James Flewellen Email and Phone Number
James Flewellen work email
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Highly experienced multi-disciplinary scientist working at the interface of physics and biology. I am currently exploring applications of novel whole-cell biosensors developed at the University of Edinburgh. These sensors give real-time, near-instantaneous detection of minute quantities of chemicals and biomarkers. They deliver the data in an electronic format, integrating with other circuitry. I'm currently exploring applications in the water industry, food and drink, point-of-care diagnostics, drug discovery, autonomous marine vehicles and environmental monitoring. If you think this technology could be applied in your industry, please get in touch. Recently, I completed a five-year period at The Francis Crick Institute, London. I worked as a single-molecule biophysicist in a B-cell immunology group led by Prof. Pavel Tolar. I developed a novel technique for single-molecule force spectroscopy by integrating magnetic tweezers with digital holographic microscopy for 3D imaging. The research focused on the force-mediated immune response to HIV; however the techniques I developed could be applied to any antigen-antibody, or protein-protein, interaction.This role was a return to academia following a personal interest in applying novel physics and technology to cutting-edge issues in biomedical research.Prior to this role I co-founded and managed Speckle Technologies Ltd, a biotechnology start-up developing mobile diagnostics devices using digital holographic technology. My previous PhD and postdoctoral research at the University of Oxford was the development of 3D microscopy techniques to study the motile behaviour of microorganisms. I have a strong interest in science education and communication, with many years experience teaching and tutoring. I am also a wine communicator, educator and consultant. I run wine tastings in the UK and further afield. I co-wrote 'The Concise Guide to Wine and Blind Tasting', published in 2014, which was awarded a Gourmand Award for Best Drinks Education book. In 2020 I launched my innovative, infographic wine guides.Specialties: biotechnology, biophysics, optical microscopy, innovation, interdisciplinary science, single molecule techniques, holography, science communication, science education, tutoring, wine tasting, wine education.
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Research Associate – Biosensor Commercialisation LeadThe University Of EdinburghLondon, Gb
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Research Associate – Biosensor Commercialisation LeadThe University Of Edinburgh Nov 2021 - PresentDeveloping a spinout company based around a novel biosensor technology.We have developed a novel bioelectronic interface technology that leverages the exquisite sensing capabilities of microorganisms to detect trace chemicals in liquid environments, and couples this to a custom integrated circuit to produce an electronic output. My role is partly technical: bringing to life a prototype device by overseeing integration of microbiology, electronics, liquid handling and surface chemistry, as well as leading on device design and some specific bioengineering aspects. And partly business development: identifying product-market fit, beachhead markets, angel customers; securing funding for technology and business development; and building a team around me to form a company to take this university innovation into the world.I have raised >£330k in grant funding for commercialisation activities so far, through Innovate UK ICURe Programmes, Scottish Enterprise, IBioIC and Edinburgh Venture Builder Incubator.
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DirectorJames Flewellen Wine Aug 2011 - PresentLondon, United KingdomCreator of a new way to learn about wine via my innovative visual wine guides. This is a unique project combining high quality data on wine regions with a beautiful designed aesthetic. "Everything you need to know about a wine region on a single piece of paper." They are perfect for wine students and wine lovers seeking to further understand their wine knowledge.I am also an award-winning author (for the original edition of "The Concise Guide to Wine and Blind Tasting" which won the Gourmand Award for Best Drinks Education Book (UK)) and have over 10 years experience teaching and communicating about wine.My introduction to wine came through competitive blind tasting, and I competed in – and won – numerous university wine tasting competitions – both domestically in the UK and internationally. I hold the WSET Level 4 Diploma in Wine and Spirits and am a judge for the International Wine Challenge based in London.I also run wine tastings in the UK and further afield and You can find out more at www.jamesflewellen.com. -
Postdoctoral Research ScientistUcl Jul 2020 - Sep 2021London, England, United KingdomDuring this role, I developed a novel microscopy system for single-molecule force spectroscopy. This was achieved through integrating magnetic tweezers with digital holographic microscopy for 3D imaging of microscopic objects. I designed the experimental apparatus, wrote a 3D holographic image analysis software suite, and conducted force spectroscopy experiments of a range of protein-protein interactions.The aim of the project was to explore the biomechanics of B lymphocyte interaction with HIV envelope proteins under applied load, which better represents the physiological situation. However, the techniques I developed are applicable to a wide range of antibody-antigen and other protein-protein interactions.I worked at the interface of biophysics and immunology in this role in the laboratory of Pavel Tolar. The laboratory was based in the Francis Crick Institute, although I was initially employed by Imperial College London, until the adminstration of the funding grant was transferred to University College London in 2020. -
Postdoctoral Research ScientistThe Francis Crick Institute Jun 2016 - Sep 2021London, United KingdomI worked at the interface of biophysics and immunology in this role in the laboratory of Pavel Tolar.My laboratory was based at the Francis Crick Institute; however I was employed first by Imperial College London and then University College London when the administration of the funding grant was moved.During this role, I developed a novel microscopy system for single-molecule force spectroscopy. This was achieved through integrating magnetic tweezers with digital holographic microscopy for 3D imaging of microscopic objects. I designed the experimental apparatus, wrote a 3D holographic image analysis software suite, and conducted force spectroscopy experiments of a range of protein-protein interactions.The aim of the project was to explore the biomechanics of B lymphocyte interaction with HIV envelope proteins under applied load, which better represents the physiological situation. However, the techniques I developed are applicable to a wide range of antibody-antigen and other protein-protein interactions.I also co-founded and ran the Single-Molecule Network – a network of London-based multidisciplinary scientists working at the cutting edge of single-molecule research. I helped establish this network and set up a series of half-day conferences at the Crick Institute to bring together single-molecule researchers working on disparate problems in the biomedical space. -
