Hubert Lam Email & Phone Number

Cambridge, Ma, Us

Watertown, Massachusetts, Us

• Program Lead, Adoptive cell therapy program for solid tumors o Autologous T cell therapy using the ATLAS bioassay to identify neoantigens for the rapid expansion of tumor-specific CD4+ and CD8+ T cells from peripheral blood o Lead program team responsible for strategy and execution to IND and FIH studies across nonclinical, clinical, CMC, and regulatory functions o Drive timelines, budget, and manage program risk reporting directly to the executive team• Preclinical Research Department Head: o Direct preclinical PoC and MoA studies for cancer immunotherapies (e.g. in vivo immunogenicity and tumor efficacy, in vitro cytotoxicity, TIL phenotyping, T cell expansion, immune monitoring) o Lead IND-enabling studies (Pharmacology, PK, Tox) for regulatory filings across next-generation cancer vaccine and cell therapy programs o Manage projects across CROs and external collaborators; Lead team of 6 reports o Successful IND for personalized neoantigen cancer vaccine program

Vaccine Development Group Leader, Immuno-oncology Lead nonclinical development for personalized cancer vaccine programincluding in vivo models, adjuvant selection, dose/regimen, and potencyassay development; lead multiple projects with CROs and externalcollaborators; core member of cross-functional program team supportingIND strategy and filing; manage a team of 5 reports

Paris, France, Fr

• Principal Investigator of Chlamydia Exploratory Vaccine Program• Developed and executed chlamydia infection models; developed in vitro neutralization assay using a novel, engineered reporter strain, identifying lead vaccine candidates • Led research activities internally and externally to achieve project milestones; aligned strategy with senior management; research lead on global project team responsible for developing target product profile, marketing, and clinical strategy

Paris, France, Fr

Research Scientist with the primary objective of developing new vaccines for the prevention and treatment of infectious disease. • Coagulase Negative Staphylococci Exploratory Vaccine Program• Developed imaging platform for quantifying anti-biofilm vaccines and therapeutics, identifying a lead vaccine candidate. • Collaborated across internal functional groups and external partners

Boston, Ma, Us

Advisor: Matthew Waldor, Professor/HHMI Investigator• Identification and analysis of cell wall regulating small molecules in the pathogenic bacterium Vibrio cholerae. Discovered previous unrecognized bacterial production and release of D-amino acids, which act as inhibitors of cell wall metabolism for community adaptation to stress.

New Haven, Ct, Us

Advisor: Dr. Christine Jacobs-Wagner, Associate Professor/HHMI Investigator• Identification of mechanisms that regulate bacterial polarity and cell cycle progression. Uncovered novel mechanisms of bacterial cell signaling through spatial and temporal distribution of regulatory proteins.

New Haven, Ct, Us

Teaching assistant in Microbiology - Taught, designed and graded laboratory exercises - Instructed laboratory techniques and analyses

Waterville, Maine, Us

Advisor: Dr. Arthur Champlin, ProfessorOptimizing the fertilizing potential of frozen mouse gametes by cryopreservation-Used in vitro fertilization of frozen mouse gametes to quantify the efficiency of cryopreservation.

Worcester, Ma, Us

Advisor: Dr. Craig Mello, Professor/Nobel Laureate/HHMI investigatorMechanisms of RNA interference in Caenorhabditis elegans -Contributed to the genetic mapping of several RNA interference-deficient mutants

Ph.D., Molecular, Cellular And Developmental Biology

B.A., Biology