Janice Smires, Ms., Lcgc. Email & Phone Number

GeneDx (formerly Sema4)

New Brunswick, New Jersey, United States

Clinical prenatal and preconception genetic counselor

Elmwood Park, NJ

• Lead the Primary Analysis team, present topics related to analysis workflows and scientific concepts during biweekly meetings, ensure that proper workflows are adhered to, and provide insight on difficult analysis.
• Coordinate with various departments to ensure smooth program operation, quality, and prompt results; work directly with the director of Molecular Genetics and departments including the wet labs, R&D, Review Analysts.
• Play a critical role in the launch of new tests, including validation (assay/test design and analysis pipeline), backend informatic check, coordination between departments, and analysis SOP establishment and.
• Analyze NGS data on Tablet/IGV and Sanger data on MutationSurveyor/Sequencher. Handle interpretation on complicated variants, including pseudogene interference, homopolymer tracks, allele drop-out, large deletion or.
• Use of public online tools and databases for variant interpretation and classification.
• Handle familial test requests, including interpreting proband results and selecting appropriate testing methods.

Elmwood Park, NJ

• Established a brand new Sanger sequencing lab from scratch.
• Tested a fully automated pipeline with integrated database intervention in lab procedures.
• Established lab SOPs and perform test validations. Conducted validation on over 700 primer pairs, intended for clinical diagnosis and variant discovery in hereditary cancers.
• Analyzed sequencing data on MutationSurveyor, Tablet, and Sequencher. Monitor data quality and troubleshoot on lab processes.
• Established a comprehensive tracking workflow for the Primary Analysis team to ensure test quality.
• Trained, supervised, and managed two technicians.

New York, NY

• Part of the vigorous clinical development team, which explores and tests on novel technologies for potential application in molecular diagnosis services, modifies and devises technical protocols for the method.
• Assist on the development and launch of the Illumina Custom Amplicon Cancer Panel Assay service, which received conditional State-approval in January 2013. The contribution includes the participation on full validation.
• Currently leading and advising on the technical aspect of the development of two Next-Generation-Sequencing-based services, RainDance Thunderstorm and NimbleGen Capture Technology respectively. The contribution.

New York, NY

• Performed next generation DNA sequencing on ABI SOLiD system and Illumina HiSeq/MiSeq system, including library preparation, bead preparation/cluster generation, instrumentation and data QC.
• Managed and handled a great volume of projects, coordinated with lab members to obtain utmost efficiency and prompt data delivery, trained and supervised junior technicians on various tasks, and maintained a complex.
• Participated in innovation of commercial protocols for cost-effective and time-efficient alternatives to fit high-throughput core need. Presented technical results in X-Gen Congress & Expo 2012.
• Familiar with a wide variety of microarray assays, including Illumina gene expression array, Agilent miRNA, CGH, and ChIP-on-chip promoter array, Affymetrix gene expression array, as well as preliminary data analysis.

New York, NY

• Researched F-box protein Slimb involvement in the regulation of pro-apoptotic factor in Drosophila. Successfully create constructs with site-specific mutation and obtain stable transgenic fly lines.
• Perform molecular biological and biochemical experiments, such as in vitro mutagenesis, subcloning, and immunohistochemistry, as well as manipulation of gene expression, dissection, embryonic microinjection using.

Taipei, Taiwan

• Researched PI3K-AKT signaling pathway responses and cell cycle of non-small-cell lung cancer cells upon drug treatment. Conducted biochemical experiments, flow cytometry, MTT assay, and maintained cell culture.
• Presented in a national conference, 21st Annual Conference of Biomedical Sciences, Taiwan, 2006. “Prevention of PI3K-Akt Survival Signaling Cancer Pathway during Ellipticine-Induced Apoptosis in Human Non-Small-Cell.

Masters, Genetic Counseling/Counselor

Masters Of Sciences, Applied Biotechnology

Activities and Societies: Teaching Assistant - Principals of Biology I Adjunct Lecturer - Genomes and Diversity

Bachelor Of Education (B.Ed.), Natural Sciences Education