Jacob Smith Email & Phone Number

United States

Preparing patent applications covering innovations protecting small molecule therapeutics.Crafting arguments to office actions to prosecute high value patent applications.Managing electronic databases, coordinating extensively with internal team members, to document small molecule portfolios.Interfacing with intellectual property and medicinal chemistry discovery groups to understand the value and innovation of inventive space surrounding small molecule therapeutics.Evaluating prior art and 3rd party inventions to assess patentability and freedom-to-operate (FTO) landscapes.Structurally characterizing novel small molecules through the analysis of data from NMR spectroscopy experiments and mass spectrometry.

Rockville, Maryland, United States

Synthesized new classes of small molecule-linker payload modalities for the development of antibody-drug conjugate (ADC) anti-cancer therapeutics within a preclinical research and development setting.Supervised the workflow of an internal team of synthetic chemists to timely achieve platform development goals.Coordinated platform development with cross-functional teams (biologists, protein engineers) along with contract research organizations (CROs).Presented progress to C-suite executives and research leaders on a weekly basis.Performed FTO and patent analysis of competitor products, identifying viable chemical space within which to pursue clinical targets.Developed methodologies and NMR capabilities to enable structural elucidation of target molecules, as well as evaluate chemical characteristics associated with pharmacokinetic properties through NMR experiments.

Washington Dc

Led due diligence efforts in transactional matters for life science companies, preparing summaries that evaluate the strength of IP portfolios and identifying freedom-to-operate issues.Served in a client-facing role, working with companies to assess innovations across a wide variety of scientific and engineering disciplines.Utilized public and proprietary patent databases, evaluating patent families and prosecution histories, prior art, chain-of-title, of US and ex-US patents of interest.

Ashburn, Virginia, United States

Spearheaded the synthesis of novel organometallic and fluorescent molecules for microscopy imaging experiments.Collaborated with a diverse array of scientists (biologists, physicists) on a routine basis to pursue high impact projects.

Charlottesville, Virginia, United States

Led research projects to investigate the ability of transition metals to enable novel organic reactivity, generating small molecules for drug leads and studying dynamic behavior of organometallic systems.Spearheaded research endeavors leading to 10 co-authored high impact publications (e.g. Nature, Nat. Comm, Sci. Adv.), a US patent application (17/619,827), funded grants from the NSF and NIH (> $ 2.2 million granted) and new collaborations at UVA, and with Brigham Young University and the Oak Ridge National Laboratory. Mentored undergraduate and early stage graduate students.

Charlottesville, Virginia, United States

Worked in collaboration with the Biomolecular Magnetic Resonance Facilities Director, Jeff Ellena, Ph.D. to maintain Bruker and Varian NMR instrumentation. Maintained NMR instrumentation with routine temperature calibration, cryogenic gas refills and troubleshooting instrumentation issues when they arose; trained new students on proper NMR protocols.

Detroit, Michigan, United States

Determined chemical composition for materials used in steel production via practices in accordance with the American Society for Testing and Standards (ASTM). Oversaw a chemical technician while maintaining and working with a wet lab, ensuring maintenance of various instruments and apparatuses (IR, GC-MS, titrators, spectrometers, furnaces).Documented plant critical processes and prepared daily reports of chemical composition an by-products to upper management.

Lansing, Michigan, United States

Oversaw product development via assays, UV-vis spectroscopy and various wet chemistry tests. Formulated buffers and compounds for product development and testing.Analyzed data as it applied to quality-controlled products, ensuring good manufacturing practices (GMPS) were met.

Doctor Of Philosophy - Phd, Chemistry

Bachelor Of Science - Bs, Chemistry

Activities and Societies: Varsity Wrestling Team (NCAA Division III), Captain Senior Year