Jaime H. Cheah Email & Phone Number

Cambridge, Massachusetts, United States

500 Main Street, Cambridge, MA 02139

• Direct an open-access training facility.
• Conduct assay development and screen design,
• Work directly with researchers, training them to use the equipment, to understand the process at each step, to conduct screens, and to provide key input into data collation and interpretation.
• Function as a central repository for both small molecule collections and cell line collections donated by and for the MIT community.

Cambridge, MA

• In collaboration with the Center for the Science of Therapeutics’ Platform, led a team of biologists in profiling ~900 genetically characterized human cancer cell lines against a panel of 480 small molecule probes.
• Work closely with the Computational Biology group to perform quality control and enrichment analysis of the data to yield correlations of genetic features of the cancer cell lines to small molecule sensitivity or.
• Lead a small team of biologists in studying the correlation of cancer cell lines harboring mutations in beta-catenin and their sensitivity to the Bcl2-family antagonist, navitoclax.
• Interact with medicinal and synthetic chemists to generate novel compounds and tests them in cell-based assays.
• Mentor Research Associates, post-doctoral fellow, graduate and undergraduate students.

Cambridge, MA

• High-throughput profiling of 242 genetically characterized human cancer cell lines across a variety of lineages against a panel of ~300 curated compounds and measured cell viability in 384-well format; extensive tissue.
• Established and maintained high standards for robust data generation, implementing stringent checkpoints; designated as the “go-to” person for technical inquiries regarding data collection and exchange of resources.
• Managed and organized duties for a Biology team consisting of two Research Scientists, a Visiting Scientist, a Research Technician, a graduate student, a post-doctoral fellow and an undergraduate research assistant.
• Worked closely with a high level of communication with members of the Computational Biology team to create tools and perform QC and data analysis, generating hypotheses on genetic features of cancer cell lines.
• Liaison for the Chemical Biology Program and coordinating with the Chemical Biology Platform on the production phase of cell line profiling (~900 human cancer cell lines against ~500 compounds); gaining technical.

Cambridge, MA

- Running medium throughput screening assays.

Cambridge, MA

• Post-doctoral fellow in the Developmental and Molecular Pathway group, collaborating with the Cardiovascular and Metabolism group on advancing a TrkB agonist antibody towards submission for FDA approval.
• In vitro, in vivo and ex vivo characterization and validation of a novel TrkB receptor antibody agonist, which targets a cell surface receptor involved in neuronal differentiation and survival.
• Developed and optimized a capture ELISA assay to measure ex vivo antibody penetration into various tissues; conducted ex vivo analysis of pharmacodynamic markers to examine downstream biochemical changes in various.
• Collaborated with the Global Imaging Group (GIG) and coordinated efforts on various studies to define site and mode of action using a fluorescently labeled antibody.
• Conducted experiments examining the efficacy of the antibody in MeCP2 knockout mice, a mouse model for Rett Syndrome.
• Represented DMP on cross-functional drug discovery project teams in a deadline and goal-oriented environment; extensively participated in project team meetings and presented project updates to management and project.

Baltimore, MD

• Graduate Student in the Biological Chemistry, Cellular and Molecular Biology Program (BCMB) working in the laboratory of Dr. Solomon H. Snyder in the Department of Neuroscience. Studied neurotransmission and iron.
• Characterized a novel G-protein called Dexras1 and determined a novel binding partner via yeast-two-hybrid techniques.
• Showed that Dexras1 binds to an iron uptake channel and regulates iron uptake the brain, using various cellular and biochemical techniques, including co-immunoprecipitation, Western blotting, immunofluorescence.
• In vivo expertise using transgenic mice, including genotyping, intraperitoneal (i.p.) dosing and dissection.
• Extensively mentored numerous high school, college and graduate students.

Ph.D., Neuroscience

Activities and Societies: Active member of the Graduate Student Association (GSA); Senior Editor of the monthly GSA newsletter, The.

B.Sc, Biochemistry

Thesis: “Crystallization and structural determination of L-amino acid Oxidase by X-ray crystallography” Advisor: Dr. Alice Vrielink.

Education record