Isaac E. Kaba Email & Phone Number

California, United States

• Teach (GSI) CHEM 3A (Organic Chemistry I : Chemical Structure and Reactivity)• Lecturer: MaryAnn Robak

• Photoaffinity labeling for target identification• Cancer and CNS drug discovery• Small-molecule hit-to-lead optimization

United States

• Honors thesis in medicinal chemistry• Thesis titled “Synthesis and Structure-Activity Relationships (SAR) of Novel Dual Mechanism EZH2/AR Inhibitors for Prostate Cancer”

• Selected for Yale University’s Biological and Biomedical Sciences (BBS) Next Generation Excellence Initiative Program• Performed remote multi-Omics analysis in human tumor samples, aimed at deepening understanding of the links between metabolism and cancer and identifying novel drug targets for cancer treatment

Cambridge, Massachusetts, United States

• Selected for the Summer of Science Internship Program at the Novartis Institutes for Biomedical Research (NIBR)• Developed an independent project in the Global Discovery Chemistry (GDC) Department. My project involved utilizing synthetic organic chemistry to improve droplet-based microfluidic platforms to screen DNA-encoded libraries against hard-to-drug therapeutic targets. • Performed organic synthesis and purification using ISCO Normal Phase Chromatography, Liquid Chromatography/Mass Spectrometry (LCMS), and High Performance Liquid Chromatography (HPLC).• Presented my research findings as a poster at the Novartis Poster Session

United States

• Awarded the 2023 Academic Year Research Program Fellowship for the proposal titled “Design and Synthesis of Novel Thieno-Pyrimidine Derivatives for Triple-Negative Breast Cancer”• Performed small-molecules organic synthesis, purification (Combiflash), and characterization (NMR); Assisted/shadowed graduate students with tumor cell line culture and Western blot protein analysisMentor: Prof. Amit Tiwari (Department of Pharmacology and Experimental Therapeutics)

United States

• Honors Project/Physiological Chemistry: “Ferroptosis and Lipids Oxidation”• Performed the synthesis and characterization (NMR) of novel small-molecule probes/matrix and proceeded with the detection of oxidized lipids by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF)• Mentors: Prof. Hermann von Grafenstein & Prof. Ghassan Abushaikha (Department of Medicinal and Biological Chemistry)

United States

• Awarded the 2022 Summer Undergraduate Research Fellowship for the proposal titled “Synthesis of Novel PI3Kα inhibitors for cancer therapy”• Performed synthesis, purification and characterization (NMR) of small molecule drug-like analogs• Mentor: Prof. Ghassan Abushaikha (Department of Medicinal and Biological Chemistry)

Kinshasa, Congo (Drc)

• Undergraduate Research/Apprenticeship: “Microscopic Features, Antioxidant and Antimicrobial Potencies of Congolese Cosmetopiea’ Medicinal Plants”• Performed phytochemical analysis, plants powder microscopy and DPPH and ABTS free radicals scavenging assays.

Doctor Of Philosophy - Phd, Chemistry

Advisors: Prof. Ziyang Zhang (Department of Chemistry) & Prof. Robert Saxton (Department of Molecular and Cell Biology)

Bs (Hons) In Pharmaceutical Sciences, Medicinal & Biological Chemistry, Gpa 4.0/4.0 (Summa Cum Laude)

• Graduated with College and Departmental Honors in Medicinal Chemistry • Thesis titled “Synthesis and SAR of Novel EZH2/AR Inhibitors.

As In Pharmaceutical Sciences, Distinction (First Class Honors)