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Medical Science Liaison supporting products in the following therapeutic areas:o Oncology (Hematology - B cell malignancies and AML; solid tumor - prostate, NSCLC, bladder, GI)o Rare neuromuscular and neurological diseaseso Autoinflammatory disorders and autoimmune disease o Metabolic and Genetic disorders20+ years of scientific experience, including medical affairs and drug discovery (including target discovery, assay development and small molecule development). Was a co-founder of CalciMedica, targeting the CRAC channel, a calcium channel, for the treatment of autoimmune disorders. Over 20 peer reviewed scientific publications and over 20 published poster presentations. AdditionalI experience in:o Immunology, inflammation, respiratory and autoimmune disease o Neuroscience, including basic mechanisms of synaptic transmission and drug and target discovery in the Alzheimer’s field o Pancreatic acinar cell biology, including cellular calcium imaging and basic endocrine function o Cell biological processes, including ion transport across the plasma membrane, intracellular membrane transport and post-translational modifications, such as protein glycosylationo Genetic methods of target identification
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Global Medical Affairs LeadAstrazeneca Nov 2020 - PresentCambridge, Cambridgeshire, Gb- Oversee and support the development and execution of an integrated medical plan in hematology, including evidence generation and confidence activities- Lead development and execution of global externally sponsored research and early access program strategies- Partner cross-functionally in the marketing countries, development, early research, regulatory, commercial, access, health outcomes and additional key functions to build alignment on key initiatives -
Executive Medical Science LiaisonAstrazeneca Aug 2020 - Nov 2020Cambridge, Cambridgeshire, GbField-Based Medical Affairs position supporting hematology- GenerationHeme Global Advisory Board - co-lead global community advisory board supporting Calquence for the treatment of CLL- Identifies KOLs and establishes on-going professional relationships, identifies investigators for participation in AstraZeneca clinical studies, ensures all KOLs on the speakers bureau are updated on new information as appropriate- Provides product research data and approved scientific information regarding AstraZeneca products and disease state management to thought-leaders, academic institutions, healthcare professionals, and professional organizations- Liaison for Investigator Initiated Trial submissions in line with company strategy in oncology that support scientific needs and supports presentation and/or publication plan- CLL tumor lead and Insights lead- Supports commercial and marketing stakeholders to lead brand strategy planning and support advisory boards
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Senior Medical Science LiaisonAstrazeneca Jun 2018 - Aug 2020Cambridge, Cambridgeshire, GbField-Based Medical Affairs position in hematology- Identifies KOLs and establishes on-going professional relationships, identifies investigators for participation in AstraZeneca clinical studies, ensures all KOLs on the speakers bureau are updated on new information as appropriate- Provides product research data and approved scientific information regarding AstraZeneca products and disease state management to thought-leaders, academic institutions, healthcare professionals, and professional organizations- Liaison for Investigator Initiated Trial submissions in line with company strategy in oncology that support scientific needs and supports presentation and/or publication plan
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Senior Medical Science LiaisonAstellas Pharma Jun 2016 - Jun 2018Doctorate Level, Field-Based Medical Affairs position supporting Xtandi for metastatic castration resistant prostate cancer, Tarceva for metastatic NSCLC and the development of Gilteritinib for FLT3-mutated AML- Identified KOLs and established and maintained on-going professional relationship, identified appropriate KOLs for participation in Astellas clinical studies, ensured KOLs on the speakers bureau are updated on new information as it arises- Provided product research data and approved scientific information with KOLs regarding Astellas products and disease state management to thought-leaders, academic institutions, healthcare professionals, and professional organizations- Facilitated Investigator Initiated Trial submissions in line with company strategy in oncology that support scientific needs and supports presentation and/or publication plan
