Janet Carr Email and Phone Number
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I am passionate about problem solving, and I truly enjoy the satisfaction of helping others find simple solutions to their complex problems.Since 2004, I have been developing, automating, maintaining, and executing processes for CLIA-approved sequencing and genotyping tests. My recent focus has been on the analysis and interpretation of NGS data, and the integration of these processes with software tools, both internally-developed and third party, and previous experiences include laboratory process development and improvement. My responsibilities at Sema4 centered on the transmission and translation of NGS pipeline outputs into finalized clinical reports. I performed primary analysis, variant curation, and the QC and assembly of clinical reports. I manually shepherded the small percentage of edge cases which did not fit the original requirements of the systems and worked with the software teams to change the systems to include as many of the edge cases as possible.My early responsibilities at Genaissance (which eventually became Transgenomic through acquisitions) were in laboratory process creation and improvement. It was here that I gained expertise in the regulated environment of clinical genetics, from software and method validations to highly-effective and informative SOPs. I worked closely with the software team to create tools to support all aspects of the process, from accessioning through billing. Experience gained during my tenure here allowed me to obtain my New York State Department of Health Certificate of Qualification to act as a laboratory director.Experience has taught me how to build strong relationships with all departments at an organization. I have worked within fairly small teams with a narrow focus, containing individuals of very similar backgrounds. I have also helped my organization by facilitating clear communications between disparate teams with various areas of expertise.
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Senior Variant InterpreterSonic Healthcare Usa Apr 2023 - PresentAustin, Texas, UsInterpretation of genetic variants for ThyroSeq test -
Director Of Test DevelopmentSema4 2021 - Jan 2023Stamford, Connecticut, Us• Worked with software developers and bioinformatics to develop, test, validate, launch and improve data management systems, including custom in-house software solutions• Ensured data integrity by vigorously testing software and updates; identified edge cases to use in testing• Assessed clinical relevance of genes to determine which may require special laboratory techniques or specialized variant interpretation rules• Reviewed outcome of test runs in terms of coverage, failed regions, run metrics, and provide feedback to the wet lab• Continued to perform the responsibilities listed under previous titles -
Assistant DirectorSema4 2019 - 2021Stamford, Connecticut, Us• Led team of data analysts responsible for ensuring products of the NGS pipeline are reviewed and delivered to the clinical reporting team• Communicated needs of the clinical team to multiple software development teams, providing guidance on workflows from accessioning through reporting• Manually processed post-pipeline NGS data for newly-launched clinical tests and managed transitions to software solutions• Provided a bridge between clinical subspecialties, ensuring sharing of processes to minimize effort and maximize output -
Variant Curator IiSema4 2018 - 2019Stamford, Connecticut, Us• Reviewed clinical significance of variants detected in genetic testing• Gathered requirements for software tools to assist in automation of variant curation -
Variant CuratorSema4 2017 - 2018Stamford, Connecticut, Us• Reviewed clinical significance of variants detected in genetic testing -
Variant CuratorIcahn School Of Medicine At Mount Sinai 2016 - 2017New York, Ny, UsSee Sema4 experience: Our facility was spun out from the Icahn School of Medicine to Sema4 -
Senior Applications Scientist And Clep Laboratory DirectorTransgenomic 2011 - 2016Omana (Ne), Nebraska, Us• Led process improvement and QC activities for the laboratory. • Developed new clinical tests and expanded existing tests to include additional genes, including Sanger and NextGen sequencing, TaqMan genotyping, and MLPA.• Executed, analyzed and documented method validations for CLIA-approved clinical tests.• Interpreted clinical significance of variants for patient tests. • Managed throughput of clinical samples, ensuring consistent quality and timeliness. • Provided LIMS technical support to end users, including troubleshooting and database updates.• Elicited requirements from laboratory users and provided SQL and wireframes to internal and overseas developers to create new LIMS and other software applications.• Had primary responsibility for data structure and data migration of the variant database for variants discovered through clinical genetic testing.• Designed data model for database to manage test pricing and CPT coding information. -
Senior Research Scientist, Technology DevelopmentTransgenomic 2010 - 2011Omana (Ne), Nebraska, Us• Expanded the FAMILION® product line from LQTS and BrS testing to also include testing for CPVT and HCM. • Designed and created database/workflow tools for smaller applications using Microsoft Access.• Executed, analyzed and documented software and method validations for new clinical tests.• Managed throughput of clinical samples, ensuring consistent quality and timeliness. • Chaired the Clinical Change Control Board: Responsible for coordinating changes among the clinical services, software development, information technology, laboratory, and quality assurance groups. -
