Jan Kroon Email and Phone Number

Coordinator of preclinical research team (based on academic-industry partnership) of 2 PhD-students, 2 postdocs and 2 research technicians. PhD-supervisor (‘co-promotor’) of 5 PhD-candidates (2 finished, 3 ongoing)Opposition committee member PhD-defensesRecipient LUMC Academic Pharma Research Theme grant

Main author on research articles on a new screening pipeline for novel glucocorticoid receptor-targeting drugs, preclinical characterization of clinical candidate relacorilant, endocrine mechanism of dexamethasone side effects and sexual dimorphism of glucocorticoid effects due to androgen status.doi: 10.1016/j.phrs.2021.105588 doi: 10.1530/JOE-22-0263 doi: 10.3389/fendo.2022.960279 doi: 10.1096.fj.202101313R doi: 10.3389/fendo.2022.907908Main applicant on subsidized research… Show more Main author on research articles on a new screening pipeline for novel glucocorticoid receptor-targeting drugs, preclinical characterization of clinical candidate relacorilant, endocrine mechanism of dexamethasone side effects and sexual dimorphism of glucocorticoid effects due to androgen status.doi: 10.1016/j.phrs.2021.105588 doi: 10.1530/JOE-22-0263 doi: 10.3389/fendo.2022.960279 doi: 10.1096.fj.202101313R doi: 10.3389/fendo.2022.907908Main applicant on subsidized research grants including IBSA Foundation Fellowship for Endocrinology 2020, LUF-Mulder-Hamelers, LUF-Elisa Mathilde. Co-applicant Leuven-Leiden Global PhD-fellowship.Active involvement in preclinical drug development of 3 lead compounds currently in clinical development for NASH, Cushing’s syndrome and ALS (Miricorilant, Relacorilant, Dazucorilant)Establishment of compound screening assays for new glucocorticoid receptor ligands to identify promising leadsEarly-career reviewer board member at Endocrinology and guest-editor at Frontiers of Endocrinology.Conference organizer of Nuclear Receptor Research Network meeting Leiden 2021. Show less

Main author on research articles on circadian glucocorticoid rhythm and metabolic health, crosstalk between the glucocorticoid and androgen receptor nuclear receptors in metabolic tissues, benefits of GR antagonists treatment for metabolic health. doi: 10.1210/en.2017-00512 doi: 10.1530/JOE-18-0503 doi: 10.1530/JOE-19-0486Award for best paper Journal of Endocrinology (2020) - https://www.endocrinology.org/grants-and-awards/prizes-and-awards/journal-awards/Eurolife grant… Show more Main author on research articles on circadian glucocorticoid rhythm and metabolic health, crosstalk between the glucocorticoid and androgen receptor nuclear receptors in metabolic tissues, benefits of GR antagonists treatment for metabolic health. doi: 10.1210/en.2017-00512 doi: 10.1530/JOE-18-0503 doi: 10.1530/JOE-19-0486Award for best paper Journal of Endocrinology (2020) - https://www.endocrinology.org/grants-and-awards/prizes-and-awards/journal-awards/Eurolife grant (2017) for research exchange to the University of Edinburgh Dept. Endocrinology to optimize LC-MS for detection of steroid hormones. Show less

Secondment to Corcept Therapeutics as consultant/senior researcher preclinical drug development.

Preclinical development of novel therapeutics for advanced prostate cancer. Special focus on targeted drug delivery of dexamethasone (in collaboration with Enceladus Pharmaceuticals), and the involvement of the glucocorticoid receptor in chemotherapy resistance. PhD degree obtained at the University of Twente.

Establishing the anti-apoptotic properties of IkappaBalpha in cancer. Enhancing sensitivity to apoptosis-induction by inferference with IkappaBalpha.

Examine the effect of the tumor-secreted factors on anti-tumor immunity

Establishing the effects of TGF-beta isoforms on cancer cell lines