Jacob Lang Email & Phone Number

United States

Emeryville, California, United States

- Developing mammalian cell-culture and microbial processes for production of monoclonal antibodies, antigens, and enzyme products- Managing up to 5 scientists and specialists during bioreactor studies - Acting as Upstream Project Lead, representing group in multi-department project coordination meetings- Created novel upstream fermentation process for production of recombinant enzyme in E. coli, resulting in 900% increase in titer- Developed upstream process for new yeast cell line, resulting in 500% increase in titer- Created 2L scale-down model of 4,000 L yeast manufacturing process- Oversaw successful tech transfer run of external 4,000 L yeast fermentation process to pilot plant- Utilized AMBR250 system to optimize and scale-up cell culture mAb production process- Implementing various techniques for post-production processing, including: floor centrifugation, disk-stack centrifugation, bead-millling, microfluidizing, tangential-flow filtration (TFF), and ultrafiltration/diafiltration (UF/DF)- Authoring experiment designs and batch production documents (BPDs), and creating run schedules- Reviewing primary academic and industry literature sources to improve process development - Analyzing experiment data, writing project reports, and presenting findings to department- Training team members on experimental procedures- Implemented multiple laboratory changes to increase efficiency and decrease cost of bioreactor runs- Reviewing documents authored by team members- Writing SOPs for new equipment and lab procedures- Coordinating with vendors to onboard new analyzers and equipment

South San Francisco, California, United States

Davis Ca

- Oversaw team responsible for experiment design and data analysis for the development and validation of a novel pH monitoring system- Interviewed and recruited scientific & product development team- Establishing company framework for mammalian cell culture bioreactor runs- Raised $60,000, including $30,000 from NSF, with CEO for early-stage research and client discovery- Participated in NSF National I-Corps program- Conducted customer discovery interviews- Providing insight into biomanufacturing processes and real-world industrial scenarios in order to aid in the continual improvement of system

- Coordinated and participated in design and execution of process development, optimization, troubleshooting, and validation studies supporting large-scale biomanufacturing operations - Performed laboratory operations, including: media and bioreactor preparation, reagent inventory, maintenance of analytical equipment, monitoring of CHO cell culture health and performance, harvesting of antibody product, and review and analysis of study data- Trained manufacturing technical specialists on laboratory operations- Collaborated with engineers for project debugging and implementation- Consulted with subject matter experts to determine urgent needs in process improvement- Created and implemented data transfer process to facilitate rapid deployment of a next-generation cell culture process analytical technology

Davis, Ca

- Directed an undergraduate-run research organization focused on exploring applications of biotechnology- Ran bi-weekly meetings with Board of Directors for strategic planning and organizational problem-solving- Hosted quarterly Research Project Showcase- Interacted with industry executives to develop framework for company-sponsored research projects- Evaluated hundreds of candidates for roles in various different areas, including research, laboratory management, and project management- Collaborated with professors, peers, and university leadership to develop, implement, and improve new initiatives, including:- - - Biotech Entrepreneurship Program- - - Student Laboratory Manager Program- - - Molecular Biology Skills Training- - - Scientific Leadership Internship Program- - - Biotech Career Club- - - Weekly Journal Club (for scientific papers)

Davis, Ca

- Acted as scientific and managerial adviser to multiple project groups- Established new research projects in collaboration with scientific leads- Expanded the network of biotechnological entrepreneurship among undergraduates- Spearheaded the creation of a mammalian synthetic biology program- Taught new researchers how to utilize research papers in experimental troubleshooting

Davis, California

- Oversaw the adherence to general safety procedures- Administered safety training to laboratory workers- Prepared materials for molecular biology-based laboratory course- Trained individuals on basic molecular biology techniques such as pipetting, PCR, gel electrophoresis, cell culturing, etc.- Assisted project groups with both procedural knowledge and background information pertinent to their work

Davis, California

- Created a biosensor to detect the physiological stress caused to mammalian cells from environmental toxins- Created SOPs for cloning, mammalian cell culturing, transfection & fluorescent microscopy- Examined primary literature to find regulatory sequences from mammals, including humans, mice, and Chinese hamsters-Produced multiple promoter-reporter systems, using restriction enzyme and SLIC cloning, to express Green Fluorescent Protein (GFP) when induced by toxins- Cultured and transfected CHO & AML (murine hepatocyte) cell lines- Measured expression rates using multi-well plate reader and fluorescence microscopy