Jacob Cheong Email & Phone Number

Singapore

Singapore

Singapore

• Final Year Project (FYP) in fulfilment of a Bachelor of Science (Honours) Degree in Chemistry with Specialisation in Medicinal Chemistry. Conducted research under the supervision of A/P Chng Shu Sin and Dr. Chong Zhi.
• Performed molecular cloning of His-tagged POIs for pull-down assays.
• Performed Spot Plate assays to verify phenotypic rescue of His-tagged complements in knockout mutants.
• Performed protein extraction and pull-down assays using IMAC. Identified several novel interactions between interacting partners and one of the POIs as a result of the pull-down assays.
• Regularly performed Gel Electrophoresis, Staining & Immunoblotting.
• Conducted in vivo photoaffinity crosslinking experiments using unnatural amino acids genetically incorporated into the POIs via Site-Directed Mutagenesis.

Singapore

• Conducted research under the supervision of Dr. David Quach in fulfilment of a requirement for the A*STAR Undergraduate Scholarship (AUS) at the Experimental Drug Development Centre (EDDC).
• Synthesised, purified and characterised a small drug library of Proteolysis-Targeting Chimeras (PROTACs) for the treatment of various cancers.

Singapore

• Served National Service (NS) and held the rank of 3rd Sergeant. Held the appointment of ADWS at the 3rd Divisional Air Defence Artillery Battalion.
• Overall Systems IC responsible for ensuring the operational readiness of the Portable Search and Target Acquisition Radar (PSTAR) and Mobile PSTAR (MPSTAR) systems.
• Performed routine maintenance of the PSTAR & MPSTAR systems, scheduled the systems for planned maintenance to ensure operational readiness, and ensured maintenance and deployment records were duly handled.
• Worked in a highly teamwork-oriented environment, often communicating with other ICs to ensure tools, vehicles, signal sets, arms, and field equipment were prepared for operations.
• Instructed the incoming cohort of ADWS PSTAR/MPSTAR as an on-ground instructor.
• Participated in the RSAF Airshow 2018 for the exhibition of the MPSTAR system.

Singapore, Singapore

• Final Year Project (FYP) in fulfilment of a Diploma in Applied Chemistry and Pharmaceutical Science (Medicinal Chemistry Option). Conducted research alongside two other group members – Ethan Lim and Ben Ho – under the.
• Studied the crystallisation properties of Disodium Cromoglycate (DSCG) with the aim of altering crystal habit and increasing particle size through process optimisation, thereby improving manufacturing processes.
• Performed solvent screening to determine an appropriate solvent system and slurry experiments to investigate the effects of solvent composition on crystal habit and size.
• Measured solubility separately via conductivity, Crystalline instrument, and observation to establish the metastable zone width.
• Conducted cooling crystallisation growth experiments to study the effects of seed loading, cooling rate, and addition of anti-solvent on crystal habit and particle size.
• Characterised the DSCG crystals obtained in the experiments via Thermogravimetric Analysis (TGA), X-Ray Diffraction (XRD) and Microscope Imaging.

South West, Singapore

• Conducted research under the supervision of then-PhD student Nunnarpas Yongvongsoontorn in Dr. Motoichi Kurisawa's lab at the Institute of Bioengineering & Nanotechnology (IBN), Nanomedicine Department, as part of the.
• Prepared green tea-based micellar nanocomplexes (MNCs) for targeted drug delivery in cancer therapy via solid dispersion and purified them via dialysis.
• Studied the effect of varying polymer-to-drug ratio on the particle size, polydispersity, surface charge and drug loading of MNCs. MNCs were characterised via dynamic light scattering and UV/Vis spectroscopy.
• Tested the stability of the MNCs in various conditions.
• Performed in vitro cell viability assays and analysed in vivo data for the MNCs' antiangiogenic and antitumor effects.

Norwich, England, United Kingdom

• Conducted research under the supervision of then-PhD student Remy Narozny in Professor A. Ganesan's lab at the School of Pharmacy, University of East Anglia, as part of an Overseas Industrial Training Programme.
• Synthesised, purified and characterised drug analogues for the treatment of Schistosomiasis, a Neglected Tropical Disease.

Bachelor Of Science (Honours), Chemistry And Life Sciences, Ccap: 4.41/5.00 (Upper Second-Class Honours)

Primary Major: Chemistry (Specialisation in Medicinal Chemistry) Second Major: Life Sciences

Diploma, Applied Chemistry With Pharmaceutical Science, Cgpa: 3.883/4.000

Awarded a Diploma (with Merit) Specialisation in Medicinal Chemistry Director’s Roll of Honour in AY2015/16 and AY2013/14 Relevant Modules.