I-Chung Lo

I-Chung Lo Email and Phone Number

Drug Discovery | Certified Data Analyst @ Degron Therapeutics
I-Chung Lo's Location
San Diego County, California, United States, United States
I-Chung Lo's Contact Details

I-Chung Lo personal email

n/a
About I-Chung Lo

Experienced leader in translational science with a strong background in leveraging cutting-edge ML/AI technologies for drug discovery and development. Proven track record of advancing small molecules from target validation to IND applications. Skilled in leveraging Translational Medicine, Oncology, Genomics, Biomarkers, and Databases to drive medical advancements and improve patient outcomes. Experienced in collaborating with CROs and internal program teams. Proficient in data analytics, including R and Python programming and Power BI, and certified as a Microsoft Data Analyst.Specialties:Translational Medicine | NGS | High throughput Screening | Preclinical Research | Assay Development | Genome Editing | Data Analysis with R, Python and Power BI | Power BI Certified by MS

I-Chung Lo's Current Company Details
Degron Therapeutics

Degron Therapeutics

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Drug Discovery | Certified Data Analyst
I-Chung Lo Work Experience Details
  • Degron Therapeutics
    Associate Director Of Translational Science
    Degron Therapeutics Oct 2022 - Present
    - Translational and biomarker studies in oncology.- Conduct MOA studies of target protein degradation.- Lead and manage a team of PhD-level scientists. Collaborate with cross-functional teams to advance therapeutic candidates.- Application of ML/AI to predict DMPK properties of small molecules, improving drug development pipelines.- Advanced ligand-protein docking modeling using PyMOL, ChimeraX, DiffDock, and AF3, enabling accurate molecular interaction predictions.
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  • Trotana Therapeutics
    Principal Scientist
    Trotana Therapeutics Feb 2022 - Sep 2022
    San Diego, California, Us
    - Provided specialized expertise in omics-genomics analysis to support translational research initiatives.- Worked closely with the Chemistry Department to identify and validate targets for oncology and neurodegeneration.
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  • Vividion Therapeutics. Inc.
    Senior Scientist
    Vividion Therapeutics. Inc. Jan 2021 - Mar 2022
    San Diego, Ca, Us
    - Led early discovery and translational science programs in oncology.- Designed and executed a wide range of cell-based assays and implemented assay automation.- Collaborated with multi-functional drug discovery project teams.- Conducted high-quality in vitro studies to evaluate novel targets and screen multi-modality drug candidates.- Used bioinformatics and R programming for data mining and predicting drug sensitivity.
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  • Vividion Therapeutics. Inc.
    Scientist Ii
    Vividion Therapeutics. Inc. Sep 2018 - Dec 2020
    San Diego, Ca, Us
    - Identified and validated drug targets in early discovery science.- Coordinated projects across departments and utilized new technology and assays to support drug discovery.
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  • Takeda Pharmaceuticals
    Staff Scientist
    Takeda Pharmaceuticals Jan 2016 - Sep 2018
    Tokyo, Jp
    - Developed tool assets for early target ID/Validation, including disease cell models and assays for HTS.- Identified novel drug targets and validated them through high-throughput assays.
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  • University Of California, San Diego
    Assistant Project Scientist
    University Of California, San Diego Jan 2015 - Dec 2015
    La Jolla, Ca, Us
    • Developed an in vitro collagen transportation assay for quantification and delineate successfully mechanisms of fibrosis progress. Commonly used techniques included cell culture, transfection, virus infection, DNA isolation, PCR, real-time PCR, SDS-PAGE, Western blot and immunofluorescence. • Discovered GIV, a metastasis-related protein, as a key of integrin activation and a biomarker for metastatic cancer cells. Commonly used techniques included mutagenesis, RT-PCR/qPCR, Flow cytometry/FACS, Confocol microscopy.• Built and maintained collaborations. Supervised research associates and technicians.
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  • University Of California, San Diego
    Post-Doctoral Fellow
    University Of California, San Diego Jan 2010 - Dec 2014
    La Jolla, Ca, Us
    • Led a project to discover GIV, a non-receptor G protein activator, activating G proteins at the Golgi, thereby undermining the long held-belief that G proteins are activated exclusively by GPCRs at the PM. Commonly used techniques included surface biotinylation, receptor internalization and transportation, analyzing G protein signaling pathway assays. • Developed an in vitro system to investigate how G protein signaling affecting vesicle trafficking.• Helped to acquire a 5-year NIH R01 grant and managed grant based research.
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I-Chung Lo Skills

Western Blotting Molecular Biology Cell Biology Biochemistry Immunoprecipitation Molecular Cloning Immunofluorescence Confocal Microscopy Protein Expression Fluorescence Microscopy Elisa Purification Protein Chemistry Microscopy Biotechnology Tissue Culture Flow Cytometry Neuroscience Bioinformatics Qpcr Rt Pcr Scientific Writing Western Blot Rna Isolation Systems Biology Developmental Biology Computational Biology Cancer Research Fluorescence Spectroscopy Sequence Analysis Stem Cells Rat And Mouse Animal Model Adenovirus Preparation Lentivirus Metabolic Labeling Rna Seq Ngs Analysis Bret Assay Next Generation Cloning Graphpad Prism Drug Metabolism And Pharmacokinetics Cell Line Generation Chip Seq High Content Imaging High Throughput Screening R Programming Pharmaceutics Biologics Cell Culture Rnai Mass Spectrometry Gel Electrophoresis Hplc Pcr

I-Chung Lo Education Details

  • National Cheng Kung University
    National Cheng Kung University
    Cardiology

Frequently Asked Questions about I-Chung Lo

What company does I-Chung Lo work for?

I-Chung Lo works for Degron Therapeutics

What is I-Chung Lo's role at the current company?

I-Chung Lo's current role is Drug Discovery | Certified Data Analyst.

What is I-Chung Lo's email address?

I-Chung Lo's email address is il****@****ion.com

What schools did I-Chung Lo attend?

I-Chung Lo attended National Cheng Kung University.

What skills is I-Chung Lo known for?

I-Chung Lo has skills like Western Blotting, Molecular Biology, Cell Biology, Biochemistry, Immunoprecipitation, Molecular Cloning, Immunofluorescence, Confocal Microscopy, Protein Expression, Fluorescence Microscopy, Elisa, Purification.

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