Irina Ramos Email & Phone Number

United States

Cambridge, Cambridgeshire, Gb

Focus on CMC development and innovation, leading a team of scientists to evolve downstream bioprocesses into integrated and continuous mode. Next Generation Manufacturing.

Newark, De, Us

• Project overview - https://niimbl.my.site.com/s/nmbl-2000• Paper - https://doi.org/10.1002/bit.27688Focus on rapid bioburden testing and closed systems for continuous bioprocessing.

Baltimore, Md, Us

BTEC658 - Principles in Downstream ProcessingBTEC 658 is a comprehensive study of fundamentals of downstream processing for biochemical products recovery and formulation. Specifically focuses on purification process design and optimization to separate, concentrate and recover a desired product (enzymes, chemicals, pharmaceuticals, novel protein constructs) for its intended use. Integration of innovation in process development, scale-up and facility fit, and commercial process goals under good manufacturing practices is also presented using case studies and publications form reliable sources.Topic areas to be discussed include:(1) learning traditional unit operations, new concepts and emerging technology and their benefits to biochemical product recovery (principles of centrifugation, chromatography, filtration, membrane processes, introduction to continuous processing);(2) assessing the impact of change in unit operations on the process and product quality attributes; (3) examining analytical and process validation issues that are critical to successful manufacturing in large scale a high-purity and high-quality protein; (4) addressing strategy on formulation development and stability; and (5) highlighting validation and regulatory concerns related to downstream process implementation.

Cambridge, Cambridgeshire, Gb

Focus on CMC development and innovation, leading a team of scientists to evolve downstream bioprocesses into integrated and continuous mode. Next Generation Manufacturing.

Cambridge, Cambridgeshire, Gb

 Purification process characterization and validation for multiple mAbs. Lead a team of scientists. Authored regulatory filings, responded questions from Regulatory authority. Experience with development, scale-up and improving product purifications for commercialization. Involvement and leadership in cross-functional teams (CMC, technology development, department improvement and maintenance). Bridging gaps with Process Cell Culture, Analytical Biochemistry, Formulation Science, Scale-up, Clinical Manufacturing, Commercial Manufacturing and Fit-to-Plant groups. Development of tools to assess process risk and implement novel technologies: academic laboratory and external Industry collaborations, as well as internal collaborations.  Analytical and preparative chromatography: Ion-exchange, mixed-mode, protein A, reversed-phase, size exclusion, immobilized metal-affinity, hydrophobic interaction, weak partitioning, capillary zone electrophoresis, membrane separations, and others. Automation, JMP statistical analysis and robotic high-throughput instrumentation expertise for DOE and QbD applications.  Mentor peers to get new scientists on-board, cross-functional career development and awareness about process development requirements and deliverables.

Gaithersburg, Maryland, Us

Protein purification process developer, supporting tech transfer activities into cGMP manufacturing to supply clinical trials. Process Optimization.CMC team member. Contribute to IND submissions

Gaithersburg, Maryland, Us

Protein purification process developer, supporting tech transfer activities into cGMP manufacturing to supply clinical trials.CMC team member. Contribute to IND submissions

Baltimore, Md, Us

BTEC 653 - Applied Bioprocessing EngineeringA chemical engineering course covering basic process engineering, from the milliliter to the kiloliter scale. Topics relevant to the commercial bioprocesses used in the food, pharmaceutical and waste treatment industries will be introduced. Both upstream processes (e.g., fermentation, cell growth, energetics, mass transfer and enzyme kinetics) and downstream processes (chromatographic separations, ultrafiltration and waste treatment) were covered.

Co-chair of session on Advances in BioProcessing.

The mission of a Toastmaster Club is to provide a mutually supportive and positive learning environment in which every member has the opportunity to develop communication and leadership skills, which in turn foster self-confidence and personal growth.Treasure tasks include keeping clear and accurate financial records of club business and for seeing that the club remains financially stable.

Lisboa, Pt

Leadership role in a non-profit organization which main objectives are to stimulate the development of strong relationships between the Portuguese postgraduate community living in North America and the American society while, simultaneously, promoting their home country.Accomplished tasks include strengthen connection among Chapter Leaders located throughout the US, Canada and Portugal and the organization of the XIV Annual Forum in Boston with the theme: “PAPS: Bringing Portugal to New Heights”. The forum was a space for sharing experiences and capitalizing on the value of its participants and guests (http://www.papsonline.org/forum2013/). Also included workshops on practical information, career coaching, public speaking and leadership skills, turning ideas into businesses or patent law!

Lisboa, Pt

Leadership role in a non-profit organization at a local level which main objectives are to stimulate the development of strong relationships between the Portuguese postgraduate community living in North America and the American society while, simultaneously, promoting their home country.Accomplishments include:- Creating the foundation of a strong and vibrant group in Washington DC, Baltimore and north-Virginia areas- Local encounters monthly- Strengthen relationship with the Portuguese Embassy in the US - Mingle with special Portuguese guest located in the area with the purpose to present our organization and improve the quality of our local networking- Build a local information package to support new and current members on their local lifestyle and publish it on-line

Baltimore, Md, Us

As an UMBC-CYA officer I have been helping young alumni stay connected to UMBC through organization of social events, volunteer opportunities, career networking connections, meaningful philanthropy and more.Among social events the highlights are off-Broadway shows and the Annual Wine tasting with silent auction.

Baltimore, Md, Us

Developed novel methodology for examining residue specific equilibrium unfolding constants of a disease related protein, Aβ. Equilibrium unfolding constants were used to quantify local differences in solvent accessibility of residues suspected to be important in cell association of peptide. MALDI-TOF and ESI-MS coupled with HPLC or LC, together with chemical modification were uses as tools to examine Aβ protein structure. Implemented kinetic analyses along with mathematical modeling and parameter estimation strategies to obtain quantitative results.Explored Aβ-cell membrane and identified key proteins involved in Aβ induced biological activity utlilizing FCS, confocal microscopy and FRET, supported by cell culture and immonocytochemistry assays. Demonstrated relationship between Aβ solvent accessible residues and biological response.

Baltimore, Md, Us

Assisted instructor in undergraduate level chemical engineering classes. Held office hours, lectured in recitation sections and graded homework. Designed and tested laboratory experiments for Unit Operations laboratory and trained new TAs in running laboratory experiments.Courses include: Heat and Mass Transfer, Chemical Engineering Analysis and Biochemical Engineering Laboratory.

New York, New York, Us

This was a summer intership in 2006. I was working in two departments: Natural Product Discovery and Analytical Chemistry.I though that taking 3 months off from my PhD research and gain experience working in a big Pharmaceutical Company was extremely important to understand the "World behind School" here in the USA.

Porto, Porto, Pt

Phd, Chemical & Biochemical Engineering

Chemical Engineering, Protein Purification

B.S., Chemical Engineering