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Janice Chen is the co-founder and CTO of Mammoth Biosciences, a biotechnology company based in the San Francisco Bay Area that is harnessing the diversity of nature to power the next generation of CRISPR products to detect and cure disease. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Janice received her PhD from the lab of Nobel Laureate Jennifer Doudna at University of California, Berkeley, where she investigated mechanisms of CRISPR-Cas proteins and is an inventor of several CRISPR-based technologies. Janice was selected as a Forbes 30 Under 30 in Healthcare, Business Insider's 30 Under 40 in Healthcare, Endpoints Top 20 Women in Biopharma, MIT Technology Review 35 Innovators Under 35, EY Entrepreneur Of The Year, SF Business Times Most Influential Women, and delivered a TEDx talk on the potential for CRISPR to democratize diagnostics.
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Co-Founder & CtoMammoth Biosciences Jul 2018 - PresentBrisbane, California, UsMammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life.
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Graduate Student ResearcherUniversity Of California, Berkeley Aug 2014 - Jun 2018Berkeley, Ca, UsI studied how DNA-cutting CRISPR proteins recognize and cut their target to enable more precise gene-editing tools and design proteins with novel functions. We described a conformational checkpoint that governs activation of Cas9 and identified a protein domain responsible for target sensing that was engineered to create a hyper-accurate Cas9 protein (HypaCas9). We also found that the Cas12 family of DNA-targeting CRISPR proteins have ideal properties for nucleic acid detection, which we developed into a programmable DNA detection technology called DETECTR. DETECTR accurately identified high risk HPV types in patient samples and functions as a platform for rapid and affordable diagnostics. -
Graduate Student InstructorUniversity Of California, Berkeley Aug 2015 - May 2017Berkeley, Ca, UsBiochemistry and Molecular Biology
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Research TechnicianHarvard Medical School Jul 2013 - Jul 2014Boston, Ma, UsTo investigate renewable energy solutions, we engineered a "Bionic Leaf" that integrates a light-driven, water-splitting catalyst ("Artificial Leaf") with the hydrogen-metabolizing bacterium Ralstonia eutropha H16. We identified viable conditions for R. eutropha that mitigate production of reactive oxygen species by the inorganic catalysts. We also engineered R. eutropha to produce medium-chain fatty acids by expressing a thioesterase, and improved yields by identifying and knocking out metabolic sinks for fatty acids. -
Undergraduate ResearcherJohns Hopkins Bloomberg School Of Public Health May 2011 - May 2013Baltimore, Md, UsThe Culotta lab is interested in the role of metal ions and oxygen radicals in biology and disease. We found that nutrient depravation stress induced mitochondrial superoxide damage to iron-sulfur clusters in yeast central metabolism. This disruption resulted in a buildup of acetate that is exported to acidify the environment, which can improve yeast cell growth during glucose starvation. -
Research InternKwazulu-Natal Research Institute For Tb - Hiv (K-Rith) Jun 2012 - Aug 2012Understanding the molecular signals that trigger dormant or active tuberculosis (TB) disease is essential for drug discovery and public health efforts. Previous studies in the Steyn lab identified a putative sensor of oxidative stress, which may be responsible for the metabolic shutdown in dormant mycobacteria. We engineered a reporter system to evaluate conditions of oxidative stress in the TB analog, Mycobacterium smegmatis.
Janice Chen Skills
Janice Chen Education Details
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University Of California, BerkeleyBiophysics And Structural Biology -
The Johns Hopkins UniversityMolecular And Cellular Biology
Frequently Asked Questions about Janice Chen
What company does Janice Chen work for?
Janice Chen works for Mammoth Biosciences
What is Janice Chen's role at the current company?
Janice Chen's current role is Co-founder & CTO at Mammoth Biosciences.
What is Janice Chen's email address?
Janice Chen's email address is j.****@****bio.com
What is Janice Chen's direct phone number?
Janice Chen's direct phone number is (703)-434*****
What schools did Janice Chen attend?
Janice Chen attended University Of California, Berkeley, The Johns Hopkins University.
What skills is Janice Chen known for?
Janice Chen has skills like Biochemistry, Molecular Biology, Protein Purification, Fret, Protein Bio Conjugation, Column Chromatography, Protein Structure, Radiolabeling, Molecular Cloning, Western Blotting, Polymerase Chain Reaction, Mentoring.
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