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Scientific and strategic leader with demonstrated success developing and implementing organizational and drug discovery portfolio strategy; leading teams, departments, and leadership teams across indications and modalities; and searching for and evaluating business development and collaboration opportunities. Experience with all stages of drug discovery from screening and target validation to translational biomarkers and first in human trials, with a focus in Oncology and Neuroscience. Deep expertise in neurodegenerative diseases and protein homeostasis across multiple modalities including small molecules, biologics, PROTACs, etc. Passionate about expanding the drug discovery toolbox to help turn life-threatening diseases into manageable chronic conditions.
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Co-FounderStealth Mode BiotechSan Diego, Ca, Us -
Chief Scientific OfficerTeal Omics Apr 2024 - PresentCambridge, Massachusetts, UsMy role: shaped the scientific vision and strategy of the company, articulating long-term and short-term goals, developing the budget, leading and shaping computational and in vitro teams. Key partner in fundraising efforts. Identified, recruited, and onboarded key members of the Scientific Advisory Board. Developed and led the company’s drug discovery efforts, from indication selection and target ideation working toward IND.Company overview: leveraging machine learning tools to develop signatures for every organ based on proteomics from blood, and using aging-related changing in these signatures to identify novel targets for neurodegenerative diseases and immune-related diseases of aging. -
Strategic AdvisorBloom Science, Inc. Nov 2024 - PresentSan Diego, California, UsMy role: advising the company on plans for advancing drug discovery programs into preclinical studies in neurodegenerative diseases.Company overview: developing first-in-class, breakthrough therapeutics that target the gut-brain axis for the treatment of rare and complex neurological and metabolic disorders. -
Member, Scientific Advisory BoardAlleo Labs Mar 2024 - PresentSan Francisco, California, UsMy role: helping to provide scientific guidance to senior management; evaluating and advising on partnership and fundraising opportunities.Company overview: developing novel therapeutics for neurodegenerative diseases based on AI-driven insights about a previously untapped class of targets. -
Member, Board Of DirectorsAlzpath Inc. Oct 2023 - PresentMy role: helping to provide strategic direction to senior management; member of Audit Committee.Company overview: developing biomarkers and diagnostics for Alzheimer's disease and other neurodegenerative diseases. -
Vp Neuroscience And Translational ResearchRecursion Nov 2021 - Dec 2023Salt Lake City, Utah, UsMy role: leader of Internal Portfolio department which includes all discovery activities across therapeutic areas, with current focus in Oncology. Building and scaling Neuroscience drug discovery programs across indications; leading translational research and biomarker development across therapeutic areas.Company overview: harnessing the power of artificial intelligence and machine learning (AI/ML) to industrialize drug discovery across stages and therapeutic areas. -
Scientific Director, Discovery And Translational Research, Neuroscience TrcBristol Myers Squibb Apr 2021 - Nov 2021Lawrence Township, Nj, UsMy role: scientific leader for discovery efforts in external collaborations, and member of senior translational team responsible for biomarkers and clinical trial preparation across multiple programs, targets, and modalities -
Associate Director, Protein Homeostasis, Neuroscience Thematic Research CenterBristol Myers Squibb Nov 2019 - Apr 2021Lawrence Township, Nj, UsMy role: building protein homeostasis and PROTAC portfolio within Neuroscience Thematic Research Center by proposing, initiating, and managing internal drug discovery projects relevant to neurodegeneration and neuroinflammation. Recruiting and developing strong research team. Proposing and evaluating business development and collaboration opportunities, performing diligence. Initiating and managing academic collaborations; representing BMS in consortia and at international conferences.
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Protein Homeostasis Lead For NeuroscienceCelgene Jan 2016 - Nov 2019Summit, New Jersey, UsLeadership role in Celgene’s new Neuroscience & Imaging Thematic Center of Excellence (NI TCoE). Helped to develop Celgene’s strategy in neuroscience. Worked closely with leaders within Neuroscience and across Research & Early Development organization to identify key areas of focus. Building protein homeostasis and PROTAC portfolio within NI TCoE by proposing, initiating, and managing internal drug discovery projects relevant to neurodegeneration and neuroinflammation. Recruiting and developing strong research team. Proposing and evaluating business development and collaboration opportunities, performing diligence, attending JP Morgan each year. Initiating and managing academic collaborations; representing Celgene in consortia. -
ScientistCelgene Jun 2014 - Jan 2016Summit, New Jersey, UsWorked as a member of Discovery Biology team focused on the discovery of novel therapeutics for hematological cancers including Acute Myeloid Leukemia (AML) and Diffuse Large B-Cell Lymphoma (DLBCL). Collaborated with team members and colleagues in other departments to design assays for mechanism of action and target validation using molecular and cellular biology tools. Much of the work in this group has focused on the role of Celgene’s compounds in protein homeostasis and the induction of compound-mediated ubiquitination and degradation of novel substrates of the Cereblon E3 ligase complex.
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Postdoctoral Research AssociateThe Scripps Research Institute Dec 2009 - Jun 2014La Jolla, California, Us* Collaborated with internal and external colleagues on multiple projects.* Spearheaded capital equipment purchases and outsourcing of services. Managed relationships with vendors and CROs.* Developed novel biochemical assays.* Successfully recruited, mentored, and managed associates. -
Postdoctoral Research AssociateBrigham And Women'S Hospital Jun 2009 - Nov 2009Us
Irit Rappley Skills
Irit Rappley Education Details
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Harvard UniversityNeuroscience -
Massachusetts Institute Of TechnologyBrain And Cognitive Sciences; Linguistics
Frequently Asked Questions about Irit Rappley
What company does Irit Rappley work for?
Irit Rappley works for Stealth Mode Biotech
What is Irit Rappley's role at the current company?
Irit Rappley's current role is Co-Founder.
What is Irit Rappley's email address?
Irit Rappley's email address is ir****@****bms.com
What is Irit Rappley's direct phone number?
Irit Rappley's direct phone number is +190867*****
What schools did Irit Rappley attend?
Irit Rappley attended Harvard University, Massachusetts Institute Of Technology.
What skills is Irit Rappley known for?
Irit Rappley has skills like Biochemistry, Molecular Biology, Cell, Cell Biology, Cell Culture, Assay Development, Neuroscience, In Vitro, Confocal Microscopy, Western Blotting, Neurodegeneration, Fluorescence Microscopy.
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