Project: Fully Synthetic Trioxacarcin-Antibody Drug Conjugates for Targeted Cancer Therapy• Worked to develop a functional trioxacarcin-antibody drug conjugate comprised of a fully synthetic trioxacarcin and a suitable cleavable linker• Developed chemistry within the current modular route to access new C16 substituted trioxacarcins

Advisor: Dr. Andrew J. Gaunt• Prepared aqueous and non-aqueous neptunium precursors• Studied redox chemistry of Np(VI) and Np coordination chemistry with expanded porphyrin ligands (ligands prepared in 8-21 steps)Awarded twice: Summer 2018 & Spring 2019

Advisor: Professor Jonathan SesslerThesis Title: Hexaphyrin-based Systems in f-Element Coordination Chemistry • Carried out the first reported metallation studies of dipyriamethyrin (9 steps) with uranyl & neptunyl; thorium, uranium, & neptunium; and copper - publications in JACS, Chemical Communications, and Molecules• Conceived and initiated a research program using metallotexaphyrins as a new class of theranostics for Alzheimer’s and other CNS neurodegenerative diseases-published in Chem• Synthesized pyrihexaphyrin (18 steps) and elucidated a putative mechanism for the ring contraction observed after reaction with uranyl(VI) silylamide and purification with basic aluminum oxide- published in Chemical Science• Worked on projects in supramolecular and inorganic chemistry with a focus on synthetic chemistry resulting in over 15 additional publications

Advisors: Professor Luigi Casella & Dr. Simone Dell’Acqua• Awarded a fellowship to work with Professor Casella to elucidate the antioxidant properties of metallotexaphyrins towards deactivating ROS and RNS in the context of CNS neurodegeneration- two papers published in Molecules and Chem

Advisors: Professors Hegui Gong and Zhan Zhang• Awarded a fellowship to develop new calix-based molecular machines• Carried out preliminary experiments on photoredox/ Ni-dual catalyzed arylation of alpha-bromo sugars

Advisor: Professor Kelvin GeeHonors Thesis Title: a9a10 nAChR Antagonists for Chronic Pain• Carried out SAR studies on alpha9alpha10 nAChR to develop therapeutics for neuropathic pain• Assisted with developing a regioselective, metal-free route for the synthesis of 2,3,5-trisubstituted pyridines. These compounds displayed utility as alpha7 nAChR Positive Allosteric Modulators