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Ivan Tomasic is listed as Senior Associate Scientist at Bristol Myers Squibb based in San Francisco Bay Area, United States, United States. AeroLeads shows a matched LinkedIn profile for Ivan Tomasic.
Ivan Tomasic previously worked as Senior Associate Scientist at Bristol Myers Squibb and Senior Research Associate II at Myokardia. Ivan Tomasic holds Master Of Science - Ms, Biochemistry from University Of Massachusetts Amherst.
I bring over 15 years of experience in protein purification and characterization, assay development, small molecule drug discovery, compound characterization, and scientific collaborations in the biotech and pharmaceutical industry. My core experience lies on the biochemistry side of small molecule drug development, with a particular focus on the cardiac and ubiquitin-proteasome fields.
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Brisbane, California, United States
- Significant contributions to FDA filings, including MYK-461 (Mavacampten) NDA and MYK-491 (Danicamtiv) IND.- Conducted detailed mechanistic studies on MYK-491 using advanced biophysical techniques (Loaded In-Vitro Motility Assays, optical trap experiments), resolving its mode of action (MOA) compared to other compounds like Omecamtiv Mecarbil.-Led.
Brisbane, California, United States
-Served as the biochemistry/biophysics representative for the MYK-224 project from pre-candidate selection through regulatory filing. Conducted all IND-related biochemistry and biophysical characterization, including MOA studies, single turnover stopped-flow experiments, steady-state ATPase kinetics, IC50 determinations, multi-species potency tests.
South San Francisco, California, United States
- Developed a high-throughput In-Vitro Motility screening assay to identify lusitropic modulators of B-Cardiac Myosin for heart disease treatments.- Characterized the biophysical effects and MOA of 2-Deoxy-ATP (dATP) on the chemo-mechanical cycle of B-Cardiac myosin using stopped-flow experiments, steady-state ATPase assays, In-Vitro Motility assays, and.
Boston, Massachusetts, United States
- Built and optimized the site’s high-throughput screening (HTS) platform, including Envision plate readers, liquid handlers, and robotics.-Developed assays for pharmaceutical clients, including a TR-FRET parkin screen assay, and executed a 100K compound small molecule screen.-Investigated Mdm2 (E3 ligase)-mediated ubiquitination of p53 and led the.
Amherst, Massachusetts, United States
- Investigated lysosomal storage disorders (Fabry and Schindler diseases) to understand how mutations in α-GAL and α-NAGAL enzymes contribute to these conditions using various molecular and structural biology techniques.-Engineered point mutations in the α-GAL enzyme to develop a novel Enzyme Replacement Therapy for Fabry disease, aiming to avoid IgG.
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Ivan Tomasic is listed as Senior Associate Scientist at Bristol Myers Squibb.
Ivan Tomasic is based in San Francisco Bay Area, United States, United States.
Ivan Tomasic has worked for Bristol Myers Squibb, Myokardia, Boston Biochem, and University Of Massachusetts Amherst.
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Ivan Tomasic holds Master Of Science - Ms, Biochemistry from University Of Massachusetts Amherst.
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