Jan Mol is principal investigator in the field of endocrinology, oncology and functional genomics of companion animals. He is project leader of the program on Comparative and Translational Oncology which is part of the Regenerative Medicine program of Utrecht Life Sciences.He is responsible for the scientific and laboratory part of the oncology program. The projects are focussed around the role of cancer stem cells in mammary gland, adrenal gland, and in insulinomas. The laboratory has ample expertise in gene expression studies (microarray, qRT-PCR), cell culture (transfection, organoid culture), FACS analysis and protein chemistry (IHC, Wblot).His special interest is the role of progesterone in the pathogenesis of mammary cancer and in mammary cancer stem cell differentiation. Hallmarks are the discovery of the local mammary expression of growth hormone (GH) and IGF-I, expression analysis of mammary genes using microarray analysis, the unique role of the canine progesterone receptor-B and the Wnt signalling in mammary carcinogenesis.The current research program focuses on the role of the growth hormone receptor (GHR) in mammary carcinomas and new treatment modalities of adrenocortical tumors en chemoresistence in lymphomas.