Ian Scott, Phd, Frsc, Cchem

Ian Scott, Phd, Frsc, Cchem Email and Phone Number

VP CMC at Enliven Therapeutics @ Enliven Therapeutics
Ian Scott, Phd, Frsc, Cchem's Location
Denver Metropolitan Area, United States, United States
Ian Scott, Phd, Frsc, Cchem's Contact Details

Ian Scott, Phd, Frsc, Cchem work email

Ian Scott, Phd, Frsc, Cchem personal email

n/a
About Ian Scott, Phd, Frsc, Cchem

My scientific and leadership experience stems from over 25 years of intense, fast-paced direction of research and development teams for both pharmaceutical and contract research organizations. I bring creativity and scientific discipline to the invention of new medicines, and offer a proven track record of success:• Invention of the very first oral, non-retinoid to progress to Phase IIB/III clinical trials for AMD (Emixustat)• Team leader/principal inventor 3 clinical candidates•Head of all non-clinical R&D for Emixustat program (Medicinal and Process Chemistry, Biology, DP formulation and manufacture, analytical, intellectual property, ADME-PK and toxicology). API Development team leader for 16 programs (IND, ANDA and NDA filings)• Author API section for successful NDA filing of Belinostat (Beleodaq)• 35 Issued US patents• 34 Publications and presentations • 6 Invited speaking engagements; Session chair, Neuron to Synapse 2010From R&D to operations, I provide a wide range of scientific knowledge, cross-functional leadership, and management expertise to every aspect of drug discovery and development. My work includes the achievement of ambitious corporate and scientific goals with teams numbering from a just a few scientists, to as many as 60 staff distributed among global research sites. My specialty is the integration of all aspects of drug discovery, from early-stage research in medicinal chemistry, through patent protection, pre-clinical development, API process development and CMC filing from IND through NDA.Specialties: Neurological disease / neurodegeneration ~ Ophthalmic disease ~ Cancer ~ Inflammation {Retinoid Isomerization, RPE65, Kinases (P38, MAPKAP2, MK-2), NMDA, Dopamine D2, Growth Factors (FGF, VEGF), HDAC, Serotonin, Integrin VLA-4/alpha4beta1, PTP-1B, Endothelin A, GABA, E-Selectin, beta-Secretase}

