Jennifer Beaudoin Email & Phone Number

Cambridge, MA, US

Cambridge, Massachusetts

Cambridge, Massachusetts

Cambridge, Massachusetts

Head Teaching Fellow for The Organic Chemistry of Drug Synthesis and ActionAssists students in understanding all course work and related topics, through in class discussions, office hours, and email. Provide students with detailed and thorough explanations to all questions, along with practice and guidance in writing synthetic schemes and reaction.

Cambridge, Massachusetts

Synthetic organic chemist developing novel materials and methods for the delivery of RNA into plants and insects.

Cambridge, Massachusetts

• Performed compound optimization for the development of novel antibacterials with broad-spectrum gram-negative activity.
• Designed, synthesized, and performed medicinal chemistry on multiple novel compound classes targeting P. falciparum.
• Optimized synthetic routes to enable preparation of hypothesis-driven derivatives via both solution and solid phase chemistry.
• Authorship on two patent applications for the treatment of malaria.
• Organized and mentored two interns to perform initial SAR investigation on a HTS lead for malaria through utilizing solid phase chemistry.
• Optimized in vitro screening to identify hit candidates for malaria with novel mechanisms of action.

Cambridge, Massachusetts

• Validated hits from HTS from diversity oriented synthesis (DOS) libraries, leading to hit to lead optimization on a novel compound class with pico-molar activity against P. falciparum in a live/dead blood stage malaria.
• Established SSAR (stereochemical, structure, activity, relationship) and improved physicochemical properties for increased performance in 3d7 and Dd2 P. falciparum strains, leading to in vivo testing.
• Contributed to the development of a molecular probe for the NIH Molecular Libraries Program, ML238.
• Performed large scale syntheses of key intermediates for initial and follow-up SAR.
• Designed and synthesized a small molecule solution phase combinatorial DOS library.
• Aided in the transferability of the library to the Automated Laboratory System at Eli Lilly.

Worcester, Massachusetts

Developed a novel peptide isostere via olefin cross metathesis to study the key hydrogen bond interactions between Vancomycin and its endogenous substrate.

B.A., Chemistry, Pre-Med

Activities and Societies: Women's Varsity Crew, Orchestra

Medicinal Chemistry

Completed the following graduate level courses: Biotechnology E-205: Drug Discovery, Project Design, and Management (Fall 2012) Chemistry.