ZEB1 and ZEB2 in a non-canonical, epithelial to mesenchymal transition independent model of breast cancer metastasis and drug sensitivity in an estrogen receptor positive, Luminal A breast cancer system. -Developed a series of triple negative patient derived xenograft models. -Engaged in collaborations exploring interactions between breast cancer cells and adipocyte derived stem cells, as well as developing… Show more Principle Investigator: Matthew Burow- Characterized the role of ZEB1 and ZEB2 in a non-canonical, epithelial to mesenchymal transition independent model of breast cancer metastasis and drug sensitivity in an estrogen receptor positive, Luminal A breast cancer system. -Developed a series of triple negative patient derived xenograft models. -Engaged in collaborations exploring interactions between breast cancer cells and adipocyte derived stem cells, as well as developing ex-vivo models of the breast tumor microenvironment. Show less

Principle Investigator: Randall KopperDeveloped assays to identify differential hyaluronidase activity in snake venom.

Doctor Of Philosophy (Phd), Biomedical Sciences, General

Bachelor Of Arts (Ba), Biochemistry And Molecular Biology