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Senior Medical ScientistGilead Sciences Sep 2015 - Jun 2016Foster City, Ca, UsDoctorate-level, Field-Based Medical Affairs Position- Supported therapies targeting hematological, B-cell malignancies, including chronic lymphocytic leukemia (CLL), follicular lymphoma (FL) and small lymphocytic leukemia (SLL)- Provided clinical information about Gilead’s oncology products to thought-leaders, academic institutions, healthcare professionals, and professional organizations- Established and maintained on-going professional relationships with key institutions and oncology-focused academic societies and research consortiums- Identified appropriate investigators and facilitated the development of study proposals and/or placement into Gilead sponsored trials, including phase III/IV, outcomes research, pharmacoeconomic and database registry studies- Provided scientific support at advisory boards, regional educational programs, conferences and other external meetings- Collaborates with National Accounts Division and other business units to assess key accounts and develop and implement account management strategies for marketed products aligned with corporate clinical and business objectives- Collaborated with colleagues across other functional areas, including Clinical Research, Medical Communications, Sales and Marketing -
Rare Disease Clinical LiaisonCatalyst Pharmaceuticals Apr 2015 - Aug 2015Coral Gables, Florida, UsDoctorate-level, Field-Based, Medical Affairs Position- Supported therapies targeting rare neuromuscular and neurological diseases, including Lambert-Eaton Myasthenia Syndrome (LEMS) and Congenital Myasthenic Syndromes (CMS)- Established and maintained scientific relationships with KOLs- Provided education, recruitment, and assistance to clinicians regarding Catalyst’s Expanded Access Program ▸ Collaborated with the Clinical organization to enhance patient enrollment in Catalyst-sponsored clinical trials with site recommendations and maintaining contact with investigators participating in ongoing studies- Provided disease education to patient and healthcare providers- Provided clinical information in response to unsolicited questions (as appropriate) in academic, community, payor, and healthcare provider settings -
Medical Science LiaisonSobi/Biovitrum Apr 2014 - Apr 2015Stockholm, Stockholm County, SeDoctorate-level, Field-Based, Medical Affairs Position.- Developed and maintained professional relationships with opinion leaders, prominent academic & clinical investigators and leaders of medical/scientific organizations who were willing to assist in the clinical/scientific evaluation of Kineret, Kepivance and Orfadin. - Contributed to publication planning, the development of medical education material, and other projects as assigned. - Served as local scientific resource planning for communication of product information. - Played an integral role in planning symposia and other expert panels, as well as advisory boards. - Provided support for answering unsolicited off-label questions. -
Director, BiologyCalcimedica Apr 2007 - Apr 2014Co-founder (2007)- Involved in target discovery work that led to identification of CRAC channel (Roos et al 2005; Zhang et al 2006)Preparation and update of data packages and slide decks- Presentations for potential investors and corporate partnerships- Preparation and submission of SBIR grant (Aug 2013)- Selected talk at Gordon Research Conference on Calcium Signaling (2011)Member Drug Development IND team- 1st in human, 1st in class Phase 1A.B study in patients with moderate to severe psoriasisManage a team of 5 scientists (1 PhD immunologist, 4 Research associates)- Manage assays for drug development from compound registration to in vivo studies- Manage outsourcing of selectivity assays
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Principal ScientistTorreypines Therapeutics Nov 2000 - Mar 2007UsMember, Late Onset Alzheimer’s Disease (LOAD) Project Team- Developed biological validation efforts on genes identified with association to Alzheimer’s Disease by conducting gene-specific RNAi knockdown experiments.- Prepared quarterly reports to large pharmaceutical project partner. Presented data at Joint Steering Committee meetings.Member, Intracellular Calcium Dysregulation (ICD) Project Team- Developed and performed mammalian and Drosophila cell line RNAi and cDNA overexpression technology to screen for novel targets in store-operated calcium entry (SOCE).- Screened over 150 genes for candidate genes involved in store-operated calcium entry. Identified STIM1 as a key component in SOCE.
Jack Roos Skills
Jack Roos Education Details
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University Of California, San FranciscoBiophysics And Molecular Biology -
Stony Brook UniversityBiochemistry And Cell Biology
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Uc San DiegoMolecular And Cell Biology
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The University Of Texas At Austin
Frequently Asked Questions about Jack Roos
What company does Jack Roos work for?
Jack Roos works for Astrazeneca
What is Jack Roos's role at the current company?
Jack Roos's current role is Global Medical Affairs Lead at AstraZeneca.
What is Jack Roos's email address?
Jack Roos's email address is ja****@****ica.com
What is Jack Roos's direct phone number?
Jack Roos's direct phone number is +185895*****
What schools did Jack Roos attend?
Jack Roos attended University Of California, San Francisco, Stony Brook University, Uc San Diego, The University Of Texas At Austin.
What skills is Jack Roos known for?
Jack Roos has skills like Assay Development, Drug Discovery, Cell, Protein Chemistry, Cell Biology, Clinical Trials, Immunology, Oncology, In Vitro, Genetics, Purification, Neuroscience.
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