Ian Scott, Phd, Frsc, Cchem's Current Company Details
Enliven Therapeutics

Enliven Therapeutics

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VP CMC at Enliven Therapeutics
Ian Scott, Phd, Frsc, Cchem Work Experience Details
  • Enliven Therapeutics
    Vp Cmc
    Enliven Therapeutics Mar 2021 - Present
    Boulder, Co, Us
  • Zentalis Pharmaceuticals
    Head Of Process Chemistry
    Zentalis Pharmaceuticals Jul 2020 - Mar 2021
    New York, Ny, Us
  • Chemelian
    Owner And Principal Consultant
    Chemelian Oct 2019 - Mar 2021
    Chemelian is a consulting company specializing in providing program management and technical support for the discovery and development of new small molecule therapeutics.Technical ExpertiseI. Program management of all CMC activities (API, drug product and analytical)II. Management of chemical outsourcing (North America, Europe, India and China)III. Medicinal chemistry IV. Phase appropriate development of API processes and drug product formulations from pre-IND to validationV. GMP ManufactureVI. Authorship of patent applicationsVII. Authorship of CMC regulatory filings
  • Pfizer Boulder Research And Development (Array Biopharma)
    Cmc Manufacturing Head
    Pfizer Boulder Research And Development (Array Biopharma) Feb 2019 - Dec 2019
    New York, New York, Us
    Roles and ResponsibilitiesI. Establishment and leadership of CMC teamII. Direction of chemical development activities (API, analytical and drug product) for all development programs from pre-IND through to Phase 3 (8 compounds)III. Authorship of IND filingsIV. Interface with medicinal chemistry for rapid advancement of pre-clinical programs
  • Astex Pharmaceuticals
    Senior Director, Process Chemistry
    Astex Pharmaceuticals Apr 2017 - Feb 2019
    Pleasanton, Ca, Us
    Roles and ResponsibilitiesI. Leadership of API departmentII. Management of API manufacture from new route discovery through process validation (5 programs)III. Management of pre-validation activities for 2 programs – fate and purge studies, establishment of NOR/PAR parameters, process quality risk assessment and setting of specificationsIV. Authorship of IND filings
  • Corcept Therapeutics
    Director Of Chemical Development
    Corcept Therapeutics Dec 2014 - Mar 2017
    Redwood City, California, Us
    Roles and ResponsibilitiesI. Direction of all chemical development activities for 4 compoundsII. Management of API manufacture from new route discovery through process optimization and GMP manufactureIII. Management of formulation development and drug product manufactureIV. Authorship of API and DP sections of IND and EU filingsV. Management of chemistry outsourcing (EU, North America, China)VI. Design of novel glucocorticoid receptor antagonists
  • Allergan
    Director Of Process Chemistry
    Allergan Apr 2014 - Oct 2014
    Dublin, Coolock, Ie
    Roles and ResponsibilitiesI. Responsible for all stages of API manufacture, from new route discovery through process optimization and GMP manufacture.II. Management of chemistry outsourcing relationships (EU, North America, India)III. Integration of process and medicinal chemistry programsIV. Design of novel prostaglandins
  • Spectrum Pharmaceuticals
    Director Of Chemical Development
    Spectrum Pharmaceuticals Dec 2011 - Apr 2014
    Lake Forest, Illinois, Us
    Spectrum is a mid-size pharmaceutical company focused on the development of new drugs to treat cancer. As Head of Chemical Development I was responsible for all API-related activities. This includes oversight of API manufacture and preparation of CMC regulatory documents (IND, DMF, ANDA, NDA (Belinostat/Beleodaq)).
  • Acucela Inc.
    Senior Director, Chemistry And Biology
    Acucela Inc. Nov 2005 - Jan 2011
    Seattle, Wa, Us
    Acucela is a biotechnology company focused on the discovery of new, small-molecule therapeutics for the treatment of blinding eye diseases. Acucela’s programs include: the Visual Cycle Modulator program for the treatment of Age-Related Macular Degeneration (AMD), which was out-licensed to Otsuka Pharmaceutical Company, Japan; and two in-licensed programs for the treatment of dry eye and glaucoma.I began my career at Acucela as the Director of Chemistry in 2005, shortly after Acucela in-licensed retinyl amide (ACU-3223) from the University of Washington for the treatment of AMD. In 2006, I assumed responsibility for the Next Generation Visual Cycle Modulator Program with the goal of identifying a non-retinoid modulator of the visual cycle (inhibitor of the isomerase enzyme RPE65). This program led to the invention of ACU-4429; currently in Phase 2 clinical trials for the treatment of AMD. In 2008, I was promoted to Senior Director of Chemistry and Biology, and assumed responsibility for all non-clinical research and development. My additional executive roles included Acting Head of Toxicology and ADME, and Head of Intellectual Property. I was a member of the Joint Development Committee for collaboration with Otsuka Pharmaceuticals, and in 2009, received The Dr. Kubota Award for outstanding achievement.
  • Amri
    Group (Executive) Director, Lead Discovery / Head Of Operations
    Amri 1999 - 2005
    Albany, Ny, Us
    My career at AMRI began in the Medicinal Chemistry Group as Section Head (1999). I was responsible for projects in many therapeutic areas and became Team Leader for all contracted projects with two global pharmaceutical companies. A large part of my research was focused on the treatment of neurological disorders including several neurodegenerative diseases. In 2002, as Assistant Director of Medicinal Chemistry, I was responsible for ~30 chemists (mostly Ph.D.) divided between 6 external and 2 internal research teams. During my tenure in the Medicinal Chemistry Group, I established and ran The Oncology Group. My oversight of this group continued as my career progressed beyond medicinal chemistry and led to the identification of a clinical candidate.In 2003, I was promoted to Group Director, Discovery and relocated to Bothell, WA as Head of Operations of the Bothell Research Center. Later that year, my responsibilities increased to include The Biosciences Group, Chicago.
  • Texas Biotechnology Corporation
    Associate Director
    Texas Biotechnology Corporation 1992 - 1999
    Texas Biotechnology Corporation was focused on the creation of new new drugs to treat cardiovascular and inflammatory diseases. Targets included the selectins, integrins and growth factors.Principal inventor and team leader for the discovery of TBC-4746 (progressed to Phase II for the treatment of multiple sclerosis).Medicinal Chemistry team leader for integrin, VEGF and FGF programs.Developed commercially viable route to Bimosiamose
  • Florida State University
    Post Doctoral Student
    Florida State University Mar 1989 - Sep 1992
    Tallahassee, Fl, Us
    Increased understanding of the mechanism of the Pauson-Khand reaction and expansion of its synthetic utility.Advisor: Prof. Marie Krafft

Ian Scott, Phd, Frsc, Cchem Skills

Research And Development Clinical Trials Drug Design Cro Chemistry Neurodegeneration Gmp Neuroscience Biotechnology Cell Regulatory Affairs Drug Discovery Cro Management Oncology Drug Development Clinical Development Cancer Medicinal Chemistry Pharmaceutical Industry Technology Transfer Toxicology R&d

Ian Scott, Phd, Frsc, Cchem Education Details

  • The University Of Sheffield
    The University Of Sheffield
    Chemistry
  • The University Of Sheffield
    The University Of Sheffield
    Chemistry
  • The University Of Sheffield
    The University Of Sheffield
    Chemistry

Frequently Asked Questions about Ian Scott, Phd, Frsc, Cchem

What company does Ian Scott, Phd, Frsc, Cchem work for?

Ian Scott, Phd, Frsc, Cchem works for Enliven Therapeutics

What is Ian Scott, Phd, Frsc, Cchem's role at the current company?

Ian Scott, Phd, Frsc, Cchem's current role is VP CMC at Enliven Therapeutics.

What is Ian Scott, Phd, Frsc, Cchem's email address?

Ian Scott, Phd, Frsc, Cchem's email address is is****@****ier.com

What schools did Ian Scott, Phd, Frsc, Cchem attend?

Ian Scott, Phd, Frsc, Cchem attended The University Of Sheffield, The University Of Sheffield, The University Of Sheffield.

What skills is Ian Scott, Phd, Frsc, Cchem known for?

Ian Scott, Phd, Frsc, Cchem has skills like Research And Development, Clinical Trials, Drug Design, Cro, Chemistry, Neurodegeneration, Gmp, Neuroscience, Biotechnology, Cell, Regulatory Affairs, Drug Discovery.

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