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Irwin Hollander is listed as Vice President of Research and Development at Lauren Sciences LLC, based in Monsey, New York, United States. AeroLeads shows a work email signal at pfizer.com and a matched LinkedIn profile for Irwin Hollander.
Irwin Hollander previously worked as Seeking Principal Research Scientist position at Pharma/Biotech and Principal Research Scientist at Pfizer. Irwin Hollander holds Ph.D., Biochemistry from Massachusetts Institute Of Technology.
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Over twenty years experience in a lead position in oncology drug discovery programs on protein-drug conjugates and signal transduction inhibitors with expertise in protein purification, protein characterization, HPLC, cell culture and assay development. Additional experience in antibiotics, inflammation and allergy. Managed associates in both academic and industrial positions. Experienced in directing an individual laboratory as part of a multidisciplinary approach to long and short term goals. Presently in leadership position as vice-president of R & D of Lauren Sciences LLC developing drugs for brain diseases using its platform for crossing the blood-brain barrier.. Numerous patents on immunoconjugates resulting in leukemia drug Mylotarg. Developed patented method to prevent aggregation during and after conjugation. Involved in early work on irreversible inhibitors of Her family kinases resulting in EKB and HKI (neratinib) which are undergoing clinical testing. Developed technique to distinguish reversible from irreversible tight-binding inhibitors that led to the drugs presently in clinical testing. Recently was in a senior position in a PI3K inhibitor program from its conception to approved INDs for one oral and one i.v. drug. Expression, purification, stabilization, and homogeneous HTS assays for PI3K alpha and gamma were all developed within the group.Specialties: drug discoveryprotein purificationcell cultureprotein stabilityassay developmentdrug delivery
Listed skills include Drug Discovery, Cell Culture, Protein Purification, Hts, and 15 others.
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Us
Leading Research at Lauren Sciences- a biotech with patented technology to encapsulate drugs and deliver them across the blood brain barrier. Have received 2 grants from the Michael J Fox Foundation to develop a treatment for Parkinson's disease one from the Campbell Foundation for AIDS to develop a treatment for neuro-HIV and one from the ALS Association to develop a treatment for ALS.
New York, New York, Us
Research in the monoclonal antibody program, conjugating toxic drugs to anti-tumor MoAbs, fragments, and other targeting molecules. Served as the biochemistry portion of a team in establishing conjugation and purification conditions for the development of two conjugates as clinical leads, one of which was approved as Mylotarg. Helped develop new mass spec methodology for protein-drug conjugates. Most recently worked in signal transduction including PI3 kinase and Ras pathway, tyrosine, and serine kinase inhibitor programs. Member of team that developed EGFR kinase inhibitor EKB-569 which led to HKI-272 (neratinib) EGFR-Her-2 inhibitor, currently in clinical trials. Part of small team (led by Director Robert Mallon) that developed two PI3K inhibitors with INDs approved by the FDA in 2009. Responsibilities included fermentation of insect cells, purification, assay development, cell assays, and screening. Also evaluated compounds from mTor, IRAK4, and other programs for effects on PI3K enzymes.
Major areas of research were in allergy and rheumatoid arthritis. Worked on monoclonal IgE, a recombinant IL-4, glycosylation of IgG in rheumatoid arthritis, purification of natural saccharides, late phase of allergy factor from rats, and inhibitors of mast cell degranulation.
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Irwin Hollander works for Lauren Sciences LLC.
Irwin Hollander is listed as Vice President of Research and Development at Lauren Sciences LLC.
AeroLeads has found 1 work email signal at @pfizer.com for Irwin Hollander at Lauren Sciences LLC.
Irwin Hollander is based in Monsey, New York, United States while working with Lauren Sciences LLC.
Irwin Hollander has worked for Lauren Sciences Llc, Pharma/Biotech, Pfizer, Lederle, and Monsanto/G.D. Searle.
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Irwin Hollander holds Ph.D., Biochemistry from Massachusetts Institute Of Technology.
Irwin Hollander is listed with skills including Drug Discovery, Cell Culture, Protein Purification, Hts, Cell Based Assays, Biochemistry, Hplc, and Protein Chemistry.
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