Development of new ligands for a-synuclein imaging in Parkinson’s diseaseBiochemistry assays and protein production at MIRCen, Neurodegeneratives diseases laboratory (UMR 9199, CEA, CNRS)Organic chemistry at SCBM, LMT (Molecular Labeling and Bio-organic Chemistry unit, Tritium Labeling Laboratory, CEA)

Topic : Bioorthogonal chemistry applied to Drug decaging Synthesis of Iminosydnones derivatives and evaluation of their reactivity with strained alkyne through Click and Release reaction (1,3-Dipolar Cycloaddition followed by Retro Diels-Alder reaction)Skills : Chemistry : - Multi-step synthesis - Iminosydnones chemistry - Click chemistryChromatography purification methods (Column, Flash chromatography)Characterization of molecules (NMR, HPLC-MS, IR, MP)

Topic : Identification of type XIII collagen receptors and characterisation of its binding sitesType XIII Collagen ligand screening by affinity tests on peptides coated plateSynthesis of homotrimeric helical peptides needed for binding assaysChemistry : - Solid Phase Peptide Synthesis (Liberty Blue™) - Liquid Phase Peptide SynthesisAnalysis : - Maldi-ToF (MassLynx Software) - Reverse phase preparative HPLC / analytical HPLC - Triple helical peptides denaturation midpoint determination by polarimetryBiochemistry :- ELISA assays of receptor binding to triple helical peptides- Cell binding to triple helical peptides

Topic : Development of radioimmunoconjugated using 195mPt in a theranostic approach about ovarian cancer Protein-Cytotoxic drug Linker synthesisChemistry : - Multi-step synthesis - liquid phase peptide synthesisChromatography purification methods (Column, Flash chromatography)Characterization of molecules (NMR, HPLC-MS)

Topic : Synthesis, Purification and Analysis of Cytosolic Nucleotidase 2 inhibitors Synthesis of new Nucleotidic Cardoxamido-Aryl derivativesChemistry : - Multi step synthesis - Heterocyclic chemistryChromatography purification methods (Column, Flash chromatography)Characterization of molecules (NMR, HPLC-MS)

Topic : Synthesis, Purification and Analysis of Kallicreine 6 inhibitors Chemistry : - Multi step synthesisChromatography purification methods (Column, Flash chromatography)Characterization of molecules (NMR, HPLC-MS)

Study of the effect of freeze-drying on super desintegrants

Formulation study of melatonine tablet