Jackson Barr Email & Phone Number

Santa Barbara, California, Us

21201, Md, Us

· Serve as primary study coordinator for a multicenter clinical trial investigating hyperbaricoxygen treatment for patients with severe traumatic brain injury; (https://siren.network/clinical-trials/hobit)· Serve as primary study coordinator for a multicenter clinical trial investigating the effectivenessof brain tissue oxygen optimization for monitoring and treating patients with severe traumaticbrain injury in the intensive care unit (https://siren.network/clinical-trials/boost-3)· Facilitated external IRB approval for exemption from informed consent (EFIC) for the aboveclinical trials· Included on the designation of authority log and actively worked on 13 interventional trials and25 observational studies during my tenure· Screen patients real-time for trial inclusion and exclusion criteria in the Trauma Resuscitationand Critical Care Resuscitation units, closely following differential diagnoses, imaging studies,and laboratory results of critically ill patients in order to determine trial eligibility within tightenrollment windows (e.g. 8 hours from injury to intervention)· Perform informed consent for enrollment into interventional and observational clinical trials withcritically ill patients and/or their family members. Patient population includes: severe traumaticbrain injury, multi-system trauma, sepsis, necrotizing soft tissue infection, devastating vascularinjury, and COVID-19· Exercise clinical knowledge and medical record proficiency to monitor subjects for adverseevents (AE) and serious adverse events (SAE); report AE’s and SAE’s, document protocolexceptions and deviations· Work with study monitors during monitoring visits to assure data accuracy, proper sourcedocumentation, and protocol adherence· Train new hires; trained over a dozen research assistants on numerous study protocols,often covering foundational knowledge of human anatomy and physiology, trauma and criticalcare medicine, and good clinical practice

21201, Md, Us

· Screened, recruited, and consented potential clinical trial candidates for over 14 ongoinginterventional and observational trials at the R Adams Cowley Shock Trauma Center at theUniversity of Maryland Medical Center· Consistently the top enrolling employee among research staff ac· Facilitated clinical trial interventions for intensive care patients, coordinating with multiplehospital services· Served as primary study coordinator for an observational trial validating a survey to assess therisk of developing post-traumatic stress disorder in trauma patients· Gathered data from electronic medical records (Epic and Cerner) for trial activities· Updated and maintained patient records on proprietary inpatient clinical charting software fortracking inpatient research subjects· Managed and completed study documentation, including but not limited to case report forms,source documentation, regulatory documents, signed informed consent forms, relevant IRBapprovals, drug dispensing logs, subject logs, screen-fail logs, and study related communications· Severed as liaison to primary study coordinators from other research departments forcollaborative projects· Collected, processed, stored, and shipped patient study samples such as blood, plasma, sputum,and cerebrospinal fluid· Promoted to Clinical Research Coordinator

21201, Md, Us

Contributed to multiple vaccine development projects primarily in the areas of antigen purification, bioconjugation, and assay development, primarily focusing on nosocomial infections· Presented data and worked to establish project goals and timelines in weekly lab meetings· Conducted extensive database research for the development and execution of laboratoryprotocols including fermentation, purification, and assay protocols· Operated a 14L SIP bioreactor, growing bacteria such as recombinant E. coli, SalmonellaEnteritidis, Pseudomonas aeruginosa, and Klebsiella pneumoniae· Verified identity and purity of bioprocessed antigens using a variety of techniques such ascolorimetric assays, SDS-PAGE, Western blotting, HPLC-SEC, and HPIC· Maintained extensive stock of bacterial antigens to accommodate growing development process· Prepared bioconjugates from bioprocessed material for mouse and rabbit immunization

· Performed the following work as part of a Bill and Melinda Gates Foundation Typhoid feversurveillance project in collaboration with the University of Maryland School of Medicine’sCenter for Vaccine Development, producing the antigen essential for the ELISA element of thework· Operated a 5L bioreactor growing Citrobacter freundii WR7011· Isolated Vi (Salmonella Typhi capsular polysaccharide) from fermentation cultures using avariety of purification techniques, including precipitation and filtration· Verified identity and purity of bioprocessed materials using a variety of techniques, includingHPAEC-PAD, functional group assays, ELISA, and BCA protein assays· Developed and wrote fermentation and assay protocols; conducted extensive database researchfor protocol development

21201, Md, Us

· Contributed significantly to multiple vaccine development projects for bacterial pathogens· Operated a 14L SIP bioreactor, growing recombinant E. coli, Salmoella Enteritidis,Pseudomonas aeruginosa, and Klebsiella pneumoniae· Isolated flagellin proteins, O-specific polysaccharides, and capsular polysaccharides fromfermentation cultures using a variety of purification techniques, including precipitation,tangential flow filtration, membrane chromatography, anion exchange chromatography, andsize-exclusion chromatography· Verified identity and purity of bioprocessed antigens using a variety of techniques such asSDS-PAGE, western blotting, HPLC-SEC, and HPIC· Developed and wrote fermentation and assay protocols

Rockville, Maryland, Us

· Conducted molecular cloning of a genetic reporter system for a novel anti-cancer virus at a smallbiotechnology start-up· Cultured bacteria, performed plasmid DNA mini preparation, performed PCR amplification ofDNA, modified plasmid DNA with restriction enzymes, performed electroporation of bacteriafor plasmid DNA uptake· Assisted in the maintenance of the laboratory, including operating an autoclave to sterilizeequipment, cleaning glassware, and re-stocking lab benches weekly to support project workflow

Annandale-On-Hudson, Ny, Us

· Tutored biology students on longform writing assignments such as literature reviews, projectproposals, and laboratory reports

Annandale-On-Hudson, Ny, Us

· Examined hair cell regeneration in the lateral line neuromasts of larval zebrafish usingimmunostaining and fluorescence microscopy· Performed regular care and maintenance of zebrafish, including regular mating to maintain stockof larvae· Conducted molecular cloning of a zebrafish gene

· Independently developed a novel conjugation protocol with improved efficiency; this protocolwent on to be used by an Indian vaccine manufacturer to produce licensed conjugate vaccines· Conducted and analyzed experiments to determine the stability and reaction characteristics of areagent used for protein-polysaccharide bioconjugation· FPLC-SEC for the purification of bioconjugates· HPLC-SEC and colorimetric assay analysis of bioconjugates

· Synthesized functionalized polysaccharides and characterized reaction products usingcolorimetric assays and HPLC-SEC analysis· Developed an HPLC-SEC analysis protocol· Synthesized protein-polysaccharide bioconjugates· Purified bioconjugates using tangential flow filtration and size exclusion chromatography