In charge of the protein production and characterization by using in vivo and in vitro assay.QC the small molecules by cell based asssay.Participate the product development and promoting the products sale.Technical support for client.

In charge of the design, production and quality control of more than 20 growth/differentiation factors including WNT-3a, SHh, TGF-beta family protein and PDGF-BB* Improved productivity of multiple difficult expression proteins through protein engineering, stable cell line development, and optimization of the refolding process, etc.* Improved the yield of SHh protein by more than 20-fold* Established innovative protocol for increasing WNT-3a expression and purity to 95% * Established process for expressing/purifying native and refolded recombinant proteins from the E.coli system* Developed multiple biochemical assays and cell-based assays for QC recombinant proteins* Optimized media for ES and iPS cell maintenance/differentiation* Train and supervise technicians on protein expression and purification* Communicate with marketing department and provide technical support* Participate in business development

Study the role of transcription elongation factor in stem cell maintenance by applying esiRNA knockdown and over expression a dominant-negative form of the elongation factorStructural and functional analysis of the transcriptional elongation factors in zebrafish development

Studied the mechanism of ubiquitin independent protein degradation by 26S proteasomeCompared the functions of antizyme1 and 2 in protein degradation Defined the elements in antizyme1 critical for ornithine decarboxylase degradation