Jason Webber Email & Phone Number

'Exploring why some cancers are more aggressive than others'I am a Senior Lecturer within the Swansea University Medical School. I have a long standing interest in the role of extracellular vesicles (EVs) as modulators of the tumour microenvironment and as a source of disease biomarkers. I am the current Secretary for the UK Society of Extracellular Vesicles (UKEV).My research focuses on the role of small extracellular vesicles (EVs), often referred to as exosomes, as drivers of aggressive prostate cancer. We have previously demonstrated that cancer cell-derived exosomes can activate stromal cells, also present within the tumour microenvironment, thereby facilitating enhanced tumour growth. This function of EVs is likely due to heparan sulphate proteoglycans (HSPGs), present on the EV surface, which are required for EV-mediated growth factor delivery. In addition to their functional role, such EV-HSPGs may serve as novel biomarkers capable of discriminating patients with aggressive forms of cancer from those with slow growing tumours. We are exploring novel methodologies for combining multiple biomarkers, and have an interest in the use of AI-based approaches to achieve this.Additional research interests within my lab include isolation of EVs from biofluid, functional analysis of EVs, and the role of EVs in rare diseases (e.g. Tuberous Sclerosis Complex).

Listed skills include Nanosight, Oncology, Prostate Cancer, Exosomes, and 26 others.