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Biotechnology professional with experience in molecular and cellular biology, bioinformatics, protein expression technologies, transgenics, cell line development, small and large scale cell culture and harvest, manufacturing scale-up and process transfer, project managment, business development, and contract manufacturing.
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Associate DirectorSeagenBothell, Wa, Us
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RetirementCareer Break May 2024 - Present
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DirectorPfizer Jan 2024 - May 2024New York, New York, Us -
DirectorSeagen Jul 2021 - Jan 2024Bothell, Washington, Us
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Associate DirectorSeagen May 2019 - Jul 2021Bothell, Washington, Us
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Principal ScientistSeagen Sep 2015 - May 2019Bothell, Washington, Us
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Director, Upstream Process DevelopmentCmc Icos Biologics, Inc. Jan 2011 - Sep 2015Bothell, Wa, UsHead of Upstream and Cell Line Development group. Provided technical and operational guidance in the development and optimization of CHO cell lines expressing recombinant therapeutic antibodies and glycoproteins. • Lead CHEF1 technical improvements and innovation within the department to ensure the competitiveness of the company. Published and presented at international scientific meetings.• Provided technical leadership and strategic planning for contract project execution including cell line development, small scale bioreactor development, process optimization and transfer to manufacturing.• Provided cell culture process and technical guidance to Quality Assurance, Manufacturing, and Engineering in support of transfer and deviation investigations. • Supported commercial validation efforts through method qualification and process characterization, statistical evaluation and associated regulatory filings. Provided subject matter expertise for regulatory filings and inspections.• Supported Business Development and Project Management in scoping of new projects, identifying and evaluating new business opportunities. Managed new client project planning and execution. -
Principal Development ScientistCmc Icos Biologics, Inc. Mar 2008 - Jan 2011Bothell, Wa, UsManaged group to improve CHEF1 expression platform through new vector design, cell culture media optimization, host cell improvements and clonal cell line selection methodologies.
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Staff ScientistUniversity Of Washington 2003 - 2008Seattle, Wa, UsConducted research studying dynamic organization of cytoskeletal proteins during cytokinesis in early Caenorhabditis elegans embryos. Focused primarily on the role of actin and myosin in establishment and maintenance of zygotic asymmetry of polarity proteins. -
Staff ScientistAmgen 2001 - 2003Thousand Oaks, Ca, UsVector Engineering: Improved and implemented technologies for cloning and expressing single chain variable fragments from phage libraries into multiple antibody platforms including IgGs, Fabs, and tagged-fusions. -
Staff ScientistImmunex 1994 - 2001UsResearched technologies to improve expression and product quality of recombinant therapeutic proteins in yeast and mammalian cells, including expression vector design and development, clonal cell line selection, protein engineering and improved secretion.Protease Biology: Developed new PCR technologies to create mutant protease libraries and screen for altered enzyme activities. Mined the human genome database to identify and clone novel proteases and protease inhibitors. -
Research AssociateGladstone Foundation For Cardiovascular Disease 1986 - 1988Researched molecular genetics of human apoplipoprotein genes.
Howard Clarke Skills
Howard Clarke Education Details
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University Of WashingtonCell And Molecular Biology -
San Francisco State UniversityMicrobiology
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San Francisco State UniversityMarine Biology
Frequently Asked Questions about Howard Clarke
What company does Howard Clarke work for?
Howard Clarke works for Seagen
What is Howard Clarke's role at the current company?
Howard Clarke's current role is Associate Director.
What is Howard Clarke's email address?
Howard Clarke's email address is ho****@****ics.com
What is Howard Clarke's direct phone number?
Howard Clarke's direct phone number is +142548*****
What schools did Howard Clarke attend?
Howard Clarke attended University Of Washington, San Francisco State University, San Francisco State University.
What skills is Howard Clarke known for?
Howard Clarke has skills like Cell Culture, Biotechnology, Protein Expression, Life Sciences, Biopharmaceuticals, Molecular Biology, Monoclonal Antibodies, Antibodies, Cell Biology, Protein Chemistry, Assay Development, Bioinformatics.
Who are Howard Clarke's colleagues?
Howard Clarke's colleagues are Amy Olofson, Auria Coons-Hale, Kathryn Culbert, Kathya Kalinine, Lori Ginter, Karen Pranis, Micah Nakao.
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