I-Chung Lo Email & Phone Number

- Translational and biomarker studies in oncology.- Conduct MOA studies of target protein degradation.- Lead and manage a team of PhD-level scientists. Collaborate with cross-functional teams to advance therapeutic candidates.- Application of ML/AI to predict DMPK properties of small molecules, improving drug development pipelines.- Advanced ligand-protein docking modeling using PyMOL, ChimeraX, DiffDock, and AF3, enabling accurate molecular interaction predictions.

San Diego, California, Us

- Provided specialized expertise in omics-genomics analysis to support translational research initiatives.- Worked closely with the Chemistry Department to identify and validate targets for oncology and neurodegeneration.

San Diego, Ca, Us

- Led early discovery and translational science programs in oncology.- Designed and executed a wide range of cell-based assays and implemented assay automation.- Collaborated with multi-functional drug discovery project teams.- Conducted high-quality in vitro studies to evaluate novel targets and screen multi-modality drug candidates.- Used bioinformatics and R programming for data mining and predicting drug sensitivity.

San Diego, Ca, Us

- Identified and validated drug targets in early discovery science.- Coordinated projects across departments and utilized new technology and assays to support drug discovery.

Tokyo, Jp

- Developed tool assets for early target ID/Validation, including disease cell models and assays for HTS.- Identified novel drug targets and validated them through high-throughput assays.

La Jolla, Ca, Us

• Developed an in vitro collagen transportation assay for quantification and delineate successfully mechanisms of fibrosis progress. Commonly used techniques included cell culture, transfection, virus infection, DNA isolation, PCR, real-time PCR, SDS-PAGE, Western blot and immunofluorescence. • Discovered GIV, a metastasis-related protein, as a key of integrin activation and a biomarker for metastatic cancer cells. Commonly used techniques included mutagenesis, RT-PCR/qPCR, Flow cytometry/FACS, Confocol microscopy.• Built and maintained collaborations. Supervised research associates and technicians.

La Jolla, Ca, Us

• Led a project to discover GIV, a non-receptor G protein activator, activating G proteins at the Golgi, thereby undermining the long held-belief that G proteins are activated exclusively by GPCRs at the PM. Commonly used techniques included surface biotinylation, receptor internalization and transportation, analyzing G protein signaling pathway assays. • Developed an in vitro system to investigate how G protein signaling affecting vesicle trafficking.• Helped to acquire a 5-year NIH R01 grant and managed grant based research.