James Klimavicz Email & Phone Number

Cary, NC, US

Assess customer scientific use cases, data workflows, and data integration needs. Propose architectural diagrams for improved data workflows. Develop and update vendor-agnostic schema for harmonized data ingestion. Serve as scientific subject matter expert in chromatography. Work with customer data scientists to improve data querying from the TetraScience.

Morrisville, North Carolina, United States

Project leader for the development, synthesis, and assaying of biologically active small molecules with novel modes of action.High-throughput virtual screening of ligand-protein interactions of small molecules for lead compound identification and optimization, incorporating machine learning and clustering for classifying potential compound leadsDevelopment.

Ames, Iowa

PhD Student in Toxicology and ChemistryGraduate Minors in Entomology and StatisticsPreparation, purification, and characterization of more than 400 heterocyclic small molecules and synthetic terpenoid analogs for screening for pesticidal activity. Development of (quantitative) structure-activity relationship models and analysis of dose-response.

Cambridge, United Kingdom

MPhil in Scientific Computing, Darwin CollegeExploration of stable conformers and molecular dynamics evaluation of small DNA sequences implicated in genetic diseases and microbiological pathogenesis. Development, implementation, and integration of high-performance computing algorithms written in Fortran 90 into computational chemistry packages for.

Ames, Iowa

• Preparation and characterization of synthetic terpenoids for screening for insecticidal activity and insect repellency. Projects include:
• Fluorination and functional group transformations of sequiterpenoids
• Development of terpenoid-based additives for insect-control baits
• Isolation and purification of natural terpenoids from crude extracts and natural oils

Bethesda, MD

• Development and optimization of antibody assays to detect disease using human sera. Projects included:
• Searching for novel antibodies in sera for specific diseases, such as tuberculosis and Sjögren’s Syndrome, an autoimmune disease
• Synthesis of antibody-luciferase chimera proteins via plasmid ligation for light-based immunoprecipitation studies
• Development of high-throughput sera assays to detect potential for disease formation prior to clinically significant symptoms
• Statistical analysis of RNA-Seq data to discover trends using mathematic modeling

Ames, Iowa

Ames, Iowa

• Preparation and characterization of pi-conjugated monomers for various uses, including organic light emitting diodes, organic field effect transistors, photovoltaics, and fluorescence microscopy. Projects included:
• Synthesis of symmetric and asymmetric 2,6-disubstituted benzobisazoles for potential use in organic electronic devices
• Development of an innovative method for making orthoesters for synthetic chemistry and biochemical applications

Doctor Of Philosophy - Phd, Organic Chemistry And Toxicology

Activities and Societies: Vice President of the Graduate and Professional Student Senate (2019-2020), Graduate and Professional Student.

Master Of Philosophy - Mphil, Scientific Computing

Bachelor’S Degree, Mathematics, Gpa: 3.79

Activities and Societies: Phi Beta Kappa, Pi Mu Epsilon Minors in Computer Science and History

Master'S Degree, Organic Chemistry, Gpa: 3.88

Activities and Societies: Younger Chemists Committee

Bachelor'S Degree, Chemistry, Gpa: 3.55