Translational Science lead for multiple clinical stage assets

Project lead for high throughput in vivo immuno-oncology discovery effortsPharmacology & translational biology core team member for clinical-stage oncology targetProject lead for collaboration with UCB Pharma in fibrosis.

Project lead for a discovery collaboration with GSK Muscle Metabolism Discovery Performance Unit. Project lead for collaboration with UBC Pharma to discover novel targets for Fibrosis.

Project lead for collaboration with GSK Muscle Metabolism Discovery Performance Unit. Conceived and implemented an in vivo high throughput screening campaign to identify novel muscle medicine targets. Formulated and tested hypotheses to evaluate therapeutic potential of multiple hits.Led pharmacology efforts for severe asthma lead compound. Managed PK/PD efforts, and established multiple preclinical models in house for steroid resistant asthma to test efficacy of lead biologic in vivo.Developed and executed in vivo models of hair growth for lead biologicsEvaluated early stage oncology lead target. Performed PK/PD, bioavailability studies, and evaluated multiple preclinical models for target engagement and efficacy.Developed and implemented pre-clinical models for Age-related Macular Degeneration.

Investigated molecular mechanisms underlying idiopathic pulmonary arterial hypertension

Characterization of novel muscle proteins

Investigated the role of early aberrations in endothelial function in the development of primary pulmonary hypertension of the newborn.Investigated the role of endothelial function following hypothermic cardiopulmonary bypass and its role in post cardiopulmonary bypass pulmonary hypertension.Investigated the effects of inhaled nitric oxide on endogenous nitric oxide and ET-1 regulation in the pulmonary circulation.