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Matt Hurley Email & Phone Number
Scientist II
at
VidaVinci, Inc.
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✓ Verified August 2026
3 data sources
Profile completeness 86%
Current company
Role
Scientist II
Location
Philadelphia, Pennsylvania, United States
Company size
Who is Matt Hurley? Overview
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Matt Hurley is listed as Scientist II at VidaVinci, Inc., a with 22 employees, based in Philadelphia, Pennsylvania, United States. AeroLeads shows a matched LinkedIn profile for Matt Hurley.
Matt Hurley previously worked as Scientist at Stealth Biotech and Scientist at Nested Therapeutics. Matt Hurley holds Doctor Of Philosophy - Phd, Chemistry from Temple University.
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VidaVinci, Inc.
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Profile bio
About Matt Hurley
As an accomplished Computational Chemist, I specialize in lead optimization and the application of advanced computational techniques to enhance drug discovery processes. With a strong foundation in molecular dynamics simulations, free energy perturbation calculations, and both ligand- and structure-based drug design, I bring a wealth of expertise and innovation to the field.During my tenure at the Voelz Lab at Temple University, I utilized open-source MD frameworks through Folding@Home to conduct all-atom, long-timescale molecular dynamics simulations, evaluating the binding mechanisms and kinetics of protein-ligand complexes as well as evaluating Expanded Ensemble free energy calculations for thousands of compounds in partnership with the COVID Moonshot mission.At Nested Therapeutics, I contributed to multiple programs using a diverse array of tools ranging from literature- and modeling-based target assessment, deploying ligand FEP to evaluate binding affinities, stability- and affinity-based Protein FEP to predict resistance mutations, conducting SAR trend analyses to inform prospective design, matched pair analyses, and ADME property predictions.I have also worked to reconcile simulated structures with experimental observables (HDX/NMR) and re-weight simulated ensembles and generate relevant conformers to bolster understanding of protein dynamics.My technical skills encompass:Software Programming (Python & Bash)GNU/Unix, HPC, AWS ExpertiseSchrodinger Suite, D360, KNIMEAll-Atom Molecular Dynamics SimulationsFree Energy CalculationsMachine-Learning / Generative AIIn addition to my core expertise, I have a keen interest in:Incorporating generative deep-learning methods to design novel and optimized drug candidates.Integrating GPU acceleration into computational methods.Developing virtual and augmented reality applications for molecular modeling and drug design.Exploring breakthroughs in Natural Language Processing and refinement of LLMs.With strong project and cluster administration skills, I have overseen software upgrades, expanded scientific workflow documentation, and mentored team members. My interpersonal communication abilities further enhance my collaborative and leadership capabilities.I am passionate about pushing the boundaries of computational chemistry and drug discovery, constantly seeking innovative solutions and staying abreast of the latest advancements in the field.
Current workplace
Matt Hurley's current company
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Vidavinci, Inc.
4 roles
Matt Hurley work experience
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Scientist
Scientist
Assisted in lead optimization by validating and optimizing free energy perturbation (FEP) maps, (absolute & relative) towards prioritization of candidate compounds on a vector-specific basis.Enumeration of designs, assessed via docking and ADME property prediction resulted in a streamlined filtering ahead of FEP.Managed datasets for post-synthesis tracking of virtual compounds, increasing enrichment of synthesis queue.Deployed stability- and affinity-based Protein FEP to predict resistance for all proximal single-codon mutations.Initiated short time-scale MD simulations to generate working structure-based hypotheses to correlate with observed selectivity.Uncovered SAR trends through R-group decomposition and matched pair analyses using D360 to inform prospective design.Deployed long timescale MD simulations to establish differential dynamics and pocket formation across Zn-compromising p53 mutations.Reconciled simulated structures with experimental HDX observables using ensemble re-weighting to generate relevant conformers. Aided the platform team in evaluating prospective protein targets based on pre-existing literature, modeling, and pocket identification.Oversaw upgrading and testing of new software installations, presenting recent releases to the broader team.Expanded existing documentation for scientific workflows and HPC cluster administration tasks.
Sep 2022 - Nov 2024
Research Assistant
Research Projects:Reconciling experimental observables with simulation data towards structure prediction of cyclic peptidomimetics using Bayesian inference.Conformational stability assessment of fluorinated peptoids via ab initio quantum mechanics calculations of molecular orbital interactions.Estimation of protein-ligand binding kinetics, pathways, and state populations from molecular dynamics using dimensionality reduction methods and Markov state models.Deployment and analysis of high-throughput absolute free energy simulations towards binding affinity predictions for small molecular inhibitors of SARS-CoV-2 on Folding@home as part of the Postera Moonshot Consortium.Development of a novel ligand restraint protocol and optimization of expanded ensemble enhanced sampling methodology.Participation in SAMPL9 host-guest challenge for estimating thermodynamics of binding interactions.Installation, administration, and maintenance of Folding@home work servers.Folding@home community outreach, moderation, and mentorship.TA assignments:General Chemistry Lab I/IIGeneral Chemistry II RecitationPhysical Chemistry of BiomoleculesTechniques of Chemical Measurement IIEmerging STEM Scholars I/II
Aug 2015 - Oct 2022
2 education records
Matt Hurley education
Doctor Of Philosophy - Phd, Chemistry
Temple University
Bachelor'S Degree, Chemistry
Fordham University
FAQ
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What company does Matt Hurley work for?
Matt Hurley works for VidaVinci, Inc..
What is Matt Hurley's role at VidaVinci, Inc.?
Matt Hurley is listed as Scientist II at VidaVinci, Inc..
Where is Matt Hurley based?
Matt Hurley is based in Philadelphia, Pennsylvania, United States while working with VidaVinci, Inc..
What companies has Matt Hurley worked for?
Matt Hurley has worked for Vidavinci, Inc., Stealth Biotech, Nested Therapeutics, and Temple University.
How can I contact Matt Hurley?
You can use AeroLeads to view verified contact signals for Matt Hurley at VidaVinci, Inc., including work email, phone, and LinkedIn data when available.
What schools did Matt Hurley attend?
Matt Hurley holds Doctor Of Philosophy - Phd, Chemistry from Temple University.
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