James Flewellen Email & Phone Number

London, Gb

Developing a spinout company based around a novel biosensor technology.We have developed a novel bioelectronic interface technology that leverages the exquisite sensing capabilities of microorganisms to detect trace chemicals in liquid environments, and couples this to a custom integrated circuit to produce an electronic output. My role is partly technical: bringing to life a prototype device by overseeing integration of microbiology, electronics, liquid handling and surface chemistry, as well as leading on device design and some specific bioengineering aspects. And partly business development: identifying product-market fit, beachhead markets, angel customers; securing funding for technology and business development; and building a team around me to form a company to take this university innovation into the world.I have raised >£330k in grant funding for commercialisation activities so far, through Innovate UK ICURe Programmes, Scottish Enterprise, IBioIC and Edinburgh Venture Builder Incubator.

London, United Kingdom

Creator of a new way to learn about wine via my innovative visual wine guides. This is a unique project combining high quality data on wine regions with a beautiful designed aesthetic. "Everything you need to know about a wine region on a single piece of paper." They are perfect for wine students and wine lovers seeking to further understand their wine knowledge.I am also an award-winning author (for the original edition of "The Concise Guide to Wine and Blind Tasting"​ which won the Gourmand Award for Best Drinks Education Book (UK)) and have over 10 years experience teaching and communicating about wine.My introduction to wine came through competitive blind tasting, and I competed in – and won – numerous university wine tasting competitions – both domestically in the UK and internationally. I hold the WSET Level 4 Diploma in Wine and Spirits and am a judge for the International Wine Challenge based in London.I also run wine tastings in the UK and further afield and You can find out more at www.jamesflewellen.com.

London, England, United Kingdom

During this role, I developed a novel microscopy system for single-molecule force spectroscopy. This was achieved through integrating magnetic tweezers with digital holographic microscopy for 3D imaging of microscopic objects. I designed the experimental apparatus, wrote a 3D holographic image analysis software suite, and conducted force spectroscopy experiments of a range of protein-protein interactions.The aim of the project was to explore the biomechanics of B lymphocyte interaction with HIV envelope proteins under applied load, which better represents the physiological situation. However, the techniques I developed are applicable to a wide range of antibody-antigen and other protein-protein interactions.I worked at the interface of biophysics and immunology in this role in the laboratory of Pavel Tolar. The laboratory was based in the Francis Crick Institute, although I was initially employed by Imperial College London, until the adminstration of the funding grant was transferred to University College London in 2020.

London, United Kingdom

I worked at the interface of biophysics and immunology in this role in the laboratory of Pavel Tolar.My laboratory was based at the Francis Crick Institute; however I was employed first by Imperial College London and then University College London when the administration of the funding grant was moved.During this role, I developed a novel microscopy system for single-molecule force spectroscopy. This was achieved through integrating magnetic tweezers with digital holographic microscopy for 3D imaging of microscopic objects. I designed the experimental apparatus, wrote a 3D holographic image analysis software suite, and conducted force spectroscopy experiments of a range of protein-protein interactions.The aim of the project was to explore the biomechanics of B lymphocyte interaction with HIV envelope proteins under applied load, which better represents the physiological situation. However, the techniques I developed are applicable to a wide range of antibody-antigen and other protein-protein interactions.I also co-founded and ran the Single-Molecule Network – a network of London-based multidisciplinary scientists working at the cutting edge of single-molecule research. I helped establish this network and set up a series of half-day conferences at the Crick Institute to bring together single-molecule researchers working on disparate problems in the biomedical space.

London, United Kingdom

During this role, I developed a novel microscopy system for single-molecule force spectroscopy. This was achieved through integrating magnetic tweezers with digital holographic microscopy for 3D imaging of microscopic objects. I designed the experimental apparatus, wrote a 3D holographic image analysis software suite, and conducted force spectroscopy experiments of a range of protein-protein interactions.The aim of the project was to explore the biomechanics of B lymphocyte interaction with HIV envelope proteins under applied load, which better represents the physiological situation. However, the techniques I developed are applicable to a wide range of antibody-antigen and other protein-protein interactions.I worked at the interface of biophysics and immunology in this role in the laboratory of Pavel Tolar. The laboratory was based in the Francis Crick Institute, although I was employed by Imperial College London, until the adminstration of the funding grant was transferred to University College London in 2020.

Oxford, United Kingdom

Emerging from my academic research at Oxford University, Speckle Technologies was created to develop a mobile medical diagnostics platform. Speckle combines 3D imaging techniques with machine learning algorithms to produce optical diagnostics routines that are fast, efficient and cheaper than conventional laboratory-based techniques. Application areas include: medical diagnostics, veterinary science, food and beverage quality assurance, water quality verification and novel research laboratory instruments.

Lincoln College, Oxford, Uk

Tutoring undergraduate students in physics. I have taught: 1st year mathematical methods, 1st year mechanics, 2nd year mathematical methods, 2nd year quantum mechanics, 2nd year thermodynamics, 3rd year biophysics.

Department Of Physics, University Of Oxford

Research student in the field of biophysics/bionanotechnology. Particularly interested in novel technologies based on new understanding of biological organisms/components at the cellular and sub-cellular level.My thesis (defended January 2013) is titled: "Digital Holographic Microscopy for Three-Dimensional Studies of Microorganisms"​. It describes the development of a modular, multiple-magnification digital holographic microscope capable of operating in both off-axis and inline imaging modalities. Holograms can be acquired at up to 2,000 frames per second. The microscope was used for preliminary studies into the 3D swimming behaviour of populations of bacteriaResearch interests: bacterial motility, technological applications of bacteria, microhydrodynamics, optical trapping techniques, holography, micro-fluid dynamics, particle image velocimetry

Department Of Physics

Research physicist developing novel forms of digital holographic microscopy for three-dimensional studies of bacterial motility along with miniaturizing digital holographic microscopes for commercial applications.

Oxford, England, United Kingdom

Professional counter-tenor lay clerk for Christ Church, Oxford.

Christchurch, Nz

Employed part time as a research physicist involved in the R&D of the company's latest biodetection technology.I developed fundamental physics research behind optical detection of diabetes and assisted in bringing this technology to the clinical prototype stage.

Tutor for 2nd year mathematics courses. Taught linear algebra, vector spaces, differential equations, vector calculus.

Specialised in teaching university-level mathematics to blind and visually-impaired students.Helped to pioneer a graphical tactile system for blind students of science, transcribing visual figures, graphs, diagrams etc into a braille-compatible tactile format.

Part time photographer, mostly weddings but some commercial work also.Digital processing, enhancement and restoration of damaged photographs.

D. Phil., Biophysics

Activities and Societies: Lincoln College MCR Social Secretary, Christ Church Cathedral Choir, Oxford Savate (French Kickboxing), Oxford.

M.Sc., Physics

Activities and Societies: Seido Karate, ChristChurch Cathedral Choir (NZ)Graduated with Distinction. University of Canterbury Master's.

B.A., English, Mathematics

Activities and Societies: Seido Karate, ChristChurch Cathedral Choir (NZ)

B.Sc.(Hons), Physics

Activities and Societies: Seido Karate, ChristChurch Cathedral Choir (NZ)Graduated with First Class Honours University of Canterbury.