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James Dunce is a Co-Founder at Kinva Bio. He possess expertise in biochemistry, protein purification, protein expression, protein chemistry, hplc and 8 more skills.
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Co-FounderKinva BioUnited Kingdom -
Chief Executive OfficerBravelycultured Dec 2022 - PresentCambridge, England, United KingdomLeveraging marine microorganisms for sustainable production. -
Herchel Smith Postdoctoral FellowUniversity Of Cambridge Aug 2021 - Aug 2024Cambridge, England, United KingdomI am combining genetic manipulation of trypanosomes with super-resolution microscopy to track the movements of surface receptors with the aim of determining how nutrients are acquired without raising an immune response. Trypanosomes are parasites which infect mammals and cause sleeping sickness. They acquire nutrients from our blood using specialised receptor molecules on their surface. These receptors should elicit an immune response in our bodies leading to clearance of the infection but this does not happen. I am trying to figure out why. -
Postdoctoral ResearcherUniversity Of Cambridge Feb 2020 - Aug 2024Cambridge, England, United KingdomI spent a year developing methods aimed towards tracking the movement of single molecules on the surface of trypanosomes.
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Cohort 4Carbon13 Sep 2022 - Jan 2023Cambridge, England, United KingdomBravelyCultured was founded through the Carbon13 accelerator program. -
PhdNewcastle University Nov 2014 - Mar 2020Newcastle Upon Tyne, England, United KingdomDuring the production of gametes, homologous chromosomes are paired by a protein structure known as the synaptonemal complex. I used X-ray crystallography alongside biochemical and biophysical techniques to solve the structure of components of this structure and elucidate their roles on chromosome organisation. -
Summer Research StudentNewcastle University; Northern Institute For Cancer Research Jul 2014 - Aug 2014Newcastle Upon Tyne, United KingdomDrug Discovery and Imaging Group. Supervisor: Prof. Jane Endicott. I contributed to the studies directed towards defining the structural differences between the catalytic site of cyclin-dependent-kinases 1 and 2 by co-crystallising each kinase in complex with a panel of 8 known inhibitors. In this, I gained further experience in protein expression and purification utilising affinity chromatography with gravity flow and size exclusion chromatography using an ÄKTA-based system and UNICORN software. I was further involved in the crystallisation process including the preparation of crystallisation plates using the high-throughput liquid handlers BIOMEK and Mosquito. I also received an introduction to (including some practise of) crystal selection and cryo-protection. Finally, I gained experience performing circular dichroism and fluorescence spectroscopy to probe the secondary structure of Cks2.
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Undergraduate StudentNewcastle University; Northern Institute For Cancer Research Jan 2014 - Mar 2014Newcastle Upon Tyne, United KingdomClinical and Translational Group. Supervisor: Prof. Alan BoddyI utilised various in vitro assays and high-performance liquid chromatography (HPLC) to characterise the differences between the metabolism of the anticancer pro-drug Phortress (NSC 710305) into its active metabolite 5F 203 (NSC 703786) in both the red blood cell fraction and plasma of both mice and humans. This involved inhibition assays using a panel of 3 known non-specific hydrolase inhibitors and I further suggested and executed a plasma protein binding assay. I carried out data and statistical analysis using a combination of Empower, Prism 3.0 and MSExcel software.
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Summer Research StudentNewcastle University; Institute For Cell And Molecular Biosciences Jun 2013 - Sep 2013Newcastle Upon Tyne, United KingdomSupervisor: Prof. Bernard ConnollyWhile studying the effect of targeted mutations in archaeal polymerases (Pyrococcus furiosus and Thermococcus kodakarensis) with regard to the enzymes ability to extend and/or degrade a primer-template, I gained first-hand experience in the processes of: - site-directed mutagenesis by QuikChange PCR, - competent cell transformation and antibiotic selection, - bacterial culture and the induction of protein expression, - affinity chromatography with gravity flow, - in vitro biochemical assays (primer-template extension/exonuclease assays) - electrophoresis - and an understanding of EMSA by shadowing.
James Dunce Skills
James Dunce Education Details
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First-Class Honours
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Whitley Bay HighBiology, Chemistry, Physics, Mathematics -
Marden High SchoolGcses
Frequently Asked Questions about James Dunce
What company does James Dunce work for?
James Dunce works for Kinva Bio
What is James Dunce's role at the current company?
James Dunce's current role is Co-Founder.
What is James Dunce's email address?
James Dunce's email address is ja****@****l.ac.uk
What schools did James Dunce attend?
James Dunce attended Newcastle University, Whitley Bay High, Marden High School.
What are some of James Dunce's interests?
James Dunce has interest in Antisensescienceblog, Cycling, Wordpress, Com, Http, Running, Swimming, Scientific Blogging.
What skills is James Dunce known for?
James Dunce has skills like Biochemistry, Protein Purification, Protein Expression, Protein Chemistry, Hplc, Site Directed Mutagenesis, Crystallography, Affinity Chromatography, Size Exclusion, Bacterial Culture, Bacterial Transformation, Gel Electrophoresis.
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