Postdoctoral Research ScientistImperial College London Jun 2016 - Jun 2020London, United KingdomDuring this role, I developed a novel microscopy system for single-molecule force spectroscopy. This was achieved through integrating magnetic tweezers with digital holographic microscopy for 3D imaging of microscopic objects. I designed the experimental apparatus, wrote a 3D holographic image analysis software suite, and conducted force spectroscopy experiments of a range of protein-protein interactions.The aim of the project was to explore the biomechanics of B lymphocyte interaction with HIV envelope proteins under applied load, which better represents the physiological situation. However, the techniques I developed are applicable to a wide range of antibody-antigen and other protein-protein interactions.I worked at the interface of biophysics and immunology in this role in the laboratory of Pavel Tolar. The laboratory was based in the Francis Crick Institute, although I was employed by Imperial College London, until the adminstration of the funding grant was transferred to University College London in 2020. -
Co-Founder And CeoSpeckle Technologies Aug 2013 - Nov 2016Oxford, United KingdomEmerging from my academic research at Oxford University, Speckle Technologies was created to develop a mobile medical diagnostics platform. Speckle combines 3D imaging techniques with machine learning algorithms to produce optical diagnostics routines that are fast, efficient and cheaper than conventional laboratory-based techniques. Application areas include: medical diagnostics, veterinary science, food and beverage quality assurance, water quality verification and novel research laboratory instruments.
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LecturerLincoln College, University Of Oxford Sep 2011 - Jun 2016Lincoln College, Oxford, UkTutoring undergraduate students in physics. I have taught: 1st year mathematical methods, 1st year mechanics, 2nd year mathematical methods, 2nd year quantum mechanics, 2nd year thermodynamics, 3rd year biophysics. -
Doctoral Research StudentLincoln College, University Of Oxford Oct 2008 - Oct 2012Department Of Physics, University Of OxfordResearch student in the field of biophysics/bionanotechnology. Particularly interested in novel technologies based on new understanding of biological organisms/components at the cellular and sub-cellular level.My thesis (defended January 2013) is titled: "Digital Holographic Microscopy for Three-Dimensional Studies of Microorganisms". It describes the development of a modular, multiple-magnification digital holographic microscope capable of operating in both off-axis and inline imaging modalities. Holograms can be acquired at up to 2,000 frames per second. The microscope was used for preliminary studies into the 3D swimming behaviour of populations of bacteriaResearch interests: bacterial motility, technological applications of bacteria, microhydrodynamics, optical trapping techniques, holography, micro-fluid dynamics, particle image velocimetry -
Post-Doctoral Research ScientistUniversity Of Oxford Oct 2012 - Oct 2014Department Of PhysicsResearch physicist developing novel forms of digital holographic microscopy for three-dimensional studies of bacterial motility along with miniaturizing digital holographic microscopes for commercial applications.
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Alto Lay ClerkChrist Church, Oxford Jan 2009 - Sep 2009Oxford, England, United KingdomProfessional counter-tenor lay clerk for Christ Church, Oxford. -
Research PhysicistVeritide Ltd Oct 2007 - Oct 2008Christchurch, NzEmployed part time as a research physicist involved in the R&D of the company's latest biodetection technology.I developed fundamental physics research behind optical detection of diabetes and assisted in bringing this technology to the clinical prototype stage.
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Mathematics TutorUniversity Of Canterbury Feb 2006 - Jun 2008Tutor for 2nd year mathematics courses. Taught linear algebra, vector spaces, differential equations, vector calculus. -
Tutor And Tactile Transcriber For Disability SupportUniversity Of Canterbury Nov 2005 - Jun 2008Specialised in teaching university-level mathematics to blind and visually-impaired students.Helped to pioneer a graphical tactile system for blind students of science, transcribing visual figures, graphs, diagrams etc into a braille-compatible tactile format.
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Wedding PhotographerSydenham Photographics 2004 - 2008Part time photographer, mostly weddings but some commercial work also.Digital processing, enhancement and restoration of damaged photographs.
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Alto Choral ScholarChrist Church Cathedral Choir, Nz 2003 - 2008
James Flewellen Skills
James Flewellen Education Details
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Biophysics
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Physics
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English, Mathematics
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Physics
Frequently Asked Questions about James Flewellen
What company does James Flewellen work for?
James Flewellen works for The University Of Edinburgh
What is James Flewellen's role at the current company?
James Flewellen's current role is Research Associate – Biosensor Commercialisation Lead.
What is James Flewellen's email address?
James Flewellen's email address is yi****@****ail.com
What schools did James Flewellen attend?
James Flewellen attended University Of Oxford, University Of Canterbury, University Of Canterbury, University Of Canterbury.
What are some of James Flewellen's interests?
James Flewellen has interest in Literature, Photography, Wine Tasting, Science Communication And Education, Martial Arts, Singing, Philosophy.
What skills is James Flewellen known for?
James Flewellen has skills like Physics, Microscopy, Science, Research, Experimentation, Statistics, Latex, Mathematical Modeling, Data Analysis, Image Processing, Scientific Computing, Holography.
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