Senior Research Scientist, Technology DevelopmentPgxhealth 2010 - 2010(Please refer to same position with Transgenomic, Inc.) -
Associate Laboratory DirectorPgxhealth 2008 - 2010• Developed and improved processes for clinical testing, including both the wet laboratory and analysis and clinical reporting processes.• Collected requirements for the software development team on laboratory and analysis systems for the second generation of LIMS (third-party vendor), which was deployed to integrate new FAMILION Sanger sequencing tests.• Introduced third-party data analysis software and integrated it with the first generation LIMS for a transitional solution while awaiting the completion of the second-generation LIMS.• Designed and created database/workflow tools for smaller applications using Microsoft Access. -
Associate Director, Study Management; Senior Scientist; Process Manager, Familion®Cogenics, Inc. 2004 - 2007Us• Led analysis of sequencing data for the FAMILION® LQTS and BrS tests.• Worked closely with software engineers and laboratory personnel to identify key workflow and throughput issues and to develop cost effective solutions.• Managed personnel and bioinformatic processes as company transitioned from one internal R&D project to clinical testing and multiple client-focused projects.• Managed throughput of clinical samples, ensuring consistent quality and timeliness.• Coordinated processing and delivery of over 100 projects to clients, with excellent on-time performance even as project timelines became tighter. • Provided laboratory with Excel tools for software tracking when software development resources were unavailable and/or when timelines prevented a full cycle of software development and validation. -
Editorial AssistantJournal Of Experimental Zoology 1996 - 2006Routed manuscripts to the appropriate division editors and evaluated suitability of manuscript revisions.
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Group Leader, Gene FinishingGenaissance Pharmaceuticals 2002 - 2004Us• Coordinated processing and delivery of over 100 projects to clients, with excellent on-time performance even as project timelines became tighter. • Ensured quality and completeness of SNP and haplotype data for a database of >6000 genes which were sequenced in house.• Provided guidance to software development team on analysis tools for the first generation of clinical testing LIMS, which was deployed at launch of the FAMILION™ LQTS/BrS tests.• Managed personnel and bioinformatic processes during a time of transition from one internal R&D project to multiple client-focused projects.• Worked closely with software engineers and laboratory personnel to identify key workflow and throughput issues and to develop cost effective solutions. -
Project Leader, Process DevelopmentGenaissance Pharmaceuticals 2000 - 2001Us• Played a critical role in troubleshooting and improving the sequencing process as the sequencing throughput expanded five-fold within nine months.• Developed protocols for reducing costs and increasing throughput in the company’s high-throughput sequencing facility.• Received August 2000 Employee of the Month recognition for “Outstanding performance in improving efficiency and reducing the cost of operating the HAP™ Database.”• Designed and implemented custom robotic systems for sample preparation: The system was put into service in January 2001 and generated a ten-fold increase in productivity, while also increasing the quality of sequencing reads.• Managed expansion of laboratory facilities; Responsible for hiring subsequent laboratory manager. -
Research ScientistGenaissance Pharmaceuticals 1998 - 1999Us• Developed, improved, and maintained protocols for yeast transformation, colony screening, and genomic DNA purification.• Streamlined protocols on Genetix QPIX, Tecan Genesis, Robbins Hydra, and TomTec Quadra robotic workstations. -
Research TechnicianPerelman School Of Medicine At The University Of Pennsylvania 1988 - 1990Pa, UsWorked in an immunology laboratory studying lymphocyte activation. Became proficient in cell culture and the analysis of cellular markers using both ELISA (Enzyme-Linked ImmunoSorbent Assay) and FACS (Fluorescence-Activated Cell Sorting).
Janet Carr Skills
Janet Carr Education Details
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Yale UniversityMolecular Biology -
Cornell UniversityBiology
Frequently Asked Questions about Janet Carr
What company does Janet Carr work for?
Janet Carr works for Sonic Healthcare Usa
What is Janet Carr's role at the current company?
Janet Carr's current role is Clinical Geneticist | Systems Integrator | Liaison.
What is Janet Carr's email address?
Janet Carr's email address is ja****@****ma4.com
What schools did Janet Carr attend?
Janet Carr attended Yale University, Cornell University.
What skills is Janet Carr known for?
Janet Carr has skills like Sequencing, Genomics, Genetics, Molecular Biology, Biotechnology, Dna, Genotyping, Laboratory, Life Sciences, Dna Sequencing, Biomarkers, Bioinformatics.
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