Jacob Mcphail Email & Phone Number

San Francisco, CA, US

San Francisco, California, United States

I am engaged in fundamental research to understand the process of protein misfolding in neurodegenerative diseases as well as translational research to apply this knowledge toward drug discovery assays. As part of a multidisciplinary team at the UCSF Institute for Neurodegenerative Diseases, I work to discover small molecule drugs that prevent the.

Victoria, British Columbia, Canada

I led the R&D division of StressMarq Biosciences in studying the abnormal aggregation of key prions that drive neurodegenerative diseases. My team developed numerous alpha-synuclein, tau and amyloid beta mutants, including conjugates, oligomers, and fibrils as commercial reagents (within ISO 9001:2015 standards) for use in Alzheimer's and Parkinson's.

Victoria, BC, CAN

Under the mentorship of Dr. John Burke, I studied the lipid kinase PI4KB to elucidate its key roles in the replication of several prominent human pathogens, including RNA viruses, malaria and cryptosporidium. I utilized numerous structural and biophysical techniques, including x-ray crystallography and hydrogen-deuterium exchange mass spectrometry.

International

As part of an international collaboration focusing on drug development against the malaria parasite, I screened novel anti-malarial compounds for inhibition of a malaria kinase (PI4K) using lipid kinase activity assays on biochemically reconstituted membranes in the Dr. John Burke Laboratory.

Canada

I developed and instructed online final exam prep courses for 1st year Biology at UVic (BIOL184 and BIOL186) for over 1000+ students.

Victoria, BC, CAN

I developed and instructed in-person final exam prep courses for 1st year Biology at UVic (BIOL184 and BIOL186) for class sizes ranging from 70-200+ students.

Laboratory For Foodborne Zoonoses - Lethbridge, AB, CAN

I cloned, expressed and purified a Shiga toxin mutant from enterohemorrhagic E.coli 0157:H7 for utilization as a safe, non-toxic antigen for immunological experiments.

Centre For Plant Health - Sidney, BC, CAN

I screened Canadian crops for infection with Plum Pox virus using ELISA and RT-qPCR, and also studied virions using transmission electron microscopy (TEM).

National Microbiology Laboratory - Winnipeg, MB, CAN

I optimized the plaque reduction neutralization test (PRNT) for measles virus for use in a national measles immunity survey.

Doctor Of Philosophy - Phd, Biochemistry

Dissertation: Molecular Mechanisms of Phosphatidylinositol 4-kinase III beta (PI4KB) regulation and their role in human disease. My.

Bachelor Of Science (Honours) With Co-Op, Microbiology

Honours Thesis: Specific inhibition of Plasmodium phosphatidylinositol-4-kinase and characterization of its interface with Rab11a. Co-op.