Julie Shields Email & Phone Number

Boston, MA, US

Boston, Massachusetts, US

- Supported Phase I/II trial conduct for precision oncology therapeutics – including study start-up, conduct, and closeout- Contributed to the development of key study documents including protocol, operational plans, pharmacy manual, patient medication diaries, and CSR- Managed the ICF process including development of the study master ICFs and the review.

Boston, Massachusetts, US

Boston, Massachusetts, US

- Designed and executed mechanism-of-action studies, including analysis of gene expression, pathway expression, protein levels, and target activity levels, to validate and advance drug discovery programs- Conducted mammalian cell culture-mediated genetic perturbation studies using RNAi and/or CRISPR, as well as pharmacological perturbation studies to.

New York, New York, US

- Performed assay development, assay validation, and sample analysis for nonclinical and clinical ligand binding assays (PK and ADA) to support the large molecule biotherapeutic portfolio; ligand binding assays (LBAs) on MSD and Gyrolab- Functioned as a key member of the Core Automation Team; utilized automation (automated liquid handlers - Hamilton.

Ithaca, NY, US

- Developed and ran assays for the interrogation of cell-free DNA (cfDNA) to examine DNA methylation and hydroxymethylation as diagnostic biomarkers for organ transplant patients- Extracted cfDNA from urine and plasma samples and performed PCR and qPCR- Utilized immunocapture, on-bead PCR, and chemical labeling techniques- Performed literature searches on.

Tokyo, JP

- Used various molecular biology techniques to isolate subcellular compartments from HEK293 cell line in order to investigate the biodistribution and biotransformation of an antibody-drug conjugate- Optimized an electrochemiluminescence (ECL) assay to quantify antibody-drug conjugate (ADC) isolated from the subcellular compartments- Optimized immunocapture.

Lawrence Township, NJ, US

- Performed method development using novel, proprietary reagents and automation to improve drug tolerance in immunogenicity assays- Evaluated methods for drug tolerance, robustness, and ability to meet FDA requirements- Ran affinity chromatography experiments on Agilent's AssayMAP Bravo - Ran bead-based immunocapture experiments on Thermo Scientific's.

Lawrence Township, NJ, US

- Developed and optimized ligand binding assays to evaluate the immunogenicity of a protein biotherapeutic- Evaluated emerging technologies and assays for compliance with FDA regulatory requirements and for their ability to support clinical trials- Ran assays using Meso Scale Discovery Electrochemiluminescence, BioScale’s Acoustic Membrane Micro Particle.

- Obtained and processed information necessary to admit or register emergency room patients- Greeted and assisted patients in a timely and courteous manner- Handled urgent emergencies quickly without compromising patient health or safety- Practiced compliance with HIPPA to protect patient information and ensure each patient received equal and adequate.

Chicago, Illinois, US

- Refereed competitive league and cup soccer games- Enforced the rules of the game and ensured player safety at all times- Handled disputes between players, coaches, and spectators in a professional manner

Master Of Engineering (Meng), Biomedical Engineering

Bachelor Of Science (Bs), Biological Engineering

High School Diploma & International Baccalaureate Diploma