Jamie Planck Email & Phone Number

Spring House, Pennsylvania, United States

Spring House, Pennsylvania

Spring House, PA

BPO KellyOCG Compound Profiling, Screening Group, Lead Discovery

Malvern, PA

I used proprietary methods to test customer compounds in a high throughput manner against a large panel of kinases, methyltransferases, and smaller enzyme classes. I managed the customer accounts from the initial quote to the actual assays, all the way to the final report delivered to the customer.

I was responsible for generating large quantities of the hPARP1 protein, important in DNA repair, transcription and various cancers, for crystallographic studies. This included cloning and generating mutations in the full-length and subdomains of the protein, growing up large cultures of E. coli for protein expression, and purifying these proteins to a.

I investigated the molecular mechanism of the PTS, a conserved regulatory element within the Drosophila Bithorax Complex (BX-C), which exhibits anti-insulator and promoter targeting at the HOX gene Abdominal-B. Hox genes are conserved from Drosophila to humans and proper expression in both time and place are necessary for correct development of the body.

I produced and maintained Drosophila lines in a large-scale effort to GFP (green fluorescent protein) tag all Drosophila proteins allowing visualization of proteins in multiple tissues. I also screened lines using confocal microscopy to identify nucleolar proteins in the ovaries and salivary glands for further study.

Ms, Cellular And Molecular Biology

Ba, Biology